Results 11 to 20 of about 4,896,431 (278)
The Percent Fragility Index [PDF]
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, 2023 This article proposes the Percent Fragility Index (PFI) as an improved measure of statistical fragility in biomedical research. The PFI quantifies the percentage change in outcomes needed to change a study's statistical significance from positive to negative or vice-versa.
Thomas F Heston, Heston, Thomas
core +6 more sources
A critique of the fragility index
The Lancet Oncology, 2019 In The Lancet Oncology , Joseph Del Paggio and Ian Tannock report on a retrospective analysis of the fragility indices of phase 3 trials used by the US Food and Drug Administration (FDA) to approve anticancer drugs. 1 The authors conclude that “many phase 3 randomised controlled trials supporting FDA-approved anticancer drugs have a low fragility index,
Machado, Tiago +4 more
core +8 more sources
Assessing and visualizing fragility of clinical results with binary outcomes in R using the fragility package [PDF]
PLoS ONE, 2022 With the growing concerns about research reproducibility and replicability, the assessment of scientific results’ fragility (or robustness) has been of increasing interest.
Lifeng Lin, Haitao Chu
doaj +3 more sources
Fragility exposure index: Concepts, measurement, and application [PDF]
Review of Development Economics, 2022 AbstractDefinitions of fragility are focused at the level of the state, but this should not be considered to suggest that individuals with heterogeneous endowments experience a state of fragility in the same way. Nor does it suggest that all subregions of a fragile country exist in this state.
Ghassan Baliki +3 more
openaire +4 more sources
Nonattainability of the Fragility Index. [PDF]
CureusThe fragility index (FI) is intended to quantify how many outcome changes would be required to convert a statistically significant two-arm trial result into a nonsignificant one. A reliable statistical metric should produce a result for every valid case it evaluates.
Heston TF.
europepmc +3 more sources
Beyond the Fragility Index. [PDF]
Pharm StatABSTRACTThe results of randomized clinical trials (RCTs) are frequently assessed with the fragility index (FI). Although the information provided by FI may supplement the p value, this indicator presents intrinsic weaknesses and shortcomings. In this article, we establish an analysis of fragility within a broader framework so that it can reliably ...
Quatto P, Ripamonti E, Marasini D.
europepmc +4 more sources
Statistics in Brief: The Fragility Index. [PDF]
Clin Orthop Relat Res, 2023 Stern BZ, Poeran J.
europepmc +3 more sources
Fragility index and fragility quotient in randomized clinical trials. [PDF]
J Bras Pneumol, 2023 Garcia MVF, Ferreira JC, Caruso P.
europepmc +3 more sources
Fragility Index as a Measure of Randomized Clinical Trial Quality in Adult Reconstruction: A Systematic Review [PDF]
Arthroplasty Today, 2021 Anastasia Gazgalis +2 more
exaly +2 more sources
How Fragile Are the Results of a Trial? The Fragility Index. [PDF]
Global Spine J, 2020 Dettori JR, Norvell DC.
europepmc +4 more sources