Results 111 to 120 of about 28,649 (270)

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, EarlyView.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source

Fragile X Mental Retardation Protein FMRP Binds mRNAs in the Nucleus [PDF]

Molecular and Cellular Biology, 2009
The fragile X mental retardation protein FMRP is an RNA binding protein that associates with a large collection of mRNAs. Since FMRP was previously shown to be a nucleocytoplasmic shuttling protein, we examined the hypothesis that FMRP binds its cargo mRNAs in the nucleus.
Stephanie Ceman, Miri Kim, Michel Bellini   +2 more
openaire   +3 more sources

Fragile X Mental Retardation Protein expression in the retina is regulated by light. [PDF]

Exp Eye Res, 2016
Fragile X Mental Retardation Protein (FMRP) is a RNA-binding protein that modulates protein synthesis at the synapse and its function is regulated by glutamate. The retina is the first structure that participates in vision, and uses glutamate to transduce electromagnetic signals from light to electrochemical signals to neurons. FMRP has been previously
Guimarães-Souza EM, Perche O, Morgans CW, Duvoisin RM, Calaza KC.   +4 more
europepmc   +4 more sources

A comprehensive review on adaptive plasticity and recovery mechanisms post‐acquired brain injury

Neuroprotection, EarlyView.
This figure illustrates the dynamic process of neurogenesis following brain injury, focusing on the roles of neural stem and progenitor cells at the injury site. Key mechanisms include axonal sprouting, synaptogenesis, dendritic remodeling, and brain‐derived neurotrophic factor signaling via TrkB receptors.
Ravi Kumar Rajan
wiley   +1 more source

Fragile X Syndrome: Steps towards Therapy [PDF]

, 2013
In a continuously developing society we are still confronted with intellectual disability (ID) and autism around us with quite a high prevalence. 1 in 88 children is diagnosed with autism spectrum disorder (ASD), while 2-3% of the general population is
Pop, A.S. (Andreea)
core  

Epigenetic Characterization of the FMR1 Gene and Aberrant Neurodevelopment in Human Induced Pluripotent Stem Cell Models of Fragile X Syndrome [PDF]

, 2011
Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. In addition to cognitive deficits, FXS patients exhibit hyperactivity, attention deficits, social difficulties, anxiety, and other autistic-like behaviors.
A Bhattacharyya, A Maddalena, A Urbach, CJ Bontekoe, CJ Bontekoe, CT Ashley Jr, D Kumari, D Kumari, D Wohrle, DC Crawford, DH Geschwind, F Tassone, Fen Zhou, FO Walker, H Siomi, I Oberle, IH Park, J Itskovitz-Eldor, J Tost, Jeanne F. Loring, Jon M. Madison, JP Martin, JS Godde, JS Sutcliffe, K Brakensiek, K Braun, K Takahashi, Kraig M. Theriault, L Montermini, Laurence Daheron, LF Meisner, LL Rubin, LN Antar, M Castren, M Castren, Mark R. Cookson, N Maherali, O Penagarikano, R Eiges, RJ Hagerman, S Abraham, S Datta, S Jacquemont, S Ku, SD Sheridan, SL Nolin, Stephen J. Haggarty, Steven D. Sheridan, Surya A. Reis, V Campuzano, Y Feng, Y Luo, Y Soneoka   +52 more
core   +7 more sources

The research progress on the role of FMRP in the pathogenesis of tumors

Pifu-xingbing zhenliaoxue zazhi, 2023
Fragile X mental retardation protein (FMRP) is a selective RNA-binding protein that is highly expressed in neurons and influences cytoskeletal remodeling, cell-cell signal transduction and interactions.
Huizhi YANG, Sirui LI, Guiyue CAI, Jingwen ZOU, Junnan REN, Rongyi CHEN   +5 more
doaj   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Fragile X syndrome. [PDF]

, 2014
Fragile X Syndrome (FXS) is a genetic disease due to a CGG trinucleotide expansion, named full mutation (greater than 200 CGG repeats), in the fragile X mental retardation 1 gene locus Xq27.3; which leads to an hypermethylated region in the gene promoter
Ayala-Zapata, Sebastián, Forero-Forero, Jose Vicente, González-Teshima, Laura Yuriko, Hagerman, Randi, Saldarriaga, Wilmar, Tassone, Flora   +5 more
core   +1 more source

Histone modifications and FMR role in Fragile X syndrome: A review [PDF]

, 2023
Fragile X syndrome is the most common cause of genetically acquired mental disability and one of the most frequent single-gene disorders. FXS serves as an excellent model disorder for studies investigating disturbed molecular mechanisms and synapse ...
Debarati Roy Chowdhury, Pushanjali Bhat, Salmataj S A   +2 more
core   +3 more sources