Results 71 to 80 of about 96,454 (308)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Strategic Complementarity, Fragility, and Regulation [PDF]

The paper analyzes a very stylized model of crises and demonstrates how the degree of strategic complementarity in the actions of investors is an important determinant of fragility.
Xavier Vives
core   +2 more sources

Influence of Ground-Motion Intensity Measure Selection on Bayesian Fragility Analysis of RCS Frame Structures

Buildings
This study focuses on RCS frame structures and selects six different types of ground-motion intensity measures (IMs), including peak ground acceleration (PGA), spectral acceleration at the fundamental period Sa(T1), the modified intensity measure S ...
Yantai Zhang, Jun Ma, Jingwen Gao, Hao Wu, Tingting Liu   +4 more
doaj   +1 more source

Financial Development and Fragility: A Clustering Analysis

This paper explores the potential correlations between financial development and state fragility, using a sample of 137 countries observed over the period from 1998–2019. The countries are grouped into clusters that capture the different joint states of financial development and fragility.
João, Igor Custodio, Calice, Pietro, Lucas, Andre, Schaumburg, Julia   +3 more
openaire   +3 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

"Measuring Macroprudential Risk: Financial Fragility Indexes" [PDF]

With the Great Recession and the regulatory reform that followed, the search for reliable means to capture systemic risk and to detect macrofinancial problems has become a central concern.
Éric Tymoigne
core  

Assessing the impact of ground-motion variability and uncertainty on empirical fragility curves [PDF]

, 2015
Empirical fragility curves, constructed from databases of thousands of building-damage observations, are commonly used for earthquake risk assessments, particularly in Europe and Japan, where building stocks are often difficult to model analytically (e.g.
Rossetto, T, Douglas, J, Ioannou, I, Rossetto, Tiziana, Ioannou, Ioanna, Douglas, John   +5 more
core   +1 more source

Fragility curves as a handy forecasting method

, 2022
The fragility curves method, which is commonly used in the prediction of damage associated with a certain earthquake intensity, is here extended as an agile and handy method, able to oer a reliable forecast of the evolution of deterioration process for
R. Pavani, Sgambi, Luca, ICNAAM 2020 INTERNATIONAL CONFERENCE OF NUMERICAL ANALYSIS AND APPLIED MATHEMATICS, Pavani, Raffaella, E. Garavaglia, L. Sgambi, Garavaglia, Elsa   +6 more
core   +1 more source

The Performance of Large Diameter Threaded Cast Iron Pipe Fitting Joints Used in a Fire Suppression System: Experimental and Fragility Analysis

Journal of Experimental and Theoretical Analyses
Threaded cast iron fittings, including tees and elbows, are commonly used in fire suppression systems to connect piping components due to their simplicity, reliability, and compatibility with National Pipe Thread (NPT) standards.
Cameron Rusnak, Sherif Elfass, Allen Rivas   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source