Results 41 to 50 of about 91,875 (296)

Development of an ischemic fracture healing model in mice

Acta Orthopaedica, 2022
Background and purpose: In fracture healing, ischemia caused by vascular injuries, chronic vascular diseases, and metabolic comorbidities is one of the major risk factors for delayed union and non-union formation.
Maximilian M Menger, Janine Stutz, Sabrina Ehnert, Andreas K Nussler, Mika F Rollmann, Steven C Herath, Benedikt J Braun, Tim Pohlemann, Michael D Menger, Tina Histing   +9 more
doaj   +1 more source

Osteoimmunology of Fracture Healing

Current Osteoporosis Reports
Abstract Purpose of Review The purpose of this review is to summarize what is known in the literature about the role inflammation plays during bone fracture healing. Bone fracture healing progresses through four distinct yet overlapping phases: formation of the hematoma, development of the cartilaginous callus ...
Molitoris, Kristin Happ, Huang, Mingjian, Baht, Gurpreet Singh   +2 more
openaire   +2 more sources

Single‐Cell RNA Seq in Sydenham Chorea Shows B Cell HLA‐DR/DQ Upregulation and Plasma Cell Proteasomal Activation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The pathogenesis of Sydenham chorea remains unclear. We report a 10‐year‐old girl presenting with subacute chorea and mild carditis following Streptococcal throat infection. Single‐cell RNA sequencing on 30,794 peripheral immune cells from the patient and two sex‐matched controls revealed nine immune cell clusters.
Velda X. Han, Brooke A. Keating, Brian S. Gloss, Xianzhong Lau, Ruwani Dissanayake, Hiroya Nishida, Jessica Hayes, Shrujna Patel, Shekeeb S. Mohammad, Russell C. Dale   +9 more
wiley   +1 more source

Multiple targets identified with genome wide profiling of small RNA and mRNA expression are linked to fracture healing in mice

Bone Reports, 2021
Long-bone fracture is a common injury and its healing process at the fracture site involves several overlapping phases, including inflammation, migration of mesenchymal progenitors into the fracture site, endochondral ossification, angiogenesis and ...
Matthieu Bourgery, Erika Ekholm, Katja Fagerlund, Ari Hiltunen, Tero Puolakkainen, Juha-Pekka Pursiheimo, Terhi Heino, Jorma Määttä, Jussi Heinonen, Emrah Yatkin, Tiina Laitala, Anna-Marja Säämänen   +11 more
doaj   +1 more source

Assessing a Mitochondrial Disease Treatment via a Novel Statistical Technique for Accelerometer Data

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Therapeutic development for mitochondrial diseases, rare genetic disorders with pathogenic defects of oxidative phosphorylation, is hindered by unsatisfactory outcome measures. To address this problem, we provide the first clinical application of a novel, bias‐adjusted outcome measure of acceleration across a range of subjects ...
Ian W. McKeague, Kristin Engelstad, Yue Ge, Amber Tucker, Shufang Li, Jasim Uddin, Ziwei Zhao, John L. P. Thompson, Michio Hirano   +8 more
wiley   +1 more source

THE EFFECT OF DENERVATION ON FRACTURE HEALING , AN EXPERIMENTAL STUDY ON RABBITS [PDF]

Basrah Journal of Surgery, 2014
THE EFFECT OF DENERVATION ON FRACTURE HEALING , AN EXPERIMENTAL STUDY ON RABBITS Thamer A Hamdan , Mubder A Mohammed Saeed & Abbas Salman Ismael Abstract Many studies suggested a relation between denervation and fracture healing either in positive or ...
THAMIR A. HAMDAN, Mubder A Mohammed Saeed, Abbas Salman ISMAEL   +2 more
doaj   +1 more source

Longitudinal Relationship Between Pain and Depression in People With Inflammatory Arthritis: A Narrative Review

Arthritis Care &Research, EarlyView.
As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox, Saeed Farooq, Helen Twohig, Ian C. Scott   +3 more
wiley   +1 more source

Lived and care experiences of chronic musculoskeletal shoulder pain in Australian adults: A qualitative study

Arthritis Care &Research, Accepted Article.
Objectives Australian evidence on lived and care experiences of chronic musculoskeletal shoulder pain (CMSP), irrespective of disorder classification or disease, is limited. However, such evidence is important for person‐centred care and informing local service pathways and care guidelines or standards.
Sonia Ranelli, Joanne E. Jordan, Ilana N. Ackerman, Alison Thorpe, Jennifer G. Persaud, Linda J. Woodhouse, Jason Chua, Ben Horgan, Andrew M. Briggs   +8 more
wiley   +1 more source

Chronic Opioids in Gout: A Matched Cohort Study from the Veteran's Health Administration

Arthritis Care &Research, Accepted Article.
Objective Though used frequently to treat flare, risk of chronic opioid exposure in gout has not been well defined. In this study, we examined the hypothesis that people with gout are more likely than individuals without gout to be prescribed chronic opioids over time.
Lindsay N. Helget, Bryant R. England, Punyasha Roul, Harlan Sayles, Tuhina Neogi, James R. O'Dell, Joshua F. Baker, Ted R. Mikuls   +7 more
wiley   +1 more source

The local and systemic effects of immune function on fracture healing

OTA International
. The immune system plays an integral role in the regulation of cellular processes responsible for fracture healing. Local and systemic influences on fracture healing correlate in many ways with fracture-related outcomes, including soft tissue healing ...
Andrew R. Evans, MD, Peter V. Giannoudis, BSc, MD, PhD, FRCS, FACS, Philip Leucht, MD, Todd O. McKinley, MD, Greg E. Gaski, MD, Katherine P. Frey, PhD, RN, Joseph C. Wenke, MD, Christopher Lee, MD   +7 more
doaj   +1 more source