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Methods to accelerate fracture healing – a narrative review from a clinical perspective
Frontiers in ImmunologyBone regeneration is a complex pathophysiological process determined by molecular, cellular, and biomechanical factors, including immune cells and growth factors.
Bergita Ganse, Bergita Ganse
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Is sonic Hedgehog involved in human fracture healing? --a prospective study on local and systemic concentrations of SHH. [PDF]
PLoS ONE, 2014 INTRODUCTION: Sonic Hedgehog (SHH) is a new signalling pathway in bone repair. Evidence exist that SHH pathway plays a significant role in vasculogenesis and limb development during embryogenesis.
Stefan Eipeldauer +7 more
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Frontiers in Immunology, 2021 Following severe trauma, fracture healing is impaired because of overwhelming systemic and local inflammation. Glucocorticoids (GCs), acting via the glucocorticoid receptor (GR), influence fracture healing by modulating the trauma-induced immune response.
Yasmine Hachemi +7 more
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The Role of the Immune Cells in Fracture Healing
Current Osteoporosis Reports, 2018 Purpose of reviewBone fracture healing is a complex physiological process relying on numerous cell types and signals. Inflammatory factors secreted by immune cells help to control recruitment, proliferation, differentiation, and activation of ...
G. Baht, Linda Vi, B. Alman
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Muscle atrophy in polytraumatized patients – a longitudinal observational pilot study
Frontiers in PhysiologyIn polytraumatized patients, muscle atrophy appears more pronounced than in immobilized healthy study participants. However, rates and trajectories of the acute muscle atrophy and associated parameters have not been reported.
Danjana Teves +6 more
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PLoS ONE, 2016 Biomechanical tests are widely used in animal studies on osteoporotic fracture healing. However, the biomechanical recovery process is still unknown, leading to difficulty in choosing time points for biomechanical tests and in correctly assessing ...
Lin Chen +6 more
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NPY and CGRP Inhibitor Influence on ERK Pathway and Macrophage Aggregation during Fracture Healing
Cellular Physiology and Biochemistry, 2017 Aim: The aims of this study are to investigate the effects of neurotransmitters NPY and CGRP on ERK signaling in fracture healing, and to identify the correlation between macrophage aggregation and fracture healing. Methods: Male Sprague-Dawley rats were
Peng Tang +7 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The Apolipoprotein (APOE) ε4 allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD); however, many ε4 carriers remain cognitively intact into old age. Leveraging plasma neuron‐derived extracellular vesicles (NDEVs), we sought to identify biomarkers of cognitive resilience and their interplay with APOE ...
Apostolos Manolopoulos +17 more
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Scientific ReportsFracture healing is usually monitored by clinical impressions and radiographs. Objective and easy methods for assessing fracture healing without radiation would be beneficial. The aim of this study was to analyse whether weight and plantar pressure while
Elke Warmerdam +3 more
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SensorsInstrumented insoles have created opportunities for patient monitoring via long-term recordings of ground reaction forces (GRFs). As the GRF curve is altered in patients after lower-extremity fracture, parameters defined on established curve landmarks ...
Christian Wolff +5 more
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