Results 131 to 140 of about 8,391,091 (301)
Bank Concentration and Fragility: Impact and Mechanics [PDF]
Public policy debates and theoretical disputes motivate this paper%u2019s examination of (i) the relationship between bank concentration and banking system fragility and (ii) the mechanisms underlying this relationship.
Thorsten Beck +2 more
core
Seismic Fragility Analysis of Bridge System Based on Fuzzy Failure Criteria
Advances in Civil Engineering, 2019 In the traditional bridge seismic fragility analysis, the criterion for judging the structural damage state is clear. That is to say, when the damage index exceeds a specific value, the structure is judged to enter the new damage state.
Leping Ren +3 more
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Fragility of the Fragility Index: When Calculation Becomes Impossible
The Fragility Index (FI) has become a widely cited measure of statistical robustness in clinical trials, yet its computation often fails under Fisher’s exact test constraints. This paper systematically demonstrates that the FI is mathematically unattainable across a broad range of realistic clinical scenarios—including rare events, balanced small ...
openaire +2 more sources
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Market Evaluations of Banking Fragility in Japan: Japan Premium, Stock Prices, and Credit Derivatives [PDF]
This paper investigates movements of market indicators of banking fragility, namely, Japan premium, stock prices, and credit derivative spreads of Japanese banks.
Takatoshi Ito, Kimie Harada
core
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Market Indicators, Bank Fragility, and Indirect Market Discipline [PDF]
We examine whether two commonly used indicators of bank fragility, the subordinated debt spread and KMV’s distance to default, yield signals in line with supervisors’ interests.
Giuseppe Vulpes +2 more
core
Contemporary Clinical Trials CommunicationsIntroduction: Frequentist methods of statistical inference in randomized controlled trials (RCTs) may inadequately reflect clinical importance of results.
Tonya M. Esterhuizen +7 more
doaj +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source