Results 81 to 90 of about 297,713 (300)

Fragility Analysis of Power Transmission Tower Subjected to Wind–Sand Loads

Energies
With the increasing construction of power transmission towers in desert regions for the transportation of wind or solar energy, structural safety under wind and sand loads has become critical.
Xiaoqian Ma, Jun Lu, Benliang Li, Weiguang Tian, Yaxiao Zhang, Peng Zhang   +5 more
doaj   +1 more source

Tsunami fragility curves of a RC structure through different analytical methods [PDF]

, 2016
Recent tsunami events have stimulated research activity into tsunami fragility functions which have been largely based on empirical data. However, empirical fragility functions are biased because the influence of earthquake and tsunami damage are ...
Eames, Ian, Goda, Katsu, Petrone, Crescenzo, Rossetto, Tiziana   +3 more
core  

A NLO analysis on fragility of dihadron tomography in high energy $AA$ collisions

, 2008
The dihadron spectra in high energy $AA$ collisions are studied within the NLO pQCD parton model with jet quenching taken into account. The high $p_T$ dihadron spectra are found to be contributed not only by jet pairs close and tangential to the surface ...
Enke Wang, Hanzhong Zhang, J F Owens, Winter D L, Xin-Nian Wang, Zhang H Z Owens J F Wang E Wang X-N   +5 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Longitudinal seismic fragility analysis of utility tunnel structures based on IDA method

Yantu gongcheng xuebao
This study aims to propose a fragility analysis method for evaluating the longitudinal seismic performance of long-line utility tunnels based on nonlinear incremental dynamic analysis (IDA).
LI Jinqiang , ZHONG Zilan , SHEN Jiaxu , ZHANG Bu , ZHANG Yabo , DU Xiuli
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Seismic Fragility Analysis of Shield Tunnels Considering the Flexural Capacity of Longitudinal Joints

Buildings
The longitudinal joints in shield tunnels connect the segments in a ring and can predominantly influence the mechanical behavior of the lining. The axial force environment influences the flexural capacity of longitudinal joints in shield tunnels and is a
Guochen Zhao, Zheng Yang, Jingzhou Zhu, Shibin Lin, Yujin Wang   +4 more
doaj   +1 more source

High serum osteopontin levels are associated with prevalent fractures and worse lipid profile in post-menopausal women with type 2 diabetes [PDF]

, 2018
Purpose: Patients with type 2 diabetes (T2DM) have increased fracture risk. Osteopontin (OPN) is a protein involved in bone remodeling and inflammation.
Carnevale, V., Filardi, Tiziana, Lenzi, A., Massoud, R., Morano, S., Nieddu, L., Romagnoli, E., Russo, C., Tavaglione, F., Turinese, Irene   +9 more
core   +1 more source