Results 141 to 150 of about 4,896,431 (278)

Assessing fragility of statistically significant findings from randomized controlled trials assessing pharmacological therapies for opioid use disorders: a systematic review

Trials
Background The fragility index is a statistical measure of the robustness or “stability” of a statistically significant result. It has been adapted to assess the robustness of statistically significant outcomes from randomized controlled trials.
Leen Naji, Brittany Dennis, Myanca Rodrigues, Monica Bawor, Alannah Hillmer, Caroul Chawar, Eve Deck, Andrew Worster, James Paul, Lehana Thabane, Zainab Samaan   +10 more
doaj   +1 more source

Diffuse MRI Edema Predicts Relapse in Cerebral Amyloid Angiopathy–Related Inflammation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify MRI predictors of relapse and quantify relapse and mortality risk in cerebral amyloid angiopathy–related inflammation (CAA‐RI). A secondary objective was to assess the association between mycophenolate mofetil use and relapse risk. Methods We performed a retrospective cohort study of 36 patients with CAA‐RI treated at the
G. Abbas Kharal, Gowtham Yerneni, Kim J. Griffin, Nicolas Thompson, Ken Uchino, Irene Katzan, Dolora Wisco, Abeer Farrag, Jayashree Sundarajan, Andrew Russman, M. Shazam Hussain   +10 more
wiley   +1 more source

The Global Fragility Index: A Path-Independent Measure of Statistical Fragility

Background: The fragility index quantifies statistical fragility by counting the number of outcome changes needed to reverse statistical significance. However, it depends on arbitrary event definitions and follows specific toggle rules that may not find the actual minimum perturbation. We introduce the global fragility index, a path-independent measure
openaire   +2 more sources

Association Between Neurofilament Light Chain and Real‐World Ambulatory Function in Progressive MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurofilament light chain (NfL) is a biomarker of neuroaxonal injury in multiple sclerosis (MS), yet associations with functional outcomes remain unclear. Longitudinal associations between serum NfL (sNfL) and daily step count (STEPS) from wearable devices were assessed in a large international progressive MS cohort.
Gabby B. Joseph, Megan McCune, Riley Bove, Ahmed Abdelhak, Bruce A. C. Cree, Valerie J. Block   +5 more
wiley   +1 more source

Independent and synergistic associations of cumulative body roundness index and its variability with fragility fracture risk

Lipids in Health and Disease
Background The body roundness index (BRI) is a more comprehensive anthropometric measure than the body mass index (BMI) because it reflects the distribution of visceral fat more accurately.
Zhou Yang, Lu Guo, Nan Zhang, Wenchao Yao, Yimin Liu, Wenqi Xu, Xinhao Fan, Xiaoli Hou, Jingyao Wang, Shuohua Chen, Jingyuan Gao, Lei Xing, Shouling Wu, Faming Tian   +13 more
doaj   +1 more source

Juvenile Huntington Disease With Cerebellar‐Predominant Atrophy Identified by Genome Sequencing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Juvenile Huntington disease accounts for a small fraction of Huntington disease cases and is driven by the largest trinucleotide repeat expansions. We describe a 6‐year‐old boy with progressive global regression, generalized dystonia, and epilepsy, in whom serial imaging showed striking cerebellar‐predominant atrophy with an initially normal ...
Enrique Gonzalez Saez‐Diez, Amy Tam, Siofra Carty, Monica Ferrer Socorro, Kathryn Yang, Darius Ebrahimi‐Fakhari   +5 more
wiley   +1 more source

A Simple Index of Banking Fragility: Application to Indian Data [PDF]

Using data on Indian banks for 1997-2007, the paper develops an index of banking fragility and subsequently examines the factors affecting the index. Based on the statistical properties of the index, we classify banks as exhibiting high, moderate and low
Saibal, Ghosh
core  

Spatial Differentiation Character of Fragile Ecology and Fragility Analysis in Yulin City

Shuitu baochi yanjiu, 2010
The fragility of ecological environment results from natural factor and human factor. The spatial differentiation character of climate,population,per capita water resources and economy are analyzed quantitatively by indicators and methods including ...
WANG Hong-wei, ZHANG Xin, QIU Jun-nan
doaj  

Anorectal Dysfunction in Systemic Sclerosis: Clinical Phenotypes and Functional Patterns

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize specific physiologic defects in anorectal dysfunction in systemic sclerosis (SSc) using anorectal manometry (ARM), evaluate associations with gastrointestinal (GI) and extraintestinal clinical phenotypes, and explore potential serologic markers for risk stratification.
Timothy Kaniecki, Alireza Amindarolzarbi, Tsion Abdi, John Clarke, Michael Hughes, Ami A. Shah, Zsuzsanna H. McMahan   +6 more
wiley   +1 more source

Financial Fragility and Economic Fluctuations: Numerical Simulations and Policy Implications [PDF]

This paper proposes a simple prototype model that describes the complex dynamics of a sophisticated monetary economy. The interaction between the current and intertemporal financial constraints of economic units brings about irregular fluctuations at the
Alessandro Vercelli, Serena Sordi
core