Results 61 to 70 of about 22,163,095 (343)

Adaptive artificial neural networks for seismic fragility analysis [PDF]

2017 2nd International Conference on System Reliability and Safety (ICSRS), 2017
In seismic probabilistic risk assessment, fragility curves are used to estimate the probability of failure of a structure or its critical components at given values of seismic intensity measures, e.g. the peak ground acceleration. However, the computation of the fragility curves requires a large number of time-consuming mechanical simulations with the ...
Wang, Zhiyi, Zentner, Irmela, Pedroni, Nicola, Zio, Enrico   +3 more
openaire   +5 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Methodical Investigations on Seismic Retrofitting of Steel Plate Shear Wall Systems

Buildings
An efficient retrofitting technique is expected to improve the seismic performance of a lateral force-resisting system without increasing the seismic demand on the structure, which can unfavorably lead to irreparable damages during a seismic event.
Tadeh Zirakian
doaj   +1 more source

Seismic Fragility Assessment of Steel SMRF Structures under Various Types of Near and Far Fault Ground Motions [PDF]

Journal of Rehabilitation in Civil Engineering, 2019
In this paper, the seismic collapse probability of special steel moment-resisting frame (SSMRF) structures, designed to 4th edition of Iranian seismic design code, under near fault pulse-like and far fault ordinary ground motions is evaluated through ...
Morteza Razi, Mohsen Gerami, Reza Vahdani, Farhang Farrokhshahi   +3 more
doaj   +1 more source

Modelling and Characterizing a Concrete Gravity Dam for Fragility Analysis [PDF]

Infrastructures, 2019
Most gravity dams have been designed and built during the past century with methods of analysis that are now considered inadequate. In recent decades, knowledge of seismology, structural dynamics and earthquake engineering has greatly evolved, leading to the evaluation of existing dams to ensure public safety.
Rocio L. Segura, Carl Bernier, Capucine Durand, Patrick Paultre   +3 more
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Seismic Fragility Analysis of Existing Old Newari Brick Masonry Building in Pokhara Valley

Structural Mechanics of Engineering Constructions and Buildings
Most of the building stock in Nepal is based on masonry construction, which includes monumental, administrative, and residential structures. These structures are vulnerable during earthquakes, as evidenced by the massive structural damage, loss of human ...
Krishna Chapagain, Hemchandra Chaulagain
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Fragility Analysis of Power Transmission Tower Subjected to Wind–Sand Loads

Energies
With the increasing construction of power transmission towers in desert regions for the transportation of wind or solar energy, structural safety under wind and sand loads has become critical.
Xiaoqian Ma, Jun Lu, Benliang Li, Weiguang Tian, Yaxiao Zhang, Peng Zhang   +5 more
doaj   +1 more source