Results 21 to 30 of about 4,204,588 (241)

Next generation Fc scaffold for multispecific antibodies

iScience, 2021
Summary: Bispecific antibodies (Bispecifics) demonstrate exceptional clinical potential to address some of the most complex diseases. However, Bispecific production in a single cell often requires the correct pairing of multiple polypeptide chains for ...
Bram Estes, Athena Sudom, Danyang Gong, Douglas A. Whittington, Vivian Li, Christopher Mohr, Danqing Li, Timothy P. Riley, Stone D.-H. Shi, Jun Zhang, Fernando Garces, Zhulun Wang   +11 more
doaj   +1 more source

Efgartigimod, an FcRn antagonist, as a potential treatment for post COVID-19 syndrome

Acta Materia Medica, 2023
A significant proportion of patients who survive coronavirus disease of 2019 (COVID-19) develop a constellation of life-altering symptoms that persist long after the initial infection has resolved.
Sandra E. Reznik, Amit K. Tiwari, Charles R. Ashby   +2 more
doaj   +1 more source

Certolizumab pegol in severe hidradenitis suppurativa in pregnancy: A case report. [PDF]

SAGE Open Med Case Rep
Hidradenitis suppurativa is a chronic inflammatory disease of the skin with a suppurative-cicatricial outcome affecting the infundibular component of the pilo-sebaceous unit.
Gisondi P, Montalto E, Curic T, Danese E, Bellinato F, Girolomoni G.   +5 more
europepmc   +2 more sources

Fragment-Based Approaches to Identify RNA Binders

, 2023
Although fragment-based drug discovery (FBDD) has been successfully implemented and well-explored for protein targets, its feasibility for RNA targets is emerging.
Blessy M. Suresh, Blessy M. Suresh (14047380), Matthew D. Disney (1316157), Amirhossein Taghavi, Matthew D. Disney, Jessica L. Childs-Disney, Amirhossein Taghavi (11597401), Jessica L. Childs-Disney (1316160)   +7 more
core   +1 more source

Fc-Linked IgG N-Glycosylation in FcγR Knock-Out Mice

Frontiers in Cell and Developmental Biology, 2020
Immunoglobulin G (IgG) is the most abundant immunoglobulin isotype in the blood and is involved in the pathogenesis and progression of various diseases.
Olga O. Zaytseva, Michaela Seeling, Jasminka Krištić, Gordan Lauc, Gordan Lauc, Marija Pezer, Falk Nimmerjahn   +6 more
doaj   +1 more source

Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics

mAbs, 2021
Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the ...
Kathryn H. Ching, Kimberley Berg, Kevin Reynolds, Darlene Pedersen, Alba Macias, Yasmina N. Abdiche, William D. Harriman, Philip A. Leighton   +7 more
doaj   +1 more source

Advances in therapeutic Fc engineering - modulation of IgG associated effector functions and serum half-life

Frontiers in Immunology, 2016
Today monoclonal immunoglobulin gamma (IgG) antibodies have become a major option in cancer therapy especially for the patients with advanced or metastatic cancers.
Abhishek Saxena, Donghui Wu
doaj   +1 more source

Cloning, expression and characterisation of antigen-specific recombinant bat immunoglobulin from the black flying fox (Pteropus alecto)

Frontiers in Immunology
Bats are natural reservoir of viruses that cause severe disease in livestock and humans. Recent high-profile spillover events have directed significant attention towards the relationship between zoonotic viruses and antiviral immunity inherent to bats ...
Jun Jet Hen, Ariel Isaacs, Ariel Isaacs, Benjamin Liang, Tony Schountz, Keith Chappell, Keith Chappell, Keith Chappell, Paul R. Young, Paul R. Young, Paul R. Young, Naphak Modhiran, Naphak Modhiran, Naphak Modhiran, Daniel Watterson, Daniel Watterson, Daniel Watterson   +16 more
doaj   +1 more source

Length determination of the terminal redundant regions in the DNA of phage T7 [PDF]

, 1980
Dreiseikelmann B, Steger U, Wackernagel W. Length determination of the terminal redundant regions in the DNA of phage T7. Molecular and General Genetics.
Steger, Ursula, Dreiseikelmann, Brigitte, Wackernagel, Wilfried   +2 more
core   +1 more source

Camelid VHHs Fused to Human Fc Fragments Provide Long Term Protection Against Botulinum Neurotoxin A in Mice

Toxins, 2019
The bacterium Clostridium botulinum is the causative agent of botulism—a severe intoxication caused by botulinum neurotoxin (BoNT) and characterized by damage to the nervous system. In an effort to develop novel C.
Svetlana A. Godakova, Anatoly N. Noskov, Irina D. Vinogradova, Galina A. Ugriumova, Andrey I. Solovyev, Ilias B. Esmagambetov, Amir I. Tukhvatulin, Denis Y. Logunov, Boris S. Naroditsky, Dmitry V. Shcheblyakov, Aleksandr L. Gintsburg   +10 more
doaj   +1 more source