Results 41 to 50 of about 189,298 (331)

Is sonic Hedgehog involved in human fracture healing? --a prospective study on local and systemic concentrations of SHH. [PDF]

PLoS ONE, 2014
INTRODUCTION: Sonic Hedgehog (SHH) is a new signalling pathway in bone repair. Evidence exist that SHH pathway plays a significant role in vasculogenesis and limb development during embryogenesis.
Stefan Eipeldauer, Anita Thomas, Leonard Hoechtl-Lee, Mathias Kecht, Harald Binder, Julia Koettstorfer, Markus Gregori, Kambiz Sarahrudi   +7 more
doaj   +1 more source

Intact Glucocorticoid Receptor Dimerization Is Deleterious in Trauma-Induced Impaired Fracture Healing

Frontiers in Immunology, 2021
Following severe trauma, fracture healing is impaired because of overwhelming systemic and local inflammation. Glucocorticoids (GCs), acting via the glucocorticoid receptor (GR), influence fracture healing by modulating the trauma-induced immune response.
Yasmine Hachemi, Anna E. Rapp, Sooyeon Lee, Ann-Kristin Dorn, Benjamin T. Krüger, Kathrin Kaiser, Anita Ignatius, Jan Tuckermann   +7 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Longitudinal weight and plantar pressure distribution while standing after tibial or malleolar fractures in patients with or without fracture union

Scientific Reports
Fracture healing is usually monitored by clinical impressions and radiographs. Objective and easy methods for assessing fracture healing without radiation would be beneficial. The aim of this study was to analyse whether weight and plantar pressure while
Elke Warmerdam, Sonja Baumgartner, Tim Pohlemann, Bergita Ganse   +3 more
doaj   +1 more source

New Parameters Based on Ground Reaction Forces for Monitoring Rehabilitation Following Tibial Fractures and Assessment of Heavily Altered Gait

Sensors
Instrumented insoles have created opportunities for patient monitoring via long-term recordings of ground reaction forces (GRFs). As the GRF curve is altered in patients after lower-extremity fracture, parameters defined on established curve landmarks ...
Christian Wolff, Elke Warmerdam, Tim Dahmen, Tim Pohlemann, Philipp Slusallek, Bergita Ganse   +5 more
doaj   +1 more source

NPY and CGRP Inhibitor Influence on ERK Pathway and Macrophage Aggregation during Fracture Healing

Cellular Physiology and Biochemistry, 2017
Aim: The aims of this study are to investigate the effects of neurotransmitters NPY and CGRP on ERK signaling in fracture healing, and to identify the correlation between macrophage aggregation and fracture healing. Methods: Male Sprague-Dawley rats were
Peng Tang, Chunguang Duan, Zheng Wang, ChunMei Wang, Guolin Meng, Kaifeng Lin, Qian Yang, Zhi Yuan   +7 more
doaj   +1 more source

Modulation of fracture healing by the transient accumulation of senescent cells

eLife, 2021
Senescent cells have detrimental effects across tissues with aging but may have beneficial effects on tissue repair, specifically on skin wound healing. However, the potential role of senescent cells in fracture healing has not been defined.
Dominik Saul, David G Monroe, Jennifer L Rowsey, Robyn Laura Kosinsky, Stephanie J Vos, Madison L Doolittle, Joshua N Farr, Sundeep Khosla   +7 more
doaj   +1 more source

Characterization of a reproducible model of fracture healing in mice using an open femoral osteotomy [PDF]

, 2020
Purpose: The classic fracture model, described by Bonnarens and Einhorn in 1984, enlists a blunt guillotine to generate a closed fracture in a pre-stabilized rodent femur.
Akkus, O., Anderson, J.M., Collier, C.D., Din, E.S., Greenfield, E.M., Hausman, B.S., Zulqadar, S.H.   +6 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Long-term continuous instrumented insole-based gait analyses in daily life have advantages over longitudinal gait analyses in the lab to monitor healing of tibial fractures

Frontiers in Bioengineering and Biotechnology
Introduction: Monitoring changes in gait during rehabilitation allows early detection of complications. Laboratory-based gait analyses proved valuable for longitudinal monitoring of lower leg fracture healing.
Elke Warmerdam, Christian Wolff, Marcel Orth, Tim Pohlemann, Bergita Ganse, Bergita Ganse   +5 more
doaj   +1 more source