Results 91 to 100 of about 297,713 (300)

Financial Development and Fragility: A Clustering Analysis

This paper explores the potential correlations between financial development and state fragility, using a sample of 137 countries observed over the period from 1998–2019. The countries are grouped into clusters that capture the different joint states of financial development and fragility. The
João, Igor Custodio, Calice, Pietro, Lucas, Andre, Schaumburg, Julia   +3 more
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Structure and temporal change of the credit network between banks and large firms in Japan [PDF]

, 2009
We present a new approach to understanding credit relationships between commercial banks and quoted firms, and with this approach, examine the temporal change in the structure of the Japanese credit network from 1980 to 2005.
Aoyama, Hideaki, Fujiwara, Yoshi, Ikeda, Yuichi, Iyetomi, Hiroshi, Souma, Wataru   +4 more
core   +3 more sources

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Seismic Performance and Collapse Fragility of a 765 kV Transmission Tower–Line System

Buildings
Based on a real-world project in Pakistan, this study investigates the seismic performance and collapse fragility of a 765 kV transmission tower–line system.
Guo-Dong Shao, Cong Xiao, Ming-Xuan Zhu, Farooq Syed Hassan, Chuan-Sai Ma, Shao-Yuan Zhang, Li Tian   +6 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Development of fragility curves for tuned mass damper inerter (TMDI) systems under pulse-like ground motions from the 2024 Noto earthquake (Mw 7.6)

Frontiers in Built Environment
Enhancing seismic resilience in the built environment is essential for safeguarding structures in earthquake-prone regions. Inerter-based vibration control systems represent an important advancement in earthquake engineering, yet their effectiveness ...
Madhu Beerabbi Eshapurada, K. S. K. Karthik Reddy   +1 more
doaj   +1 more source

Dependence of the fragility of a glass former on the softness of interparticle interactions

, 2011
We study the influence of the softness of the interparticle interactions on the fragility of a glass former, by considering three model binary mixture glass formers.
Affouard, Frédéric, Sastry, Srikanth, Sengupta, Shiladitya, Vasconcelos, Filipe   +3 more
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source