Results 61 to 70 of about 8,391,091 (301)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin +2 more
wiley +1 more source
Redefining Significance: Robustness and Percent Fragility Indices in Biomedical Research
StatsThe p-value has long been the standard for statistical significance in scientific research, but this binary approach often fails to consider the nuances of statistical power and the potential for large sample sizes to show statistical significance ...
Thomas F. Heston
doaj +1 more source
Health Expectations, 2022 Background This paper is a follow‐up study continuing the COVISTRESS network previous research regarding health‐related determinants. Objective The aim was to identify the main consequences of COVID‐19 lockdown on Body Mass Index and Perceived Fragility,
Constanta Urzeala +15 more
doaj +1 more source
JSES International, 2021 Introduction We hypothesized that the modified Fragility Index (mFI), which predicts surgical complications, would be applicable to surgical complications in patients older than 50 years with distal humerus fractures (DHF).
Eliana B. Saltzman +10 more
semanticscholar +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Fragility Index - Perioperative anesthesiology guidelines 2012-2022
, 2023 Introduction: The Fragility Index (FI) and the FI family are statistical tools that measure the robustness of randomized controlled trials (RCT) by examining how many patients would need a different outcome to change the statistical significance of the ...
Margarita Maria Otalora Esteban
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Diabetology & Metabolic SyndromeBackground The triglyceride-glucose (TyG) index, a recognized marker for insulin resistance, holds potential implications for skeletal health. However, its relationship with fragility fractures remains uncertain.
Yuan Lou +4 more
doaj +1 more source