Results 31 to 40 of about 4,409,486 (250)
Relative composition (%) of N-glycans in original and enzyme-treated IVIG.
, 2014 -; The amount is less than 2% of the total.n.d.; not detected.Abbreviations: Fab, Fragment, antigen-binding region; Fc, Fragment crystallizable region; GalT, galactosyltransferase; IVIG, intravenous immunoglobulin; PNGaseF, peptide: N-glycosidase F; SiaT,
Nobuhiro Yuki (60770) +6 more
core +1 more source
Frontiers in Plant Science, 2022 The hypersensitive response is elicited by Agrobacterium infiltration of Nicotiana benthamiana, including the induction and accumulation of pathogenesis-related proteins, such as proteases.
Advaita Acarya Singh +10 more
doaj +1 more source
The distribution of Fc receptor expression in placental villous trees.
, 2018 Maternal IgG present in the intervillous space crosses through distinct cell barriers, including syncytiotrophoblasts, the villous stroma which contains Hofbauer cells and fibroblasts, and fetal endothelial cells.
Xinxia Peng (259508) +4 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
PharmaceuticsMonoclonal antibodies are commonly engineered with an introduction of Met428Leu and Asn434Ser, known as the LS mutation, in the fragment crystallizable region to improve pharmacokinetic profiles.
Bryan T. Mayer +29 more
doaj +1 more source
Biological Active Region Defined by Fragment-based Molecular Theory [PDF]
Computational chemistry studies using the QM/MM approach have been conducted to explain and predict protein functions. However, the active regions responsible for those functions often need to be clarified.
Hirotoshi, Mori +2 more
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
, 2019 Schematic of the cytotoxic effect of DS-8895a. Abbreviations: EPHA2, erythropoietin-producing hepatocellular receptor A2; FcÎłRIIIa, Fragment crystallizable gamma receptor IIIa; NK, natural killer.
Kensei Yamaguchi (3626987) +14 more
core +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Maternal antibody passive transfer and functional activity in the neonate.
, 2020 (A) IgG passive transfer in the placenta influences FcγR-mediated cell cytotoxicity, phagocytosis, and complement activation in the developing fetus/newborn.
Stephanie N. Langel (6626651) +3 more
core +1 more source