Results 61 to 70 of about 96,454 (308)

Modelling and Characterizing a Concrete Gravity Dam for Fragility Analysis [PDF]

Infrastructures, 2019
Most gravity dams have been designed and built during the past century with methods of analysis that are now considered inadequate. In recent decades, knowledge of seismology, structural dynamics and earthquake engineering has greatly evolved, leading to the evaluation of existing dams to ensure public safety.
Rocio L. Segura, Carl Bernier, Capucine Durand, Patrick Paultre   +3 more
openaire   +3 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Dundee Discussion Papers in Economics 185:Extracting leading indicators of bank fragility from market prices: Estonia focus [PDF]

, 2005
Banking reform has proved to be one of the most problematic elements of economic transition in central and eastern Europe. Therefore the paper considers the development of the Estonian banking sector and derives individual banks´ fragility scores during ...
Mannasoo, Kadri, Chen, Yu-Fu, Funke, Michael   +2 more
core  

Seismic Fragility Analysis of Existing Old Newari Brick Masonry Building in Pokhara Valley

Structural Mechanics of Engineering Constructions and Buildings
Most of the building stock in Nepal is based on masonry construction, which includes monumental, administrative, and residential structures. These structures are vulnerable during earthquakes, as evidenced by the massive structural damage, loss of human ...
Krishna Chapagain, Hemchandra Chaulagain
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Fragility Analysis of Power Transmission Tower Subjected to Wind–Sand Loads

Energies
With the increasing construction of power transmission towers in desert regions for the transportation of wind or solar energy, structural safety under wind and sand loads has become critical.
Xiaoqian Ma, Jun Lu, Benliang Li, Weiguang Tian, Yaxiao Zhang, Peng Zhang   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Stochastic Vulnerability Assessment of Masonry Structures: Concepts, Modeling and Restoration Aspects

Applied Sciences, 2019
A methodology aiming to predict the vulnerability of masonry structures under seismic action is presented herein. Masonry structures, among which many are cultural heritage assets, present high vulnerability under earthquake.
Panagiotis G. Asteris, Antonia Moropoulou, Athanasia D. Skentou, Maria Apostolopoulou, Amin Mohebkhah, Liborio Cavaleri, Hugo Rodrigues, Humberto Varum   +7 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Longitudinal seismic fragility analysis of utility tunnel structures based on IDA method

Yantu gongcheng xuebao
This study aims to propose a fragility analysis method for evaluating the longitudinal seismic performance of long-line utility tunnels based on nonlinear incremental dynamic analysis (IDA).
LI Jinqiang , ZHONG Zilan , SHEN Jiaxu , ZHANG Bu , ZHANG Yabo , DU Xiuli
doaj   +1 more source