Results 51 to 60 of about 54,055 (308)
Stochastic approach for analytical fragility curves
KSCE Journal of Civil Engineering, 2008 One of the main problems is the assessment of “residual reliability” or “vulnerability” of a single existing structure, or of a given class of similar structures, against seismic actions. The fragility curves describe the probability of a structure to suffer a given damage level when it is subject to a given seismic excitation level. This research work
MARANO, Giuseppe Carlo +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Moldels for reproducing the damage scenario of the Lorca earthquake [PDF]
, 2014 A damage scenario modelling is developed and compared with the damage distribution observed after the 2011 Lorca earthquake. The strong ground motion models considered include five modern ground motion prediction equations (GMPEs) amply used worldwide ...
Gaspar-Escribano, Jorge M. +3 more
core +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Tsunami fragility curves of a RC structure through different analytical methods [PDF]
, 2016 Recent tsunami events have stimulated research activity into tsunami fragility functions which have been largely based on empirical data. However, empirical fragility functions are biased because the influence of earthquake and tsunami damage are ...
Eames, Ian +3 more
core
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Municipal expected annual loss as an indicator to develop seismic risk maps in Italy [PDF]
, 2019 This work presents a risk-targeted indicator called Municipal Expected Annual Loss (MEAL) for a quantitative estimation of the seismic risk at territorial level.
Faleschini, Flora +4 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Seismic Vulnerability of Chemical Racks in the Cross-Aisle Direction [PDF]
, 2014 Information on the seismic response of chemical containers located in storage racks is very limited. Unfortunately, no clearly established data and statistics exist related to potential damage of chemical racking systems during earthquakes.
ARCIDIACONO VINCENZO +2 more
core +1 more source
THE DISTRIBUTION CURVE OF ERYTHROCYTE FRAGILITY [PDF]
Blood, 1949 Abstract 1. A simple method of representing erythrocyte fragility as a distribution curve of actual cellular fragility is described. 2. The importance of deciding the form of a distribution before using summarizing statistics is emphasized. 3.
openaire +1 more source