Results 111 to 120 of about 172,523 (297)

The Molecular Basis of Amino Acids Sensing

Advanced Science, EarlyView.
Amino acids are essential as protein building blocks and signaling molecules, enabling metabolic regulation. Cells sense amino acid levels to control protein synthesis, maintain homeostasis, and adapt to nutritional changes. This review explores recent advances in amino acid sensing mechanisms across organisms, highlighting their roles in cellular ...
Cong Jiang, Xiao Tan, Jiali Jin, Ping Wang   +3 more
wiley   +1 more source

Fragile X Mental Retardation Protein FMRP Binds mRNAs in the Nucleus [PDF]

Molecular and Cellular Biology, 2009
The fragile X mental retardation protein FMRP is an RNA binding protein that associates with a large collection of mRNAs. Since FMRP was previously shown to be a nucleocytoplasmic shuttling protein, we examined the hypothesis that FMRP binds its cargo mRNAs in the nucleus.
Stephanie Ceman, Miri Kim, Michel Bellini   +2 more
openaire   +3 more sources

On the origins of apparent fragile-to-strong transition of protein hydration waters [PDF]

, 2008
2H NMR is used to study the mechanisms for the reorientation of protein hydration water. In the past, crossovers in temperature-dependent correlation times were reported at T_x1=225K (X1) and T_x2=200K (X2). We show that neither X1 nor X2 are related to a fragile-to-strong transition. Our results rule out an existence of X1.
arxiv   +1 more source

The Structural Difference Between Strong and Fragile Liquids [PDF]

Journal of Non-Crystalline Solids X 13, 100080 (2022), 2023
A structural order parameter for disordered configurations is defined, based, not on local topologies, but on the degree of local restraint imposed on each atom. This restraint parameter provides a clear distinction between a strong liquid (SiO2) and a fragile liquid (a binary Lennard-Jones mixture) without reference to dynamics.
arxiv  

The impact of hydrodynamic interactions on protein folding rates depends on temperature [PDF]

Phys. Rev. E 97, 032402 (2018), 2017
We investigated the impact of hydrodynamic interactions (HI) on protein folding using a coarse-grained model. The extent of the impact of hydrodynamic interactions, whether it accelerates, retards, or has no effect on protein folding, has been controversial.
arxiv   +1 more source

Fragile X syndrome. [PDF]

, 2014
Fragile X Syndrome (FXS) is a genetic disease due to a CGG trinucleotide expansion, named full mutation (greater than 200 CGG repeats), in the fragile X mental retardation 1 gene locus Xq27.3; which leads to an hypermethylated region in the gene promoter
Ayala-Zapata, Sebastián, Forero-Forero, Jose Vicente, González-Teshima, Laura Yuriko, Hagerman, Randi, Saldarriaga, Wilmar, Tassone, Flora   +5 more
core   +1 more source

Synaptic vesicle dynamic changes in a model of fragile X [PDF]

, 2016
__Background:__ Fragile X syndrome (FXS) is a single-gene disorder that is the most common heritable cause of intellectual disability and the most frequent monogenic cause of autism spectrum disorders (ASD). FXS is caused by an expansion of trinucleotide
Bahn, S. (Sabine), Broek, A.C. (Jantine), Cappellen, W.A. (Gert) van, Cox, D. (David), Gruiter, H.M. (H. Martijn) de, Haasdijk, E.D. (Elize), Houtsmuller, A.B. (Adriaan), Lin, Z. (Zhanmin), Ozcan, S. (Sureyya), Spijker, H. (Heleen) van 't, Willemsen, R. (Rob), Zeeuw, C.I. (Chris) de   +11 more
core   +1 more source

Longitudinal Analysis of Neuroradiological Biomarkers for Fragile X‐Associated Tremor/Ataxia Syndrome and Implications for Clinical Trials

Annals of Neurology, EarlyView.
Objective The objective of this study was to show the capacity of structural brain magnetic resonance imaging (MRI) measures to serve as monitoring biomarkers for Fragile X‐Associated Tremor/Ataxia Syndrome (FXTAS). Methods From 2 longitudinal studies of male FMR1 premutation carriers, 2 brain MRI scans were selected from each participant, collected ...
David Hessl, Jun Yi Wang, Glenda Espinal, Ellery Santos, Flora Tassone, Randi J. Hagerman, Susan M. Rivera   +6 more
wiley   +1 more source

Understanding of the Retarded Oxidation Effects in Silicon Nanostructures [PDF]

Applied Physics Letters 100, 26 (2012) 263111, 2012
In-depth understanding of the retarded oxidation phenomenon observed during the oxidation of silicon nanostructures is proposed. The wet thermal oxidation of various silicon nanostructures such as nanobeams, concave/convex nanorings and nanowires exhibits an extremely different and complex behavior.
arxiv   +1 more source

FMRP regulates STAT3 mRNA localization to cellular protrusions and local translation to promote hepatocellular carcinoma metastasis

Communications Biology, 2021
Shen et al. propose a mechanism for the metastasis of hepatocellular carcinoma (HCC) cells through the localization and translation modulation of the STAT3 oncogene by fragile X mental retardation protein (FMRP).
Zhifa Shen, Bowen Liu, Biting Wu, Hongyin Zhou, Xiangyun Wang, Jinling Cao, Min Jiang, Yingying Zhou, Feixia Guo, Chang Xue, Zai-Sheng Wu   +10 more
doaj   +1 more source