Results 231 to 240 of about 122,949 (273)

Human Proteoglycan Linkage Region Glycosyltransferases are Dimeric and Show Unexpected Specificities

Angewandte Chemie, EarlyView.
Non‐canonical glycopeptides of the proteoglycan linkage region are accessible by the enzymes B3GalT6 and GlcAT‐1 confirming a recently discovered rescue mode in glycosaminoglycan (GAG) biosynthesis. The crystal structure of B3GalT6 revealed a covalent dimer linked by a disulfide. Abstract We selected the N,O‐glycosylated proteoglycan bikunin as a model
Sascha Weidler, Ole Bundgaard, Markus Hessefort, Marisa Rädisch, Christopher Günther Franz Graf, Kevin Lam, Vanessa J. Neubauer, Johanna Eisenreich, Leonhard Köhler, Kelley W. Moremen, Catharina Steentoft, Henrik Clausen, Teng‐Yi Huang, Shang‐Cheng Hung, Clemens Steegborn, Michael Weyand, Carlo Unverzagt   +16 more
wiley   +2 more sources

Monoclonal antibody biosimilars for cancer treatment. [PDF]

iScience
Broer LN, Knapen DG, de Groot DA, Mol PGM, Kosterink JGW, de Vries EGE, Lub-de Hooge MN.   +6 more
europepmc   +1 more source

The dual role of IgG4 in immunity: bridging pathophysiology and therapeutic applications. [PDF]

Gut
Piseddu I, Mayerle J, Mahajan UM, Boehmer DFR.   +3 more
europepmc   +1 more source

Production of site-specific antibody conjugates using metabolic glycoengineering and novel Fc glycovariants. [PDF]

J Biol Chem
Bernstein ZJ, Gierke TR, Dammen-Brower K, Tzeng SY, Zhu S, Chen SS, Wilson DS, Green JJ, Yarema KJ, Spangler JB.   +9 more
europepmc   +1 more source

Latest Findings in Immunoglobulin Y Technologies and Applications. [PDF]

Int J Mol Sci
Capotă R, Ciaușu-Sliwa D, Bostănaru-Iliescu AC, Năstasă V, Mareș M.   +4 more
europepmc   +1 more source

Design, Synthesis, and Structural Evolution of Pseudo‐Natural Product IDO1 Inhibitors and Degraders

Angewandte Chemie, EarlyView.
The combination of bicyclic monoterpene‐ and pyrrolidine‐alkaloid fragments yields novel pseudo‐natural products. Biological characterization revealed that these iDegs are inhibitors and degraders of indoleamine‐2,3‐dioxygenase. Abstract Terpenoid alkaloids are derived from the fusion of structurally diverse terpenoid‐ and alkaloid moieties.
Xiu‐Fen Cheng, Belén Lucas, Philipp Lampe, Stefano Ugel, Suyuan Chen, Anke Unger, Matthias Bischoff, Soheila Rezaei Adariani, Kesava Reddy Naredla, Kamal Kumar, Annika Schmidt, Carsten Strohmann, Petra Janning, Raphael Gasper, María Lucas, Malte Gersch, Sonja Sievers, Vincenzo Bronte, Slava Ziegler, Herbert Waldmann   +19 more
wiley   +1 more source

Gene Therapy for Wet Age-Related Macular Degeneration. [PDF]

Bioengineering (Basel)
Barthelemy N, Sridhar J, Sengillo JD.
europepmc   +1 more source

Selective, Oxygen‐Tunable, and Metal‐Free Functionalization of Polyethylene Through Dual‐Mode Nitrosation and Carbonylation

Angewandte Chemie, EarlyView.
A metal‐free nitrosation process enables direct C–H functionalization of polyethylene (PE) with high selectivity, producing either oxime‐ or carbonyl‐functionalized polymers. Using t‐BuONO under visible light or thermal conditions, the process operates in both lab‐scale and industrial settings.
Lucile Cluzeau, Frédéric Robert, Dario M. Bassani, Yannick Landais, Daniel Taton   +4 more
wiley   +1 more source

Analytical Characterization for Similarity Assessment Between an Aflibercept Biosimilar SB15 and Reference Product (Eylea^®). [PDF]

Ophthalmol Ther
Lee H, Huh J, Kim D, Lee S, Lee J, Lee J, Kim BC, Song J.   +7 more
europepmc   +1 more source

Time‐Resolved SAXS Studies During the Synthesis of Hydrolytically Degradable Poly(ε‐caprolactone)‐Poly(N,N′‐dimethylacrylamide) Diblock Copolymer Nanoparticles in Aqueous Media

Angewandte Chemie, EarlyView.
Synthesis of hydrolytically degradable poly(N,N′‐dimethylacrylamide)‐poly(ɛ‐caprolactone) nanoparticles via reverse sequence polymerization‐induced self‐assembly (PISA) at 80 °C is studied by time‐resolved small‐angle X‐ray scattering (SAXS). This technique reveals the formation of molten poly(ɛ‐caprolactone) (PCL) droplets prior to water addition, a ...
Matthew A. H. Farmer, Oleksandr O. Mykhaylyk, Olga Shebanova, Osama M. Musa, Steven P. Armes   +4 more
wiley   +1 more source