Results 101 to 110 of about 4,409,486 (250)

Expression and secretion of Fcpro chimera.

, 2013
A) Schematic representation of Fc and Fcpro constructs. SP: signal peptide. Prosegment: human PCSK9 aa 31 to 152. B) HEK293 cells transiently transfected with cDNAs encoding either pIR: control empty pIRES vector; Pro: PCSK9 prosegment; Fc: human IgG1 ...
Yascara Grisel Luna Saavedra (444344), Nabil G. Seidah (148050), Jianbing Zhang (109867)   +2 more
core   +1 more source

Resolving and Controlling Silicoaluminophosphate Zeolite Intergrowths and Mixtures

Advanced Science, EarlyView.
Low‐dose electron microscopy enables atomic‐resolution imaging of beam‐sensitive SAPO‐34/18 intergrowths, revealing their stacking sequences and spatial distributions under controlled Si content and SDA ratio. This work establishes a methodology linking controllable synthesis with atomic‐resolution microscopy to investigate structure–property ...
Yuxin Ke, Jiale Feng, Lei Wang, Xiao Chen, Mengmeng Ma, Jiabin Cui, Juan Diwu, Yuman Liu, Fei Wei, Boyuan Shen, Bin Song   +10 more
wiley   +1 more source

Identification of engineered IMGT Fc variants in IMGT/mAb-DB, a database of therapeutic antibodies and fusion proteins

mAbs
Monoclonal antibodies (mAbs) and fusion proteins for immune applications (FPIA) play a crucial role in treating autoimmune diseases and cancers by targeting cell-surface proteins and triggering multiple immune mechanisms.
Taciana Manso, Gaoussou Sanou, Christos Nousias, Imene Maalem, François Boutin, Véronique Giudicelli, Patrice Duroux, Marie-Paule Lefranc, Sofia Kossida   +8 more
doaj   +1 more source

An antibody fragment-decorated liposomal conjugate targets Philadelphia-like acute lymphoblastic leukemia [PDF]

Philadelphia-like acute lymphoblastic leukemia (Ph-like ALL) is an aggressive B-ALL malignancy associated with high rates of relapse and inferior survival rate.
Schofield, P, Lock, RB ; https://orcid.org/, Mohamed, SMA ; https://orcid.org/, Moles, E, Christ, D ; https://orcid.org/, Friedrich, KH, Kavallaris, M ; https://orcid.org/, McCalmont, H, Bayat, N ; https://orcid.org/   +8 more
core   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

The fc fragment of IgMs binds C1q to activate the first step of the classical complement pathway, while inhibiting complement‐dependent cytotoxicity

International audienceSoluble IgMs, among the most potent activators of the classical pathway, are key mediators of complement‐dependent cytotoxicity, which render them as promising drug candidates for the development of alternative drugs in treating ...
Pinto, Andrea, Ling, Wai Li, Chouquet, Anne, Kunert, Renate, Rossi, Véronique, Reiser, Jean‐baptiste, Bally, Isabelle, Thielens, Nicole, Dumestre-Pérard, Chantal, Gaboriaud, Christine, Reiser, Jean\u2010Baptiste, Dumestre\u2010P\ue9rard, Chantal, Thielens, Nicole M., Rossi, V\ue9ronique, Pinto, Andrea J.   +14 more
core   +1 more source

Robust Photocatalytic Hydrogen Evolution Over a Conjugated Metal‐Organic Framework Heterojunction

Advanced Science, EarlyView.
We report a conjugated coordination polymer, Cd‐TMT (TMT = 1,3,5‐trimercaptotriazine), featuring an intrinsic molecular‐level charge transport network. The conjugated TMT ligands facilitate strong intra‐ligand charge transfer, while their ordered π‐π stacking along the [111] direction establishes a continuous pathway for directional electron migration,
Chunzhe Wang, Yufei Shan, Ruobing Chu, Lingzhi Yang, Zhanning Liu, Xiaoli Zhang, Jian Tian   +6 more
wiley   +1 more source

Anchor Engineering of Hole‐Selective Enamine‐Based Self‐Assembling Monolayers for Perovskite Solar Cells

Advanced Science, EarlyView.
This work presents novel enamine‐based self‐assembling monolayers with engineered anchoring groups as hole‐selective contacts for inverted perovskite solar cells. The conjugated molecular design suppresses interfacial defects, optimizes charge extraction, and prevents aggregation.
Deimante Krisiune, Yuxuan Yang, Yongde Xu, Hao Tian, Chuanxiao Xiao, Jianxing Xia, Mahan Saberi Zafarghandi, Ali Keshavarz Mohammadian, Negar Ashari Astani, Kasparas Rakstys, Yi Zhang, Vytautas Getautis   +11 more
wiley   +1 more source

Alignment of 310 bp. mtDNA control region fragment of M. schreibersii

, 2015
Alignment of 310 bp.
Jérôme Goudet (169498), Palmeirim, Jorge, Ludovic Dutoit (3199467), Clément, Laura, Pavlinić, Igor, Jorge Palmeirim (3289353), Witsenburg, Fardo, Scaravelli, Dino, Christe, Philippe, Dutoit, Ludovic, Fardo Witsenburg (3257670), Martin Ševčík (3289359), Salamin, Nicolas, Goudet, Jérôme, Nicolas Salamin (2923683), Ševčík, Martin, Philippe Christe (326887), Laura Clément (3289365), Adrià López-Baucells (3289356), López-Baucells, Adrià, Igor Pavlinić (3289362), Dino Scaravelli (650423)   +21 more
core   +1 more source

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source