Results 81 to 90 of about 127,292 (260)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Indirect sliding mode adaptive fractional order nonlinear observer based controller with fractional order single-ended primary inductor converter

International Journal of Electrical Power & Energy Systems
Direct Current to Direct Current (DC/DC) converters like the SEPIC (Single-Ended Primary-Inductor Converter) use both passive and active components to control the system via a duty cycle. The SEPIC converter is non-inverting and can both step up and step
Sena Alemu Wondimu, Desalegn Tsega Dagne, Kinde Anlay Fante   +2 more
doaj   +1 more source

Fractional Mass-Spring-Damper System Described by Generalized Fractional Order Derivatives

Fractal and Fractional, 2019
This paper proposes novel analytical solutions of the mass-spring-damper systems described by certain generalized fractional derivatives. The Liouville−Caputo left generalized fractional derivative and the left generalized fractional derivative ...
Ndolane Sene, José Francisco Gómez Aguilar   +1 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Fracmemristor: Fractional-Order Memristor

IEEE Access, 2016
This paper mainly discusses an interesting conceptual framework: the fractional-order memristor (fracmemristor). It is a challenging theoretical problem to determine what the fracmemristor interpolating characteristics between the memristor and the ...
Yi-Fei Pu, Xiao Yuan
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Correction: Impulsive fractional order integrodifferential equation via fractional operators

PLoS ONE
[This corrects the article DOI: 10.1371/journal.pone.0282665.].
PLOS ONE Staff
doaj   +3 more sources

Fractional-order Chelyshkov collocation method for solving variable-order fractional differential equations

Journal of Inequalities and Applications
This paper presents an efficient numerical method for solving variable-order fractional differential equations (VO-FDEs) by using the fractional-order Chelyshkov functions (FCHFs).
M. S. Al-Sharif, A. I. Ahmed, M. S. Salim   +2 more
doaj   +1 more source