Results 91 to 100 of about 96,454 (308)
Seismic Performance and Collapse Fragility of a 765 kV Transmission Tower–Line System
BuildingsBased on a real-world project in Pakistan, this study investigates the seismic performance and collapse fragility of a 765 kV transmission tower–line system.
Guo-Dong Shao +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Financial Fragility and Economic Fluctuations: Numerical Simulations and Policy Implications [PDF]
This paper proposes a simple prototype model that describes the complex dynamics of a sophisticated monetary economy. The interaction between the current and intertemporal financial constraints of economic units brings about irregular fluctuations at the
Alessandro Vercelli, Serena Sordi
core
Frontiers in Built EnvironmentEnhancing seismic resilience in the built environment is essential for safeguarding structures in earthquake-prone regions. Inerter-based vibration control systems represent an important advancement in earthquake engineering, yet their effectiveness ...
Madhu Beerabbi Eshapurada +1 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2020 BACKGROUND Osteoporosis is characterised by low bone mass and structural deterioration of bone tissue, with a consequent increase in susceptibility to fragility fracture.
Jean Sanderson (2758504) +5 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Growth, History, or Institutions? What Explains State Fragility in Sub-Saharan Africa [PDF]
We explore the determinants of state fragility in sub-Saharan Africa. Controlling for a wide range of economic, demographic, geographic and istitutional regressors, we find that institutions, and in particular the civil liberties index and the number of ...
Graziella Bertocchi, Andrea Guerzoni
core
A Fragility Framework for Surface Erosion With Application to Earthen Dam Breaching
Water Resources ResearchOvertopping failures of earthen dams are a growing concern under intensifying extreme rainfall. This study introduces a probabilistic fragility framework that combines hydrologic modeling, hydraulic analysis, and soil erodibility to assess erosion risk ...
Ege C. Kurter +3 more
doaj +1 more source
Financial Reforms and Financial Fragility: A Panel Data Analysis [PDF]
International Journal of Financial Studies, 2015 This paper explores the relationship between financial reforms, financial liberalization and the quality of banking regulation and supervision for financial fragility by applying a dynamic two-step system generalized method of moments GMM panel estimator technique.
openaire +3 more sources