Results 51 to 60 of about 8,378 (264)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Fractional CCP: A Fuzzy Goal Programming Approach
International Journal of Industrial Engineering and Production Research, 2014 It is the purpose of this article to introduce a linear approximation technique for solving a fractional chance constrained programming (CC) problem. For this purpose, a fuzzy goal programming model of the equivalent deterministic form of the fractional ...
Yahia Zare Mehrjerdi
doaj
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
A Novel Approach for Solving Quadratic Fractional Programming Problems
Croatian Operational Research Review, 2018 In this paper, quadratic fractional programming (QFP) problems involving a factorized or non-factorized objective function and subject to homogenous or non-homogenous constraints are considered.
Mustafa Sivri +2 more
doaj +1 more source
An Algorithm for Quadratically Constrained Multi-objective Quadratic Fractional Programming with Pentagonal Fuzzy Numbers [PDF]
Operations Research and Decisions, 2022 This study proposes a methodology to obtain an efficient solution for a programming model which is multi-objective quadratic fractional with pentagonal fuzzy numbers as coefficients in all the objective functions and constraints.
Vandana Goyal +2 more
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
FINANCIAL STRUCTURE OPTIMIZATION BY USING A GOAL PROGRAMMING APPROACH
Croatian Operational Research Review, 2012 This paper proposes a new methodology for solving the multiple objective fractional linear programming problems using Taylor’s formula and goal programming techniques.
Tunjo Perić, Zoran Babić
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
A Proposal to the Solution of Multiobjective Linear Fractional Programming Problem
Abstract and Applied Analysis, 2013 We have proposed a new solution to the Multiobjective Linear Fractional Programming Problem (MOLFPP). The proposed solution is based on a theorem that deals with nonlinear fractional programming with single objective function and studied in the work by ...
Nuran Güzel
doaj +1 more source