Results 51 to 60 of about 4,114 (261)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Conformable Laplace Transform of Fractional Differential Equations

open access: yesAxioms, 2018
In this paper, we use the conformable fractional derivative to discuss some fractional linear differential equations with constant coefficients.
Fernando S. Silva   +2 more
doaj   +1 more source

Fractional high order methods for the nonlinear fractional ordinary differential equation [PDF]

open access: yesNonlinear Analysis: Theory, Methods & Applications, 2007
The paper begins by referring to applications of fractional order equations, along with a brief summary of the main results achieved for this type of equation in the last decade. The authors consider the nonlinear fractional-order order differential equation (NFOODE), \(_0D_t^\alpha y(t)=f(y,t), (t>0), n ...
Lin, R, Liu, Fawang
openaire   +3 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

On the stabilization of a coupled fractional ordinary and partial differential equations†

open access: yesIranian Journal of Numerical Analysis and Optimization, 2020
We investigate the stabilization problem of a cascade of a fractional ordinary differential equation (FODE) and a fractional diffusion (FD) equation, where the interconnections are of Neumann type. We exploit the PDE back stepping method as a powerful tool for designing a controller to show the Mittag–Leffler stability of the FD-FODE cascade.
Amiri, Shadi, Keyanpour, Mohammad
openaire   +2 more sources

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

The closed-form solution by the exponential rational function method for the nonlinear variable-order fractional differential equations

open access: yesFrontiers in Physics
The symmetry features of fractional differential equations allow effective explanation of physical and biological phenomena in nature. The generalized form of the fractional differential equations is the variable-order fractional differential equations ...
Mashael M. ALBaidani   +2 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

About Some Possible Implementations of the Fractional Calculus

open access: yesMathematics, 2020
We present a partial panoramic view of possible contexts and applications of the fractional calculus. In this context, we show some different applications of fractional calculus to different models in ordinary differential equation (ODE) and partial ...
María Pilar Velasco   +5 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

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