Results 71 to 80 of about 97,065 (260)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

The Proposed Modified Liu System with Fractional Order

open access: yesAdvances in Mathematical Physics, 2013
The chaos in a new system with order 3 is studied. We have shown that this chaotic system again will be chaotic when the order of system is less than 3.
Alireza K. Golmankhaneh   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Dynamic Analysis of a Fractional-Order Economic Model: Chaos and Control

open access: yesFractal and Fractional
Fractional calculus in discrete-time is a recent field that has drawn much interest for dealing with multidisciplinary systems. A result of this tremendous potential, researchers have been using constant and variable-order fractional discrete calculus in
Ali Aloui   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

On Non-Commensurate Fractional-Order System Control

open access: yesMathematics
The control systems for models described by non-commensurate fractional-order differential equations are based on their transformation into large commensurate-order systems, which impose difficulties in determining control laws.
Mircea Ivanescu, Decebal Popescu
doaj   +1 more source

Numerical Analysis, Circuit Simulation, and Control Synchronization of Fractional-Order Unified Chaotic System

open access: yesMathematics, 2019
The traditional method of solving fractional chaotic system has the problem of low precision and is computationally cumbersome. In this paper, different fractional-order calculus solutions, the Adams prediction−correction method, the Adomian ...
Guohui Li, Xiangyu Zhang, Hong Yang
doaj   +1 more source

Control and Dynamics of Fractional Order Systems [PDF]

open access: yes, 2009
Fractional Calculus (FC) goes back to the beginning of the theory of differential calculus. Nevertheless, the application of FC just emerged in the last two decades due to the progress in the area of nonlinear dynamics. This article discusses several applications of fractional calculus in science and engineering, namely: the control of heat systems ...
Machado, J. A. Tenreiro   +3 more
openaire   +3 more sources

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