Results 51 to 60 of about 84,498 (293)
Journal of Inequalities and Applications, 2019 A new class of (not necessarily differentiable) multiobjective fractional programming problems with E-differentiable functions is considered. The so-called parametric E-Karush–Kuhn–Tucker necessary optimality conditions and, under E-convexity hypotheses,
Tadeusz Antczak, Najeeb Abdulaleem
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
The complexity of finite-valued CSPs
, 2016 We study the computational complexity of exact minimisation of rational-valued discrete functions. Let $\Gamma$ be a set of rational-valued functions on a fixed finite domain; such a set is called a finite-valued constraint language.
Thapper, Johan, Zivny, Stanislav
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Generalized Heptagonal Membership Function for Fully Fuzzy Linear Fractional Programming Problems
Ibn Al-Haitham Journal for Pure and Applied SciencesIdentifying the optimum solution that satisfies the restrictions and maximizes or minimizes the objective function is the aim of fully fuzzy fractional programming (FFFLP). Due to the inclusion of both fuzzy parameters and fractional variables, this
Israa Hadi, Iden H. Al Kanani
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Mechanism Design via Dantzig-Wolfe Decomposition [PDF]
, 2016 In random allocation rules, typically first an optimal fractional point is calculated via solving a linear program. The calculated point represents a fractional assignment of objects or more generally packages of objects to agents.
Fadaei, Salman
core
Logic Integer Programming Models for Signaling Networks
, 2008 We propose a static and a dynamic approach to model biological signaling networks, and show how each can be used to answer relevant biological questions. For this we use the two different mathematical tools of Propositional Logic and Integer Programming.
Haus U.-U. +5 more
core +3 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
An Algorithm for Quadratically Constrained Multi-objective Quadratic Fractional Programming with Pentagonal Fuzzy Numbers [PDF]
Operations Research and Decisions, 2022 This study proposes a methodology to obtain an efficient solution for a programming model which is multi-objective quadratic fractional with pentagonal fuzzy numbers as coefficients in all the objective functions and constraints.
Vandana Goyal +2 more
doaj