Fragile X Mental Retardation Protein: To Be or Not to Be a Translational Enhancer [PDF]
Frontiers in Molecular Biosciences, 2018 Thomas Maurin +3 more
openaire +5 more sources
Fragile X Syndrome and Targeted Treatments [PDF]
Journal of Biomedicine and Translational Research, 2020 Many targeted treatment studies have been carried out in individuals with Fragile X Syndrome (FXS) guided by animal studies from the Fragile X Mental Retardation 1 (FMR1) knock out (KO) mice and the fragile X Drosophila studies.
Nattaporn Tassanakijpanich +3 more
doaj +3 more sources
The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95 [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2003 Peter K. Todd +2 more
openalex +2 more sources
A mouse model of the human Fragile X syndrome I304N mutation. [PDF]
PLoS Genetics, 2009 The mental retardation, autistic features, and behavioral abnormalities characteristic of the Fragile X mental retardation syndrome result from the loss of function of the RNA-binding protein FMRP.
Julie B Zang +11 more
doaj +5 more sources
Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNA [PDF]
Elife, 2018 Subgenomic flaviviral RNA (sfRNA) accumulates during infection due to incomplete degradation of viral genomes and interacts with cellular proteins to promote infection. Here we identify host proteins that bind the Zika virus (ZIKV) sfRNA.
Ruben Soto-Acosta +7 more
semanticscholar +2 more sources
The tandem Agenet domain of fragile X mental retardation protein interacts with FUS [PDF]
Scientific Reports, 2017 The tandem Agenet domain (TAD) of fragile X mental retardation protein (FMRP) protein is considered to be a member of the methyl-lysine-binding Tudor domain “Royal family”.
Qingzhong He, Wei Ge
doaj +2 more sources
The fragile X mental retardation protein regulates tumor invasiveness-related pathways in melanoma cells [PDF]
Cell Death Dis, 2017 The fragile X mental retardation protein (FMRP) is lacking or mutated in patients with the fragile X syndrome (FXS), the most frequent form of inherited intellectual disability. FMRP affects metastasis formation in a mouse model for breast cancer.
F. Zalfa +21 more
semanticscholar +2 more sources
Gene therapy using an ortholog of human fragile X mental retardation protein partially rescues behavioral abnormalities and EEG activity [PDF]
Mol Ther Methods Clin Dev, 2021 Alexander W. M. Hooper +8 more
semanticscholar +2 more sources
Fragile X mental retardation protein: from autism to neurodegenerative disease [PDF]
Frontiers in Cellular Neuroscience, 2015 Fragile X mental retardation protein (FMRP) is a RNA binding protein, the absence of which due to silencing of the FMR1 gene causes fragile X syndrome, an X-linked neurodevelopmental disorder (Bassell and Warren, 2008; Bhakar et al., 2012; Santoro et al., 2012). FMRP regulates the transport, stability and translation of its mRNA targets.
Hansen eWang
doaj +4 more sources