Results 251 to 260 of about 122,949 (273)

A Method to Detect the Binding of Hyper-Glycosylated Fragment Crystallizable (Fc) Region of Human IgG1 to Glycan Receptors

Methods in molecular biology, 2018
Patricia A. Blundell, Richard J. Pleass
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3.5 Elevated Levels of Both Membrane-Bound and Soluble Forms of a Receptor Specific for the Fragment Crystallizable Region of Immunoglobulin M in Patients with CLL

, 2011
Fu Jun Li, Yoshiki Kubagawa, Matthew K. McCollum, Landon Wilson, Tomoko Motohashi, Luigi F. Bertoli, James C. Barton, Stephen Barnes, Randall S. Davis, Hiromi Kubagawa   +9 more
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Generation and Biological Evaluation of Fc Antigen Binding Fragment-Drug Conjugates as a Novel Antibody-Based Format for Targeted Drug Delivery.

Bioconjugate chemistry, 2021
Fragment crystallizable (Fc) antigen binding fragments (Fcabs) represent a novel antibody format comprising a homodimeric Fc region with an engineered antigen binding site.
S. Jäger, T. Wagner, Nicolas Rasche, H. Kolmar, S. Hecht, C. Schröter   +5 more
semanticscholar   +1 more source

Abstract 516: N-glycan moiety of IgG-Fc region is a prognostic biomarker for advancednon-small cell lung cancertreated with immune checkpoint inhibitors

Cancer Research, 2022
Background: Although it has been known that N-glycan moiety in immunoglobulin G (IgG) fragment crystallizable (Fc) region, which affects antigen dependent cellular cytotoxicity (ADCC) activity is different between healthy individuals and cancer ...
J. Oyanagi, Y. Koh, Y. Akiyama, Atsushi Morimoto, Koichi Sato, S. Teraoka, D. Fujimoto, N. Tokudome, A. Hayata, Y. Ozawa, H. Akamatsu, M. Nakanishi, H. Ueda, Nobuyuki Yamamoto   +13 more
semanticscholar   +1 more source

Efficient inhibition of SARS-CoV-2 strains by a novel ACE2-IgG4-Fc fusion protein with a stabilized hinge region

bioRxiv, 2020
The novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) enters its host cells after binding to the angiotensin-converting enzyme 2 (ACE2) via its spike glycoprotein.
Hristo L. Svilenov, Julia Sacherl, A. Reiter, Lisa S. Wolff, Chongguang Chen, Marcel Stern, F. Wachs, Nicole Simonavicius, S. Pippig, F. Wolschin, J. Buchner, C. Brockmeyer, U. Protzer   +12 more
semanticscholar   +1 more source

Oriented Antibody-Assembled Metal-Organic Frameworks for Persistent Wearable Sweat Cortisol Detection.

Analytical Chemistry, 2023
The level of cortisol can reflect people's psychological stress, help diagnose adrenal gland diseases, and is also related to several mental diseases. In this study, we developed a cortisol monoclonal antibody-oriented approach to modify an immunosensor ...
Guang Tian, Zhongzeng Zhou, Mengmeng Li, Xiangnan Li, Tailin Xu, Xueji Zhang   +5 more
semanticscholar   +1 more source

Cellular effects and orientation of immobilized immunoglobulin are correlated to the charge-mediated influence of the antibody variable region.

Biointerphases
Ligand binding to a cell receptor often insufficiently triggers cellular immune responses. Receptor clustering through cross-linking occurs when a ligand binds to two or more receptors, amplifying cellular responses.
Hsi-Ju Wei, Jun Zhang, J. Barbon, Nancy Crosbie, Eric Dominguez   +4 more
semanticscholar   +1 more source

A Comprehensive Review on the Pharmacokinetics and Drug−Drug Interactions of Approved GLP-1 Receptor Agonists and a Dual GLP-1/GIP Receptor Agonist

Drug Design, Development and Therapy
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are peptide-derived analogs that were initially investigated to treat type 2 diabetes. Recently, a drug targeting the receptors of both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP ...
Jee Sun Min, Seongjun Jo, Sangyoung Lee, Duk Yeon Kim, Da Hyun Kim, Chae Bin Lee, Soo Kyung Bae   +6 more
semanticscholar   +1 more source

Coordinating interleukin-2 encoding circRNA with immunomodulatory lipid nanoparticles to potentiate cancer immunotherapy

Science Advances
Interleukin-2 (IL-2) is a cytokine vital for CD8+ T cell activation and proliferation, holding great potential for cancer immunotherapy. Nevertheless, inherent shortcomings of short half-life, activation of regulatory T (Treg) cells, and systemic ...
Kai Yang, Bing Bai, Xiaomei Li, Wei Rou, Cheng Huang, Meixin Lu, Xueyan Zhang, Chunbo Dong, Shaolong Qi, Zhida Liu, Guocan Yu   +10 more
semanticscholar   +1 more source

Broadly neutralizing antibodies for HIV prevention: a comprehensive review and future perspectives

Clinical Microbiology Reviews
SUMMARY The human immunodeficiency virus (HIV) epidemic remains a formidable global health concern, with 39 million people living with the virus and 1.3 million new infections reported in 2022.
S. Mahomed
semanticscholar   +1 more source