Results 81 to 90 of about 4,896,431 (278)
Correlation between fragility and free volume void size at glass transition temperature
AIP Advances, 2022 Despite the tremendous endeavors devoted to exploiting the nature of glass transition, the factors that control the steepness index of viscosity near glass transition, that is, fragility, remain unclear.
Qingli Ma +7 more
doaj +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Frailty index and its role in emergency surgery of acute abdominal diseases in elderly patients
Якутский медицинский журналThe study involved patients over the age of 62 years with acute diseases of the abdominal cavity, who underwent surgical treatment. The patients were divided into two groups based on the Edmonton fragility index.
B. D. Khagverdiev, N. A. Khagverdiev
doaj +1 more source
Advances in Materials Science and Engineering, 2019 Most conventional seismic fragility analyses of RC buildings usually ignore or greatly simplify the soil-structure interaction (SSI), and the maximum interstory drift ratio (MIDR) is often adopted to establish seismic fragility curves.
Panpan Zhai +4 more
doaj +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Fragility, conflict, and migration
, 2023 Fragility, Conflict, and Migration addresses challenges to livelihood, food, and climate security faced by some of the most vulnerable populations worldwide.
Kosec, Katrina; Laderach, Peter; and Ruckstuhl, Sandra +1 more
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source