Results 41 to 50 of about 1,704,060 (353)

Calcium and vitamin D in bone fracture healing and post-traumatic bone turnover.

European Cells & Materials, 2018
Calcium and vitamin D are essential for maintaining bone health. Therefore, deficiencies in calcium and vitamin D are major risk factors for osteoporosis development.
V. Fischer, M. Haffner-Luntzer, Michael Amling, Anita Ignatius   +3 more
semanticscholar   +1 more source

Methods to accelerate fracture healing – a narrative review from a clinical perspective

Frontiers in Immunology
Bone regeneration is a complex pathophysiological process determined by molecular, cellular, and biomechanical factors, including immune cells and growth factors.
Bergita Ganse, Bergita Ganse
doaj   +1 more source

Chronic psychosocial stress compromises the immune response and endochondral ossification during bone fracture healing via β-AR signaling

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Our results show that one single systemic administration of the β-adrenoreceptor blocker propranolol prior to femur osteotomy in psychosocially stressed mice prevents stress-induced bone marrow mobilization of neutrophils and their ...
M. Haffner-Luntzer, S. Foertsch, V. Fischer, Katja Prystaz, M. Tschaffon, Yvonne Mödinger, C. Bahney, R. Marcucio, T. Miclau, A. Ignatius, S. Reber   +10 more
semanticscholar   +1 more source

New Parameters Based on Ground Reaction Forces for Monitoring Rehabilitation Following Tibial Fractures and Assessment of Heavily Altered Gait

Sensors
Instrumented insoles have created opportunities for patient monitoring via long-term recordings of ground reaction forces (GRFs). As the GRF curve is altered in patients after lower-extremity fracture, parameters defined on established curve landmarks ...
Christian Wolff, Elke Warmerdam, Tim Dahmen, Tim Pohlemann, Philipp Slusallek, Bergita Ganse   +5 more
doaj   +1 more source

Animal models for studying metaphyseal bone fracture healing [PDF]

European Cells & Materials, 2020
An estimated 2 million osteoporotic fractures occur annually in the US, resulting in a dramatic reduction in quality of life for affected patients and a high economic burden for society.
M Haffner-Luntzer, A Ignatius
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Longitudinal weight and plantar pressure distribution while standing after tibial or malleolar fractures in patients with or without fracture union

Scientific Reports
Fracture healing is usually monitored by clinical impressions and radiographs. Objective and easy methods for assessing fracture healing without radiation would be beneficial. The aim of this study was to analyse whether weight and plantar pressure while
Elke Warmerdam, Sonja Baumgartner, Tim Pohlemann, Bergita Ganse   +3 more
doaj   +1 more source

Long-term continuous instrumented insole-based gait analyses in daily life have advantages over longitudinal gait analyses in the lab to monitor healing of tibial fractures

Frontiers in Bioengineering and Biotechnology
Introduction: Monitoring changes in gait during rehabilitation allows early detection of complications. Laboratory-based gait analyses proved valuable for longitudinal monitoring of lower leg fracture healing.
Elke Warmerdam, Christian Wolff, Marcel Orth, Tim Pohlemann, Bergita Ganse, Bergita Ganse   +5 more
doaj   +1 more source

NPY and CGRP Inhibitor Influence on ERK Pathway and Macrophage Aggregation during Fracture Healing

Cellular Physiology and Biochemistry, 2017
Aim: The aims of this study are to investigate the effects of neurotransmitters NPY and CGRP on ERK signaling in fracture healing, and to identify the correlation between macrophage aggregation and fracture healing. Methods: Male Sprague-Dawley rats were
Peng Tang, Chunguang Duan, Zheng Wang, ChunMei Wang, Guolin Meng, Kaifeng Lin, Qian Yang, Zhi Yuan   +7 more
doaj   +1 more source

Is sonic Hedgehog involved in human fracture healing? --a prospective study on local and systemic concentrations of SHH. [PDF]

PLoS ONE, 2014
INTRODUCTION: Sonic Hedgehog (SHH) is a new signalling pathway in bone repair. Evidence exist that SHH pathway plays a significant role in vasculogenesis and limb development during embryogenesis.
Stefan Eipeldauer, Anita Thomas, Leonard Hoechtl-Lee, Mathias Kecht, Harald Binder, Julia Koettstorfer, Markus Gregori, Kambiz Sarahrudi   +7 more
doaj   +1 more source