Results 91 to 100 of about 7,289,232 (294)

From cancer prevention to survivorship: Comprehensive menopause management after risk‐reducing salpingo‐oophorectomy

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Risk‐reducing salpingo‐oophorectomy (RRSO) is the cornerstone of ovarian cancer prevention for women with hereditary cancer predisposition syndromes. When performed before natural menopause, however, RRSO induces immediate surgical menopause, with vasomotor symptoms, sexual dysfunction, accelerated bone loss, and potential long‐term ...
Agnaldo Lopes da Silva Filho, Giovanni Grandi, Teresa Lamaita Lopes, Matheus Eduardo Soares Pinhati, Angélica Nogueira Rodrigues, Fernando Cotait Maluf, Eduardo Batista Cândido, Rívia Mara Lamaita   +7 more
wiley   +1 more source

Síndrome frágil X Fragile X Syndrome

Revista Cubana de Investigaciones Biomédicas, 2007
Se efectuó una revisión sobre el síndrome frágil X, del cual en Cuba no existían reportes desde el punto de vista poblacional, hasta la realización del estudio psicopedagógico, social y clínico genético de las personas con retraso mental; mediante el ...
doaj  

Addressing the Abundance Paradox Through Topology‐Guided Graph Learning for Cross‐Cohort Classification of Type 2 Diabetes

iMetaMed, EarlyView.
By shifting from highly variable taxonomic abundance to conserved ecological network topologies, our Dual‐Stream Graph Attention Network (DS‐GAT‐CP) resolves the “abundance paradox,” enabling highly accurate and cross‐regionally robust non‐invasive screening for Type 2 Diabetes. ABSTRACT Gut microbiome‐based machine learning models for Type 2 Diabetes (
Changjian Wu, Ping Wei, Xuhui Wang, Hua Hua, Junli Li   +4 more
wiley   +1 more source

Towards Mechanism-Based Treatments for Fragile X Syndrome

Brain Sciences, 2019
Fragile X syndrome (FXS) is the most common heritable form of intellectual disability, as well as the most common known monogenic cause of autism spectrum disorder (ASD), affecting 1 in 4000−8000 people worldwide [...]
Daman Kumari, Inbal Gazy
doaj   +1 more source

Progress toward therapeutic potential for AFQ056 in Fragile X syndrome

, 2013
Mary Sourial, Connie Cheng, Laurie C Doering Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada Abstract: Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the leading ...
Cheng C, Sourial M, Doering LC
core  

Glycogen Synthase Kinase-3: Abnormalities and Therapeutic Potential in Fragile X Syndrome

, 2017
Recent advances in understanding the pathophysiological mechanisms contributing to fragile X syndrome (FXS) have increased optimism that drug interventions can provide significant therapeutic benefits.
Jope, Richard S, Richard S. Jope
core   +1 more source

Phenotypic and Genotypic Analysis of Two Rare Cases of ‐‐SEA/‐α4.3 HbH Disease

Journal of Clinical Laboratory Analysis, EarlyView.
We report two unrelated adult patients with rare deletional HbH disease (genotype ‐‐SEA/‐α4.3). This novel 4.3 kb deletion covering the HBA1 gene is accompanied by X‐Y‐Z segment recombination, which was identified by CycloneSEQ long‐read nanopore sequencing.
Weijia Yang, Xiaoyan Huang, Li Zhang, Xiaoqin Yang, Yaya Guo, Qingping Kang, Min Dou, Guijun Huang   +7 more
wiley   +1 more source

Hyperactivity, perseveration and increased responding during attentional rule acquisition in the Fragile X mouse model

Frontiers in Behavioral Neuroscience, 2013
Attentional deficits and executive function impairments are common to many neurodevelopmental disorders of intellectual disability and autism, including Fragile X syndrome.
Ioannis eKramvis, Ioannis eKramvis, Huibert eMansvelder, Maarten eLoos, Maarten eLoos, Rhiannon eMeredith   +5 more
doaj   +1 more source

Fragile X (Martin Bell) Syndrome

, 2002
Fragile X syndrome is a neurodevelopmental disorder that results from a single gene mutation on the X chromosome. It is the most common genetic cause of learning disability, though many patients remain unrecognized.
Crispian Scully
core   +1 more source

Infant frontal alpha asymmetry predicts social attention and transdiagnostic risk for emotional reactivity

JCPP Advances, EarlyView.
Abstract Background Differences in Frontal Alpha Asymmetry (FAA), derived from the electroencephalogram (EEG), have been associated with approach‐withdrawal behavior, although inconsistently. The current study examined how early patterns of FAA during the first 2 years of life relate to various socioemotional characteristics (at 2 years) and ultimately
Viviane Valdes, Niccola Lutri, Haerin Chung, Charles A. Nelson   +3 more
wiley   +1 more source