Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
A linear fractional bilevel programming problem with multichoice parameters
Croatian Operational Research Review, 2017 A bilevel programming problem (BLPP) is a hierarchical optimization problem where the constraint region of the upper level is implicitly determined by the lower level optimization problem.
Ritu Arora, Kavita Gupta
doaj +1 more source
Genetic algorithmic based approach for multiple-objective probabilistic fractional programming problem involving discrete random variables. [PDF]
PLoS One, 2022 Belay B, Abebaw A.
europepmc +1 more source
Duality in Fractional Programming Involving Locally Arcwise Connected and Related Functions [PDF]
A nonlinear fractional programming problem is considered, where the functions involved are diferentiable with respect to an arc.Necessary and su±cient optimality conditions are obtained in terms of the right diferentials with respect to an arc of the ...
Emilio Cerdá +3 more
core
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Efficiency and generalized concavity for multi-objective set-valued programming
Journal of Numerical Analysis and Approximation Theory, 2003 The purpose of this paper is to give sufficient conditions of generalized concavity type for a local (weakly) efficient solution to be a global (weakly) efficient solution for a vector maximization set-valued programming problem.
Ş. Ţigan, I.M. Stancu-Minasian
doaj +2 more sources
Fuzzy linear fractional programming problem using the lexicography method
Vojnotehnički GlasnikIntroduction/purpose: In solving real-life fractional programming problems, uncertainty and hesitation are often encountered due to various uncontrollable factors.
Sivakumar Karthick +2 more
doaj +1 more source
Web-oriented software for solving linear programming problems by graphical method
CTE Workshop Proceedings, 2015 The aim of work is to create web-oriented software for solving mathematical programming problems by graphical methods. Object of research is graphical methods for solving some mathematical programming problems.
E. V. Zaloyko, Yu. V. Tryus
doaj +1 more source
Exploring deep phylogenies using protein structure : a dissertation submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry, Institute of Natural and Mathematical Sciences, Massey University, Auckland, New Zealand [PDF]
, 2018 Recent times have seen an exponential growth in protein sequence and structure data. The most popular way of characterising newly determined protein sequences is to compare them to well characterised sequences and predict the function of novel sequences ...
Malik, Ashar J
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source