Results 91 to 100 of about 4,896,431 (278)

Multidimensional Seismic Fragility Study of Intake Towers Based on Incremental Dynamic Analysis

Buildings
Assessing the fragility of intake towers using a single damage index does not allow for accurate evaluation of the potential for structural damage under seismic conditions.
Xiaona Li, Yingjie Zhou, Hemin Zhu, Yuchen Li, Haowen An   +4 more
doaj   +1 more source

How States Become Fragile: Relevancy of State Fragility and Climate Change

E3S Web of Conferences, 2018
The objective of this article is to develop a main index that is capable of determining a state, s fragility and simultaneously measuring the impact of climate change.
Zhang Sirui, Chen Jiebin, Wu Hao-Ning, Ye Shiqi   +3 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Randomized controlled trial outcomes for nonoperative management of lateral epicondylitis of the elbow are statistically fragile: a systematic review

JSES Reviews, Reports, and Techniques
Background: Nonoperative management remains the first line treatment for lateral epicondylitis of the elbow. In this study, we evaluated the reliability of outcomes reported in randomized controlled trials (RCTs) focusing on nonoperative therapies using ...
Reanna Shah, BS, Alexander Yu, BS, Mary Grace Kelley, MS, Avanish Yendluri, BS, Dennis Bienstock, MD, Katrina Nietsch, MS, Michael N. Megafu, MPH, Xinning Li, MD, John D. Kelly, IV, MD, Robert L. Parisien, MD   +9 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The Fragile Definition of State Fragility [PDF]

We investigates the link between fragility and economic development in sub-Saharan Africa over a yearly panel including 28 countries for the 1999-2004 period.
Graziella Bertocchi, Andrea Guerzoni
core  

A pragmatic evaluation of outcome fragility in randomized clinical trials comparing open microdiscectomy and endoscopic-assisted discectomy: A meta-analysis

North American Spine Society Journal
: Background: RCTs comparing endoscopic-assisted and open lumbar discectomy frequently show significant findings despite few events and inconsistent follow-up, undermining confidence in their robustness.
Michael D. Brown, MD, Alqasim Elnaggar, BA, Obed Barkus, MD, Doyle Ford, BS, Andy T. Ton, MD, David Abdelnour, BA, Ali Mehaidli, MD, Kevin Taliaferro, MD   +7 more
doaj   +1 more source

Revealing the role of molecular rigidity on the fragility evolution of glass-forming liquids

Nature Communications, 2016
The fragility describes the degree of slowdown in material dynamics as approaching glass transition temperature, but its molecular origin remains unclear.
C. Yildirim, J.-Y. Raty, M. Micoulaut
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source