Results 81 to 90 of about 8,391,091 (301)
Discordance between Prevalent Vertebral Fracture and Vertebral Strength Estimated by the Finite Element Method Based on Quantitative Computed Tomography in Patients with Type 2 Diabetes Mellitus. [PDF]
PLoS ONE, 2015 Bone fragility is increased in patients with type 2 diabetes mellitus (T2DM), but a useful method to estimate bone fragility in T2DM patients is lacking because bone mineral density alone is not sufficient to assess the risk of fracture.
Nobuaki Kiyohara +2 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
BMC Musculoskeletal Disorders, 2010 Background One in four Swedish women suffers a hip fracture yielding high morbidity and mortality. We wanted to revalidate a 4-item clinical risk score and evaluate a portable heel bone mineral density (BMD) technique regarding hip and fragility fracture
Thulesius Hans +4 more
doaj +1 more source
Correlation between fragility and free volume void size at glass transition temperature
AIP Advances, 2022 Despite the tremendous endeavors devoted to exploiting the nature of glass transition, the factors that control the steepness index of viscosity near glass transition, that is, fragility, remain unclear.
Qingli Ma +7 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Advances in Civil Engineering, 2019 Cumulative plastic strain (CPS) damage index is proposed in this study for seismic fragility analysis by integrating the force analogy method into the energy balance equation, and CPS can be defined as the ratio of the demand of plastic dissipation ...
Qiang Wang, Ziyan Wu
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Soil fragility index: Tool and implementation
Ecological IndicatorsThe soil fragility index is a tool to define point of no return of soil recovery. We develop a soil fragility index (dC/dB) based on soil properties (soil organic carbon, bulk density and extractable aluminum) to zone productive and natural ecosystems ...
Felipe Zúñiga +6 more
doaj +1 more source
Advances in Materials Science and Engineering, 2019 Most conventional seismic fragility analyses of RC buildings usually ignore or greatly simplify the soil-structure interaction (SSI), and the maximum interstory drift ratio (MIDR) is often adopted to establish seismic fragility curves.
Panpan Zhai +4 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source