Results 71 to 80 of about 22,163,095 (343)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

State fragility and economic vulnerability: what is measured and why? [PDF]

State fragility is a concept that emerged among the international community of donors in order to adapt aid policies to particularly difficult situations.
Sylviane GUILLAUMONT JEANNENEY, Patrick GUILLAUMONT   +1 more
core   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Longitudinal seismic fragility analysis of utility tunnel structures based on IDA method

Yantu gongcheng xuebao
This study aims to propose a fragility analysis method for evaluating the longitudinal seismic performance of long-line utility tunnels based on nonlinear incremental dynamic analysis (IDA).
LI Jinqiang , ZHONG Zilan , SHEN Jiaxu , ZHANG Bu , ZHANG Yabo , DU Xiuli
doaj   +1 more source

Financial Development and Fragility: A Clustering Analysis

This paper explores the potential correlations between financial development and state fragility, using a sample of 137 countries observed over the period from 1998–2019. The countries are grouped into clusters that capture the different joint states of financial development and fragility.
João, Igor Custodio, Calice, Pietro, Lucas, Andre, Schaumburg, Julia   +3 more
openaire   +3 more sources

"Measuring Macroprudential Risk: Financial Fragility Indexes" [PDF]

With the Great Recession and the regulatory reform that followed, the search for reliable means to capture systemic risk and to detect macrofinancial problems has become a central concern.
Éric Tymoigne
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Governing the Intelligence Loop: Architectural Mitigations for Epistemic Fragility in Autonomous Space-Cyber Threat Analysis

Khadija Taki
  +6 more sources

Influence of Ground-Motion Intensity Measure Selection on Bayesian Fragility Analysis of RCS Frame Structures

Buildings
This study focuses on RCS frame structures and selects six different types of ground-motion intensity measures (IMs), including peak ground acceleration (PGA), spectral acceleration at the fundamental period Sa(T1), the modified intensity measure S ...
Yantai Zhang, Jun Ma, Jingwen Gao, Hao Wu, Tingting Liu   +4 more
doaj   +1 more source

Stochastic Vulnerability Assessment of Masonry Structures: Concepts, Modeling and Restoration Aspects

Applied Sciences, 2019
A methodology aiming to predict the vulnerability of masonry structures under seismic action is presented herein. Masonry structures, among which many are cultural heritage assets, present high vulnerability under earthquake.
Panagiotis G. Asteris, Antonia Moropoulou, Athanasia D. Skentou, Maria Apostolopoulou, Amin Mohebkhah, Liborio Cavaleri, Hugo Rodrigues, Humberto Varum   +7 more
doaj   +1 more source