Results 41 to 50 of about 94,498 (240)

Fragile male, not fragile-X [PDF]

Advances in Psychiatric Treatment, 2008
No doubt the fragile-X chromosome plays a small part in male disadvantage, but the point made in my review ([Kraemer, 2000][1]), referred to by [Branney & White (2008)][2], is that the male is biologically less resilient.
openaire   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Gel and glass transition in fragile colloidal clays

Condensed Matter Physics, 2019
Dynamic Light Scattering (DLS) measurements were performed on colloidal suspensions of Laponite® at different concentrations in the range C_w = (1.5÷3.0)%.
R. Angelini, G. Ruocco, B. Ruzicka
doaj   +1 more source

The role of Christianity in mending societal fragility and quelling violence in Liberia

Verbum et Ecclesia, 2017
This article has benefited from the research entitled The role of Christianity in post-war Liberia . It is a study that attempts to examine and investigate how Christian faith and spirituality can play a role in a campaign for social peace, justice ...
Eric Gbotoe, Selaelo T. Kgatla
doaj   +1 more source

The determinants of the quality of clinical management among diabetic and hypertensive patients in a context of fragility: A cross-sectional survey from Lebanon

Frontiers in Public Health, 2022
IntroductionThe management of NCDs is a growing challenge in low- and middle-income settings with the increasing prevalence and the associated demands that such conditions make on health systems.
Shadi Saleh, Shadi Saleh, Dina Muhieddine, Randa Hamadeh, Hani Dimassi, Karin Diaconu, Stella Arakelyan, Alastair Ager, Mohamad Alameddine   +8 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Editorial for Special Issue “Exclusive Papers of the Editorial Board Members of Oral”

Oral
In 2022, the World Health Organization (WHO) released a landmark report on oral health, emphasizing the staggering global prevalence of oral disorders, which affect approximately 3 [...]
Giuseppina Campisi
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Animal Death and Religion: Revisiting Creaturely Vulnerability, Mourning and Sacrifice

Zoophilologica, 2019
Choć kwestia zwierzęcej śmierci i umierania od dawna zwraca uwagę badaczy z kręgu animal studies, coraz częstsze jej pojawianie się w obszarze studiów religioznawczych jest zjawiskiem interesującym i stosunkowo nowym, które domaga się rozważenia.
Alina Mitek-Dziemba
doaj   +1 more source