Results 71 to 80 of about 8,445 (264)

Efficiency and generalized concavity for multi-objective set-valued programming

Journal of Numerical Analysis and Approximation Theory, 2003
The purpose of this paper is to give sufficient conditions of generalized concavity type for a local (weakly) efficient solution to be a global (weakly) efficient solution for a vector maximization set-valued programming problem.
Ş. Ţigan, I.M. Stancu-Minasian
doaj   +2 more sources

Fuzzy linear fractional programming problem using the lexicography method

Vojnotehnički Glasnik
Introduction/purpose: In solving real-life fractional programming problems, uncertainty and hesitation are often encountered due to various uncontrollable factors.
Sivakumar Karthick, Appasamy Saraswathi, Seyyed Ahmad Edalatpanah   +2 more
doaj   +1 more source

Web-oriented software for solving linear programming problems by graphical method

CTE Workshop Proceedings, 2015
The aim of work is to create web-oriented software for solving mathematical programming problems by graphical methods. Object of research is graphical methods for solving some mathematical programming problems.
E. V. Zaloyko, Yu. V. Tryus
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Solving Linear Fractional Programming Problems in Uncertain Environments: A Novel Approach with Grey Parameters [PDF]

Control and Optimization in Applied Mathematics
Fractional programming is a significant nonlinear planning tool within operation research. It finds applications in diverse domains such as resource allocation, transportation, production programming, performance evaluation, and finance.
Farid Pourofoghi, Davood Darvishi Salokolaei   +1 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Branch and Bound Algorithm for a Discrete Multilevel Linear Fractional Programming Problem

Operations Research and Decisions, 2018
An algorithm is proposed to find an integer solution for bilevel linear fractional programming problem with discrete variables. The method develops a cut that removes the integer solutions which are not bilevel feasible.
Ritu Arora, Kavita Gupta
doaj  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source