Results 11 to 20 of about 4,409,486 (250)
Certolizumab Pegol Treatment in Three Patients With Takayasu Arteritis
The Turkish Journal of Gastroenterology, 2019 Although glucocorticoids are the mainstay of treatment in Takayasu arteritis (TA), anti-tumor necrosis factor agents are other treatment options in refractory disease. The onset of TA is generally observed in females of reproductive age.
Nuh ATAŞ +5 more
doaj +3 more sources
Molecular Therapy: OncologyNeospora caninum, a potential anticancer agent able to reactivate the immune response within the tumor microenvironment (TME), has recently shown enhanced immunomodulatory properties in different tumor models when armed with the cytokine, Il-15.
Clément Riviere +11 more
doaj +2 more sources
Lasso-grafted designer cytokines [PDF]
, 2023 Cytokine receptor agonists can be designed with longer half-lives in circulation and with enhanced penetration of the blood-brain barrier by genetically grafting macrocyclic peptides into the structural loops of fragment crystallizable ...
Bernhagen, Jurgen, Kapurniotu, Aphrodite
core +1 more source
PLoS ONE, 2021 Mycobacterium tuberculosis (Mtb) infects one-quarter of the world's population. Mtb and HIV coinfections enhance the comorbidity of tuberculosis (TB) and AIDS, accounting for one-third of all AIDS-associated mortalities.
Hui-Chen Chang Foreman +2 more
doaj +1 more source
Chimeric single-chain variable fragment-human immunoglobulin G crystallizable fragment antibody against GD2 for neuroblastoma targeted immunotherapy [PDF]
, 2023 Aim: The present study aims to generate chimeric mouse single-chain variable fragment (scFv) and immunoglobulin G1 (IgG1) crystallizable fragment (Fc) antibody against disialoganglioside (GD2) for the treatment of neuroblastoma (NB).
Watchara Kasinrerk +5 more
core +1 more source
Generating Recombinant Antibodies against Putative Biomarkers of Retinal Injury. [PDF]
PLoS ONE, 2015 Candidate biomarkers, indicative of disease or injury, are beginning to overwhelm the process of validation through immunological means. Recombinant antibodies developed through phage-display offer an alternative means of generating monoclonal antibodies
Michael R Kierny +4 more
doaj +1 more source
A Method to Detect the Binding of Hyper-Glycosylated Fragment Crystallizable (Fc) Region of Human IgG1 to Glycan Receptors. [PDF]
, 2018 Engineering the fragment crystallizable (Fc) of human IgG can bring improved effector functions to monoclonal antibodies and Fc-fusion-based medicines and vaccines.
Blundell, Pat, Pleass, Richard
core +1 more source
Cobalt-Directed Assembly of Antibodies onto Metal-Phenolic Networks for Enhanced Particle Targeting. [PDF]
, 2020 The orientation-specific immobilization of antibodies onto nanoparticles, to preserve antibody-antigen recognition, is a key challenge in developing targeted nanomedicines.
Richardson, JJ +11 more
core +3 more sources
Half-Life Extension Enhances Drug Efficacy in Adeno-Associated Virus Delivered Gene Therapy
Engineering, 2023 Prolonged half-life of protein-based therapeutics can improve drug efficacy. However, the impact of drug half-life on gene therapy, which inherently provides long-lasting production of the desired therapeutic protein, remains unclear.
Huifang Wu +13 more
doaj +1 more source
Next generation Fc scaffold for multispecific antibodies
iScience, 2021 Summary: Bispecific antibodies (Bispecifics) demonstrate exceptional clinical potential to address some of the most complex diseases. However, Bispecific production in a single cell often requires the correct pairing of multiple polypeptide chains for ...
Bram Estes +11 more
doaj +1 more source