Results 101 to 110 of about 4,896,431 (278)

"Measuring Macroprudential Risk: Financial Fragility Indexes" [PDF]

With the Great Recession and the regulatory reform that followed, the search for reliable means to capture systemic risk and to detect macrofinancial problems has become a central concern.
Éric Tymoigne
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Monitoring Banking Sector Fragility [PDF]

In the financial crisis literature, it is usually argued that, contrary to the case of currency crises, building a time series index to identify banking crisis episodes is highly difficult, particularly because of the lack of reliable data on banking ...
Aykut Kibritcioglu
core  

Fragility of Observed Associations in Selection of Empirical Antifungal Therapy for Critically Ill Non-Neutropenic Patients [Letter]

Infection and Drug Resistance
Saba ManzoorDaniele Roberto GiacobbeRonald ChowDepartment of Medicine, University of Toronto, Toronto, Ontario, CanadaDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, ItalyClinica Malattie Infettive, Azienda Ospedaliera Metropolitana ...
Manzoor S, Giacobbe DR, Chow R
doaj  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Response to "Fragility of Observed Associations in Selection of Empirical Antifungal Therapy for Critically Ill Non-Neutropenic Patients” [Response to Letter]

Infection and Drug Resistance
Shahad A Albakri,1 Ahmad K Aljabri,2 Emad A Alharbi,2 Buthainah B Alammash,1 Salman A Alabdali,2 Maha F Alahmadi,1 Nawaf T Almutairi,1 Hindi S Alharbi,2 Fahad Alzahrani,3 Faris S Alnezary31Pharmaceutical Care Department, King Fahad Hospital, Ministry of ...
Albakri SA, Aljabri AK, Alharbi EA, Alammash BB, Alabdali SA, Alahmadi MF, Almutairi NT, Alharbi HS, Alzahrani F, Alnezary FS   +9 more
doaj  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Governance and Financial Fragility: Evidence from a Cross-Section of Countries [PDF]

The author explores the role of governance mechanisms as a means of reducing financial fragility. First, he develops a simple theoretical general-equilibrium model in which instability arises due to an agency problem resulting from a conflict of interest
Michael Francis
core  

A correlation among fragility, elastic modulus and temperature rise in shear bands of metallic glasses

Philosophical Magazine Letters
Metallic glasses (MGs) exhibit superior engineering properties such as high strength and good corrosion resistance but often suffer from limited plasticity.
Tejaswini Pulavarthi, Jayanta Das
doaj   +1 more source