Results 151 to 160 of about 8,391,091 (301)

Assessing fragility of statistically significant findings from randomized controlled trials assessing pharmacological therapies for opioid use disorders: a systematic review

Trials
Background The fragility index is a statistical measure of the robustness or “stability” of a statistically significant result. It has been adapted to assess the robustness of statistically significant outcomes from randomized controlled trials.
Leen Naji, Brittany Dennis, Myanca Rodrigues, Monica Bawor, Alannah Hillmer, Caroul Chawar, Eve Deck, Andrew Worster, James Paul, Lehana Thabane, Zainab Samaan   +10 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Financial Fragility with Rational and Irrational Exuberance [PDF]

This article formalizes investor rationality and irrationality, exuberance and apprehension, to consider the implications of belief formation for the fragility of an economy¦s financial structure.
Stacey L. Schreft, Roger Lagunoff
core  

Fragility index of meta-analyses in paediatric surgery [PDF]

Pediatric Surgery International, 2021
Priyam Saikia, Bandana Thakuria
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Independent and synergistic associations of cumulative body roundness index and its variability with fragility fracture risk

Lipids in Health and Disease
Background The body roundness index (BRI) is a more comprehensive anthropometric measure than the body mass index (BMI) because it reflects the distribution of visceral fat more accurately.
Zhou Yang, Lu Guo, Nan Zhang, Wenchao Yao, Yimin Liu, Wenqi Xu, Xinhao Fan, Xiaoli Hou, Jingyao Wang, Shuohua Chen, Jingyuan Gao, Lei Xing, Shouling Wu, Faming Tian   +13 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Dundee Discussion Papers in Economics 185:Extracting leading indicators of bank fragility from market prices: Estonia focus [PDF]

, 2005
Banking reform has proved to be one of the most problematic elements of economic transition in central and eastern Europe. Therefore the paper considers the development of the Estonian banking sector and derives individual banks´ fragility scores during ...
Mannasoo, Kadri, Chen, Yu-Fu, Funke, Michael   +2 more
core  

Spatial Differentiation Character of Fragile Ecology and Fragility Analysis in Yulin City

Shuitu baochi yanjiu, 2010
The fragility of ecological environment results from natural factor and human factor. The spatial differentiation character of climate,population,per capita water resources and economy are analyzed quantitatively by indicators and methods including ...
WANG Hong-wei, ZHANG Xin, QIU Jun-nan
doaj  

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source