Results 101 to 110 of about 4,204,588 (241)
Fragment-Based Design of Mycobacterium Tuberculosis InhA Inhibitors
, 2019 Tuberculosis (TB) remains a leading cause of mortality amongst infectious diseases worldwide. InhA, an enoyl ACP-reductase, has been the focus of numerous drug discovery efforts as this is the target of the first line pro-drug isoniazid.
Vitor Mendes (6702665) +9 more
core +1 more source
Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer
Advanced Science, EarlyView.The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu +13 more
wiley +1 more source
Fragment-based screening by protein crystallography: successes and pitfalls
, 2012 Fragment-based drug discovery (FBDD) concerns the screening of low-molecular weight compounds against macromolecular targets of clinical relevance. These compounds act as starting points for the development of drugs.
Aaron Oakley (19584748) +2 more
core +1 more source
Advances and Perspectives in Graphene‐Based Quantum Dots Enabled Neuromorphic Devices
Advanced Science, EarlyView.Graphene‐based QDs are zero‐dimensional carbon nanomaterials with pronounced quantum confinement and tunable electronic structures. Herein, we summarize their synthesis strategies and functionalization methods, and highlight their functional roles and operating mechanisms in devices, as well as recent advances in neuromorphic electronics. We anticipate
Yulin Zhen +9 more
wiley +1 more source
AntibodiesBackground: Tetanus toxin, produced by Clostridium tetani, is the second deadliest known toxin. Antibodies capable of neutralizing tetanus toxin (TeNT) are vital for preventing and treating tetanus disease.
Yating Li +11 more
doaj +1 more source
Fragment-based screening with natural products for novel anti-parasitic disease drug discovery
, 2019 Introduction: Fragment-based drug discovery can identify relatively simple compounds with low binding affinity due to fewer binding interactions with protein targets.
Ronald J. Quinn (134169) +1 more
core +1 more source
Advanced Science, EarlyView.Sinapic acid, a bio‐derived phytophenol, serves as a multifunctional additive for methylammonium (MA)‐free Sn─Pb perovskites, coordinating with Sn2+/Pb2+ to regulate crystallization and mitigate defects. Its electron‐rich groups suppress Sn oxidation and passivate deep traps, improving band alignment and reducing VOC losses. Resulting devices achieve a
Seojun Lee +12 more
wiley +1 more source
Local Immune Activation and Age Impact on Humoral Immunity in Mice, with a Focus on IgG Sialylation
VaccinesAge alters the host’s susceptibility to immune induction. Humoral immunity with circulating antibodies, particularly immunoglobulin G (IgG), plays an essential role in immune response.
Priti Gupta +7 more
doaj +1 more source
, 2008 The cover and size distributions of surface rock fragment in hillslopes were investigated by using digital photographing and treating technique in a small catchment in wind-water erosion crisscross region of the Loess Plateau.
Zhu, YJ (Zhu YuanJun)1,2 +2 more
core
LOW-TEMPERATURE, LOW-DIELECTRIC, CRYSTALLIZABLE GLASS COMPOSITE
, 2011 [[abstract]]A low k crystallizable glass composite containing borosilicate glass and cordierite glass has been developed. Crystallization and densification of cordierite glass is enhanced with borosilicate glass present.
JEAN JH;LIN SC;CHANG CR
core +1 more source