Beyond the Fragility Index. [PDF]
Pharm StatThe results of randomized clinical trials (RCTs) are frequently assessed with the fragility index (FI). Although the information provided by FI may supplement the p value, this indicator presents intrinsic weaknesses and shortcomings. In this article, we
Quatto P, Ripamonti E, Marasini D.
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Fragility index and fragility quotient in randomized clinical trials. [PDF]
J Bras Pneumol, 2023 1. Cleveland Clinic Foundation, Cleveland (OH) USA. 2. Divisão de Pneumologia, Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP) Brasil. 3. Unidade de Terapia Intensiva, AC Camargo Cancer Center,
Garcia MVF, Ferreira JC, Caruso P.
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Statistics in Brief: The Fragility Index. [PDF]
Clin Orthop Relat Res, 2023 There is a crisis of replicability in science [3], including in clinical research [4]. One possible cause of this is a concept called “statistical fragility” [30].
Stern BZ, Poeran J.
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Fragility index of positive phase II and III randomised clinical trials of treatments for hepatocellular carcinoma (2002–2022) [PDF]
JHEP Reports, 2023 Background & Aims: The fragility index (FI), i.e., theminimum number of best survivors reassigned to the control group required to revert the statistically significant result of a clinical trial to non-significant, is a metric to evaluate the ...
Sabrina Sidali +8 more
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Assessing the robustness of results from clinical trials and meta-analyses with the fragility index [PDF]
American Journal of Obstetrics and Gynecology, 2023 The fragility index (FI) has been increasingly used to assess the robustness of the results of clinical trials since 2014. It aims at finding the smallest number of event changes that could alter originally statistically significant results.
Luis Sanchez-Ramos +2 more
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Fragility Index as a Measure of Randomized Clinical Trial Quality in Adult Reconstruction: A Systematic Review [PDF]
Arthroplasty Today, 2021 Background The Fragility Index (FI) and Reverse Fragility Index are powerful tools to supplement the P value in evaluation of randomized clinical trial (RCT) outcomes.
Anastasia Gazgalis +2 more
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Nonattainability of the Fragility Index. [PDF]
CureusBackground: The fragility index (FI) is intended to quantify how many outcome changes would be required to convert a statistically significant two-arm trial result into a nonsignificant one. A reliable statistical metric should produce a result for every
Heston TF.
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The fragility index can be used for sample size calculations in clinical trials [PDF]
Journal of Clinical Epidemiology, 2021 Objective: The fragility index is a clinically interpretable metric increasingly used to interpret the robustness of clinical trials results that is generally not incorporated in sample size calculation and applied post-hoc.
Mary Charlson, Stephen Fremes
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Paediatric surgical trials, their fragility index, and why to avoid using it to evaluate results [PDF]
Pediatric Surgery International, 2022 The fragility index has been gaining ground in the evaluation of comparative clinical studies. Many scientists evaluated trials in their fields and deemed them to be fragile, although there is no consensus on the definition of fragility.
Christina Oetzmann von Sochaczewski +2 more
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How Fragile Are the Results of a Trial? The Fragility Index. [PDF]
Global Spine J, 2020 In an earlier article, we cautioned against overemphasizing the importance of the P-value. We argued that the P-value was just one tool in the toolbox for interpreting the results of a study. One should also consider the size of the effect and define and
Dettori JR, Norvell DC.
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