Results 21 to 30 of about 4,409,486 (250)

Patient characteristics and treatment.

, 2022
AITL: angioimmunoblastic T cell lymphoma; IgG: Immunoglobulin G; IgM: Immunoglobulin M; pos.: positive; neg.: negative; R-CHOP: Rituximab, Cyclophosphamide, Hydroxydaunomycin, Oncovin, and Prednisone; R-ICE: Rituximab, Ifosfamide, Carboplatin, and ...
Simon Völkl (5933276), María Fernanda Lammoglia Cobo (12447023), Julia Ritter (12447026), Regina Gary (269464), Michael Aigner (558382), Stephanie Moi (5198177), Volkhard Seitz (42603), Michael Hummel (197180), Stefanie Schaffer (558381), Armin Gerbitz (174530), Josef Mautner (10677), Steffen Hennig (486995), Heiko Bruns (469100), Anke Seegebarth (12447029), Andreas Mackensen (18003), Maike Büttner-Herold (5280527), Andreas Moosmann (38220), Wolf Rösler (12447032), Kerstin Amann (186160)   +18 more
core   +1 more source

Efgartigimod, an FcRn antagonist, as a potential treatment for post COVID-19 syndrome

Acta Materia Medica, 2023
A significant proportion of patients who survive coronavirus disease of 2019 (COVID-19) develop a constellation of life-altering symptoms that persist long after the initial infection has resolved.
Sandra E. Reznik, Amit K. Tiwari, Charles R. Ashby   +2 more
doaj   +1 more source

Fc-Linked IgG N-Glycosylation in FcγR Knock-Out Mice

Frontiers in Cell and Developmental Biology, 2020
Immunoglobulin G (IgG) is the most abundant immunoglobulin isotype in the blood and is involved in the pathogenesis and progression of various diseases.
Olga O. Zaytseva, Michaela Seeling, Jasminka Krištić, Gordan Lauc, Gordan Lauc, Marija Pezer, Falk Nimmerjahn   +6 more
doaj   +1 more source

Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics

mAbs, 2021
Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the ...
Kathryn H. Ching, Kimberley Berg, Kevin Reynolds, Darlene Pedersen, Alba Macias, Yasmina N. Abdiche, William D. Harriman, Philip A. Leighton   +7 more
doaj   +1 more source

A schematic of the funnel approach that was used to screen for crystallizable NSTs.

, 2023
A schematic of the funnel approach that was used to screen for crystallizable NSTs.
Gowtham Thambra Rajan Premageetha (15332916), Subramanian Ramaswamy (1856344), Sucharita Bose (8958197), Luis M. Bredeston (15332931), Lavanyaa Manjunath (15332922), Vinod Nayak (12151413), Jeff Abramson (3737131), Aviv Paz (2378863), KanagaVijayan Dhanabalan (15332919), Deepthi Joseph (15332925), Samuel Grandfield (15332928)   +10 more
core   +1 more source

Advances in therapeutic Fc engineering - modulation of IgG associated effector functions and serum half-life

Frontiers in Immunology, 2016
Today monoclonal immunoglobulin gamma (IgG) antibodies have become a major option in cancer therapy especially for the patients with advanced or metastatic cancers.
Abhishek Saxena, Donghui Wu
doaj   +1 more source

The N-Glycosylation of Mouse Immunoglobulin G (IgG)-Fragment Crystallizable Differs Between IgG Subclasses and Strains [PDF]

, 2017
N-linked glycosylation of the fragment crystallizable (Fc)-region of immunoglobulin G (IgG) is known to have a large influence on the activity of the antibody, an effect reported to be IgG subclass specific. This situation applies both to humans and mice.
Gordan Lauc, Kristic, J., Ederveen, A.L.H., Karli R. Reiding, Haan, N. de, Manfred Wuhrer, Jasminka Krištić, Lauc, G., Wuhrer, M., Reiding, K.R., Noortje de Haan, Agnes L. Hipgrave Ederveen   +11 more
core   +1 more source

Cloning, expression and characterisation of antigen-specific recombinant bat immunoglobulin from the black flying fox (Pteropus alecto)

Frontiers in Immunology
Bats are natural reservoir of viruses that cause severe disease in livestock and humans. Recent high-profile spillover events have directed significant attention towards the relationship between zoonotic viruses and antiviral immunity inherent to bats ...
Jun Jet Hen, Ariel Isaacs, Ariel Isaacs, Benjamin Liang, Tony Schountz, Keith Chappell, Keith Chappell, Keith Chappell, Paul R. Young, Paul R. Young, Paul R. Young, Naphak Modhiran, Naphak Modhiran, Naphak Modhiran, Daniel Watterson, Daniel Watterson, Daniel Watterson   +16 more
doaj   +1 more source

Camelid VHHs Fused to Human Fc Fragments Provide Long Term Protection Against Botulinum Neurotoxin A in Mice

Toxins, 2019
The bacterium Clostridium botulinum is the causative agent of botulism—a severe intoxication caused by botulinum neurotoxin (BoNT) and characterized by damage to the nervous system. In an effort to develop novel C.
Svetlana A. Godakova, Anatoly N. Noskov, Irina D. Vinogradova, Galina A. Ugriumova, Andrey I. Solovyev, Ilias B. Esmagambetov, Amir I. Tukhvatulin, Denis Y. Logunov, Boris S. Naroditsky, Dmitry V. Shcheblyakov, Aleksandr L. Gintsburg   +10 more
doaj   +1 more source

B Cell-Based Seamless Engineering of Antibody Fc Domains. [PDF]

PLoS ONE, 2016
Engineering of monoclonal antibodies (mAbs) enables us to obtain mAbs with additional functions. In particular, modifications in antibody's Fc (fragment, crystallizable) region can provide multiple benefits such as added toxicity by drug conjugation ...
Koji Hashimoto, Kohei Kurosawa, Akiho Murayama, Hidetaka Seo, Kunihiro Ohta   +4 more
doaj   +1 more source