The Percent Fragility Index [PDF]
SSRN Electronic Journal, 2023 This article proposes the Percent Fragility Index (PFI) as an improved measure of statistical fragility in biomedical research. The PFI quanties the percentage change in outcomes needed to change a study's statistical signicance from positive to ...
Thomas F. Heston
semanticscholar +7 more sources
Empirical assessment of fragility index based on a large database of clinical studies in the Cochrane Library [PDF]
Journal of Evaluation in Clinical Practice, 2023 Rationale aims and objectives: The fragility index (FI) and fragility quotient (FQ) are increasingly used measures for assessing the robustness of clinical studies with binary outcomes in terms of statistical significance. The FI is the minimum number of
Xing A, Lin L.
exaly +3 more sources
Fragility exposure index: Concepts, measurement, and application [PDF]
Review of Development Economics, 2022 AbstractDefinitions of fragility are focused at the level of the state, but this should not be considered to suggest that individuals with heterogeneous endowments experience a state of fragility in the same way. Nor does it suggest that all subregions of a fragile country exist in this state.
Sindu Kebede +2 more
exaly +5 more sources
Fragility Index in Cardiovascular Randomized Controlled Trials [PDF]
Circulation: Cardiovascular Quality and Outcomes, 2019 BACKGROUND: Efficacy of an intervention is commonly evaluated using P values, in addition to effect size measures such as absolute risk reduction, relative risk reduction, and numbers needed to treat.
John Mandrola +2 more
exaly +4 more sources
Statistical Significance Versus Clinical Relevance: A Head-to-Head Comparison of the Fragility Index and Relative Risk Index. [PDF]
Cureus, 2023 Background In biostatistics, assessing the fragility of research findings is crucial for understanding their clinical significance. This study focuses on the fragility index, unit fragility index, and relative risk index as measures to evaluate ...
Heston TF.
europepmc +2 more sources
The fragility index: how robust are the outcomes of head and neck cancer randomised, controlled trials? [PDF]
J Laryngol Otol, 2023 Background The fragility index represents the minimum number of patients required to convert an outcome from statistically significant to insignificant.
Suresh NV +7 more
europepmc +2 more sources
The Fragility Index of Randomized Controlled Trials for Preterm Neonates [PDF]
Frontiers in Pediatrics, 2022 BackgroundAs a metric to determine the robustness of trial results, the fragility index (FI) is the number indicating how many patients would be required to reverse the significant results.
Huiyi Li +4 more
doaj +2 more sources
The Continuous Fragility Index of Statistically Significant Findings in Randomized Controlled Trials That Compare Interventions for Anterior Shoulder Instability. [PDF]
Am J Sports MedBackground: Evidence-based care relies on robust research. The fragility index (FI) is used to assess the robustness of statistically significant findings in randomized controlled trials (RCTs). While the traditional FI is limited to dichotomous outcomes,
Al-Asadi M +6 more
europepmc +2 more sources
Colorectal Disease, 2023 The aim of this work was to evaluate the robustness of randomized controlled trials (RCTs) on anal fistula management using the news tools of Fragility Index (FI), Reverse Fragility Index (RFI) and their corresponding fragility quotients.
Yolanda Saralegui +2 more
exaly +2 more sources