Results 61 to 70 of about 5,172 (299)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Exact solutions for STO and (3+1)-dimensional KdV-ZK equations using G′G2-expansion method

Results in Physics, 2017
This article deals with finding some exact solutions of nonlinear fractional differential equations (NLFDEs) by applying a relatively new method known as G′G2-expansion method.
Sadaf Bibi, Syed Tauseef Mohyud-Din, Rahmat Ullah, Naveed Ahmed, Umar Khan   +4 more
doaj   +1 more source

Approximation of ordinary fractional differential equations by differential equations with a small parameter

Vestnik Udmurtskogo Universiteta. Matematika. Mekhanika. Komp'yuternye Nauki, 2017
Summary: An approach to approximate ordinary fractional differential equations by integer-order differential equations is proposed. It is assumed that the order of fractional differentiation is close to an integer. Perturbation expansions for the Riemann-Liouville and Caputo fractional derivatives are derived in terms of a suitable small parameter ...
openaire   +3 more sources

Further studies on ordinary differential equations involving the $ M $-fractional derivative

AIMS Mathematics, 2022
<abstract><p>In the current paper, the power series based on the $ M $-fractional derivative is formally introduced. More peciesely, the Taylor and Maclaurin expansions are generalized for fractional-order differentiable functions in accordance with the $ M $-fractional derivative.
A. Khoshkenar, Mousa Ilie, K. Hosseini, Dumitru Băleanu, Soheil Salahshour, C. Park, J. R. Lee   +6 more
openaire   +2 more sources

SOLVABILITY FOR A COUPLED SYSTEM OF 4-SEQUENTIAL FRACTIONAL DIFFERENTIAL EQUATIONS [PDF]

The present work deals with a coupled system of fractional differential equations involving four sequential Caputo derivatives in each of its components.
Dahmani, Zoubir, Sarikaya, Mehmet zeki, Bensassa, Kamel   +2 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Fractional high order methods for the nonlinear fractional ordinary differential equation [PDF]

Nonlinear Analysis: Theory, Methods & Applications, 2007
The paper begins by referring to applications of fractional order equations, along with a brief summary of the main results achieved for this type of equation in the last decade. The authors consider the nonlinear fractional-order order differential equation (NFOODE), \(_0D_t^\alpha y(t)=f(y,t), (t>0), n ...
Lin, R, Liu, Fawang
openaire   +3 more sources

On the stabilization of a coupled fractional ordinary and partial differential equations†

Iranian Journal of Numerical Analysis and Optimization, 2020
We investigate the stabilization problem of a cascade of a fractional ordinary differential equation (FODE) and a fractional diffusion (FD) equation, where the interconnections are of Neumann type. We exploit the PDE back stepping method as a powerful tool for designing a controller to show the Mittag–Leffler stability of the FD-FODE cascade.
Amiri, Shadi, Keyanpour, Mohammad
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source