Results 221 to 230 of about 122,949 (273)

A novel variant of NOTCH2 causes skeletal fragility. [PDF]

Bone
Canalis E, Yu J, Denker E, Schilling L, Deymier A, Hao B, Carpenter T.   +6 more
europepmc   +1 more source

Ion–Dipole Interaction‐Driven Assembly of Silicate Cages

Aggregate, EarlyView.
On the basis of ion–dipole interactions, silicate cages containing R[SiO4]− units can directionally bind K+ ions, thereby constructing frameworks with specific topologies. This strategy effectively addresses the challenges of strong solvation and non‐directional binding.
Yutao Guan, Hongqing Li, Ju Yang, Dingyue Hu, Saisai Yu, Ming Liu   +5 more
wiley   +1 more source

Recent Advances in Enhancing Functionalization of Atomically Precise Copper Hydride Clusters

Aggregate, EarlyView.
In this review, advances in the methodology for the preparation and understanding of atomically precise copper hydride clusters are comprehensively summarized. Whereafter, the methods of structures determination in copper hydride clusters are discussed in detail.
Miao‐Miao Zhang, Ting‐Ting Liang, Chong Zhang, Huanhuan Zhang, Yu‐Fan Li, Yuanyuan Li, Shuang‐Quan Zang   +6 more
wiley   +1 more source

Current landscape of T-cell engagers in early-phase clinical development in solid cancers. [PDF]

Front Immunol
Spinazzola A, Iannantuono GM, Gulley JL, Giudice E, Filetti M, Sganga S, Bianco FL, Floudas CS, Daniele G.   +8 more
europepmc   +1 more source

Designing Memristive Materials for Artificial Dynamic Intelligence

Advanced Intelligent Discovery, EarlyView.
Key characteristics required of memristors for realizing next‐generation computing, along with modeling approaches employed to analyze their underlying mechanisms. These modeling techniques span from the atomic scale to the array scale and cover temporal scales ranging from picoseconds to microseconds. Hardware architectures inspired by neural networks
Youngmin Kim, Ho Won Jang
wiley   +1 more source

Ruthenium Complexes in Protein Science: Heading a New Generation of Therapeutic and Analytical Tools

Angewandte Chemie, EarlyView.
This review presents the latest advances in the development of ruthenium complexes within the field of protein science, highlighting their potential applications in biomedical and bioanalytical fields. Abstract Ruthenium complexes are distinguished by their versatile coordination chemistry, redox behaviors and photochemical properties. In recent years,
Liyan Zhang, Yun Chen, Sylvestre Bonnet
wiley   +2 more sources

Structure and Spectroscopic Characterisation of Phenanthroline‐Based Iodobismuthate(III) Complexes Utilised for Raw Acoustic Signal Classification

Advanced Intelligent Discovery, EarlyView.
Memristors based on trimethylsulfonium (phenanthroline)tetraiodobismuthate have been utilised as a nonlinear node in a delayed feedback reservoir. This system allowed an efficient classification of acoustic signals, namely differentiation of vocalisation of the brushtail possum (Trichosurus vulpecula).
Ewelina Cechosz, Gisya Abdi, Andrzej Sławek, Marlena Gryl, Konrad Szaciłowski   +4 more
wiley   +1 more source

From Pharmacophore to Warhead: NAD+‐Targeting Triazoles as Mechanism‐Based Sirtuin Inhibitors

Angewandte Chemie, EarlyView.
We report “Sirtuin Trapping Ligands” (SirTraps), mechanism‐based 1,2,3‐triazole inhibitors that hijack sirtuin (SIRT) catalysis to form covalent triazolium– or triazole–ADP‐ribose (ADPR) adducts from NAD+. These trapped intermediates stall the enzyme in an inactive state, providing a biocompatible alternative to thiocarbonyl inhibitors and a blueprint ...
Florian Friedrich, Marat Meleshin, Niklas Papenkordt, Lena Gaitzsch, Isabel Prucker, Marco Borso, Jan Ruprecht, Christopher Vorreiter, Sabrina Rast, Lin Zhang, Matthias Schiedel, Wolfgang Sippl, Axel Imhof, Henning J. Jessen, Oliver Einsle, Mike Schutkowski, Manfred Jung   +16 more
wiley   +2 more sources

Immunoglobulin: unraveling its complex web in aging. [PDF]

Front Immunol
Gu Q, Wang Y, Zhu C, Zhou X, Ni L, Zhao H, Yang H, Shi Q.   +7 more
europepmc   +1 more source

Antibacterial Applications of Black and Violet Phosphorus‐Based Biomaterials

Advanced NanoBiomed Research, EarlyView.
Black and violet phosphorus‐based biomaterials exhibit broad‐spectrum antibacterial efficacy in various infections, including bone, skin, ocular, dental, lung, and sepsis cases. Their antibacterial mechanisms include physical disruption, light‐driven effects, targeted drug delivery, and enhanced composite strategies.
Zhuo Dai, Yu Zhang, Xiaoye Li, Ao He, Qiang Li, Weijun Xiu, Yongbin Mou, Heng Dong, Meng Ding   +8 more
wiley   +1 more source