Results 31 to 40 of about 8,345 (257)

Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics

mAbs, 2021
Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the ...
Kathryn H. Ching, Kimberley Berg, Kevin Reynolds, Darlene Pedersen, Alba Macias, Yasmina N. Abdiche, William D. Harriman, Philip A. Leighton   +7 more
doaj   +1 more source

Immunoglobulin G fragment crystallizable glycosylation after hematopoietic stem cell transplantation is dissimilar to donor profiles [PDF]

, 2018
Immunoglobulin G (IgG) fragment crystallizable (Fc) N-glycosylation has a large influence on the affinity of the antibody for binding to Fcγ-receptors (FcγRs) and C1q protein, thereby influencing immune effector functions.
de Haan, N. (Noortje), Driessen, G.J.A. (Gertjan), Lankester, A.C. (Arjan), Tol, M.J.D. (Marie-José) van, Wuhrer, M. (Manfred)   +4 more
core   +3 more sources

Advances in therapeutic Fc engineering - modulation of IgG associated effector functions and serum half-life

Frontiers in Immunology, 2016
Today monoclonal immunoglobulin gamma (IgG) antibodies have become a major option in cancer therapy especially for the patients with advanced or metastatic cancers.
Abhishek Saxena, Donghui Wu
doaj   +1 more source

Expression, Purification, and Biophysical Characterization of a Secreted Anthrax Decoy Fusion Protein in Nicotiana benthamiana. [PDF]

, 2017
Anthrax toxin receptor-mediated drug development for blocking anthrax toxin action has received much attention in recent decades. In this study, we produced a secreted anthrax decoy fusion protein comprised of a portion of the human capillary ...
Dandekar, Abhaya M, Duhra-Gill, Sifti, Kailemia, Muchena J, Karuppanan, Kalimuthu, Lebrilla, Carlito B, McDonald, Karen A, Nandi, Somen, Phu, My L, Rodriguez, Raymond L   +8 more
core   +2 more sources

B Cell-Based Seamless Engineering of Antibody Fc Domains. [PDF]

PLoS ONE, 2016
Engineering of monoclonal antibodies (mAbs) enables us to obtain mAbs with additional functions. In particular, modifications in antibody's Fc (fragment, crystallizable) region can provide multiple benefits such as added toxicity by drug conjugation ...
Koji Hashimoto, Kohei Kurosawa, Akiho Murayama, Hidetaka Seo, Kunihiro Ohta   +4 more
doaj   +1 more source

Forced Degradation Testing as Complementary Tool for Biosimilarity Assessment [PDF]

, 2019
Oxidation of monoclonal antibodies (mAbs) can impact their efficacy and may therefore represent critical quality attributes (CQA) that require evaluation.
Dyck, Yan Felix Karl, Jabs, Wolfgang, Joseph, Jan Felix, Parr, Maria Kristina, Rehm, Daniel, Sandig, Volker, Winkler, Karsten   +6 more
core   +1 more source

Cloning, expression and characterisation of antigen-specific recombinant bat immunoglobulin from the black flying fox (Pteropus alecto)

Frontiers in Immunology
Bats are natural reservoir of viruses that cause severe disease in livestock and humans. Recent high-profile spillover events have directed significant attention towards the relationship between zoonotic viruses and antiviral immunity inherent to bats ...
Jun Jet Hen, Ariel Isaacs, Ariel Isaacs, Benjamin Liang, Tony Schountz, Keith Chappell, Keith Chappell, Keith Chappell, Paul R. Young, Paul R. Young, Paul R. Young, Naphak Modhiran, Naphak Modhiran, Naphak Modhiran, Daniel Watterson, Daniel Watterson, Daniel Watterson   +16 more
doaj   +1 more source

Camelid VHHs Fused to Human Fc Fragments Provide Long Term Protection Against Botulinum Neurotoxin A in Mice

Toxins, 2019
The bacterium Clostridium botulinum is the causative agent of botulism—a severe intoxication caused by botulinum neurotoxin (BoNT) and characterized by damage to the nervous system. In an effort to develop novel C.
Svetlana A. Godakova, Anatoly N. Noskov, Irina D. Vinogradova, Galina A. Ugriumova, Andrey I. Solovyev, Ilias B. Esmagambetov, Amir I. Tukhvatulin, Denis Y. Logunov, Boris S. Naroditsky, Dmitry V. Shcheblyakov, Aleksandr L. Gintsburg   +10 more
doaj   +1 more source

Transient proteolysis reduction of Nicotiana benthamiana-produced CAP256 broadly neutralizing antibodies using CRISPR/Cas9

Frontiers in Plant Science, 2022
The hypersensitive response is elicited by Agrobacterium infiltration of Nicotiana benthamiana, including the induction and accumulation of pathogenesis-related proteins, such as proteases.
Advaita Acarya Singh, Advaita Acarya Singh, Priyen Pillay, Previn Naicker, Kabamba Alexandre, Kanyane Malatji, Lukas Mach, Herta Steinkellner, Juan Vorster, Rachel Chikwamba, Tsepo L. Tsekoa   +10 more
doaj   +1 more source

Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy. [PDF]

, 2017
At birth, neonates are particularly vulnerable to infection and transplacental transfer of immunoglobulin G (IgG) from mother to fetus provides crucial protection in the first weeks of life.
Abdiche, Abourawi, Abu-Raya, Amirthalingam, Amirthalingam, Antohe, Atwell, Bainbridge, Bakchoul, Baker, Baker, Basha, Bialas, Bondt, Brair, Brambell, Brambell, Brambell, Bruhns, Calderon, Calvert, Cavalcante, Chen, Chu, Cumberland, Dabrera, Dashivets, de Moraes-Pinto, de Souza, Dillon, Einarsdottir, Einarsdottir, Ellinger, Ellinger, Englund, Faucette, Faucette, Firan, Fowden, França, Fu, Gaither, Gall, Goldfarb, Griffiths, Hamilton, Hammes, Hanson, Hartter, Hashira, Heath, Heidl, Henkle, Heron, Holder, Holland, Hornby, Huhn, Jansen, Jauniaux, Jefferis, Jones, Junghans, Kennedy, Kibe, Kim, Kim, Kim, Kohler, Kristoffersen, Ladhani, Leach, Leitner, Li, Li, Lightle, Madhi, Maertens, Malek, Malek, Mammaro, Martin, Martins, Mathiesen, Mathiesen, Medesan, Mestas, Mimura, Mitchell, Mohanty, Montano, Moore, Myllynen, Neuber, Niewiesk, Ober, Ober, Oganesyan, Okoko, Okoko, Okoko, Okoko, Omata, Osendarp, Palmeira, Palmer, Poehling, Porter, Poulsen, Powner, Qiao, Raghavan, Raghavan, Reynolds, Roux, Sand, Saso, Schlaudecker, Schofield, Scott, Sgarbosa, Silveira Lessa, Simister, Simister, Simister, Stach, Stapleton, Stapleton, Syme, Tabata, Takizawa, Tapia, Thomann, Tzaban, van den Berg, van den Berg, Viall, Vidarsson, Vidarsson, Vogelzang, Vähäkangas, West, Williams, Winter, Wormald, Wypych, Zaman, Zhu   +147 more
core   +2 more sources