Results 71 to 80 of about 4,896,431 (278)

The fragility index in randomised controlled trials of interventions for aneurysmal subarachnoid haemorrhage: a systematic review

open access: yes, 2021
Background Fragility analysis supplements the p-value and risk of bias assessment in the interpretation of results of randomised controlled trials. In this systematic review we determine the fragility index (FI) and fragility quotient (FQ) of randomized ...
Munby, Henry   +2 more
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

Robustness for prediction of independence in ADL (Barthel Index at T2 ≥ 75) reporting Fragility Index (FI).

open access: yes, 2018
Robustness for prediction of independence in ADL (Barthel Index at T2 ≥ 75) reporting Fragility Index (FI).
Michela Goffredo (4872562)   +7 more
core   +1 more source

Fragility index of randomised controlled trials

open access: yes, 2020
The fragility index is a measure of the robustness of the results of a clinical trial. The index is a number indicating how many participants of a trial need to be changed from 'event' to 'non-event' for the trial to lose statistical significance.
Jasper Kampman
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

open access: yesFEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda   +2 more
wiley   +1 more source

Hip and fragility fracture prediction by 4-item clinical risk score and mobile heel BMD: a women cohort study

open access: yesBMC Musculoskeletal Disorders, 2010
Background One in four Swedish women suffers a hip fracture yielding high morbidity and mortality. We wanted to revalidate a 4-item clinical risk score and evaluate a portable heel bone mineral density (BMD) technique regarding hip and fragility fracture
Thulesius Hans   +4 more
doaj   +1 more source

Discordance between Prevalent Vertebral Fracture and Vertebral Strength Estimated by the Finite Element Method Based on Quantitative Computed Tomography in Patients with Type 2 Diabetes Mellitus. [PDF]

open access: yesPLoS ONE, 2015
Bone fragility is increased in patients with type 2 diabetes mellitus (T2DM), but a useful method to estimate bone fragility in T2DM patients is lacking because bone mineral density alone is not sufficient to assess the risk of fracture.
Nobuaki Kiyohara   +2 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Soil fragility index: Tool and implementation

open access: yesEcological Indicators
The soil fragility index is a tool to define point of no return of soil recovery. We develop a soil fragility index (dC/dB) based on soil properties (soil organic carbon, bulk density and extractable aluminum) to zone productive and natural ecosystems ...
Felipe Zúñiga   +6 more
doaj   +1 more source

Multidimensional Fragility Analysis for a NEES Frame Structure by Integrating a New Energy Damage Index: Cumulative Plastic Strain

open access: yesAdvances in Civil Engineering, 2019
Cumulative plastic strain (CPS) damage index is proposed in this study for seismic fragility analysis by integrating the force analogy method into the energy balance equation, and CPS can be defined as the ratio of the demand of plastic dissipation ...
Qiang Wang, Ziyan Wu
doaj   +1 more source

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