Results 91 to 100 of about 723,628 (294)

Fragmentation of Biologically Important Molecules by the use of soft Ionization Methods

open access: yes, 2019
In this thesis I have studied the fragmentation of biological important molecules with soft ionization methods. Through this thesis I studied and analyzed the fragmentation pattern and how they defer depending on the alcohol solvent used.
Ojo, Olufunmilola Samuel
core  

Patterns of International Fragmentation of Production and Implications for the Labor Markets [PDF]

open access: yes
Growing shares of international trade flows consist of intermediate and unfinished goods shipped from one country to another to combine manufacturing or services activities at home with those performed abroad.
Lucia Tajoli, Rodolfo Helg
core   +2 more sources

Elevated Levels of Herbivory in Urban Landscapes: Are Declines in Tree Health More Than an Edge Effect?

open access: yesEcology and Society, 2005
Urbanization is one of the most extreme and rapidly growing anthropogenic pressures on the natural world. Urban development has led to substantial fragmentation of areas of natural habitat, resulting in significant impacts on biodiversity and disruptions
Fiona J. Christie, Dieter F. Hochuli
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Fragmentation of Organic Complexes Under Mass Spectrometry

open access: yes, 2022
In the thesis, fragmentation of the metallic, organic complexes were discussed and studied under mass spectrometry. We utilized the Bruker software to identify all the compounds and their fragments.
Aliyeva, Zenfira
core  

Fibril Fragmentation Enhances Amyloid Cytotoxicity [PDF]

open access: yes, 2009
Fibrils associated with amyloid disease are molecular assemblies of key biological importance, yet how cells respond to the presence of amyloid remains unclear. Cellular responses may not only depend on the chemical composition or molecular properties of
Xue, Wei-Feng   +5 more
core   +1 more source

Modelling of Fluid Fragmentation by Molecular Dynamics [PDF]

open access: yes, 2013
In the present work, numerous molecular dynamics simulations of fragmentation of expanding Lennard-Jones (LJ) fluids have been performed. Two types of expansion were considered: that of Holian and Grady, and that of Blink and Hoover.
Stepanov, Igor
core   +3 more sources

Chronic Insomnia Is Associated with Higher Circulating Interleukin-8 in Patients with Atherosclerotic Cerebral Small Vessel Disease

open access: yesNature and Science of Sleep, 2020
Jihui Wang,1 Xiaodong Chen,2 Xuejiao Men,2 Minhua Chen,1 Jiong Tao,1 Zhengqi Lu2 1Department of Psychiatry, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, People’s Republic of China; 2Department of Neurology, the Third ...
Wang J   +5 more
doaj  

A Systematic Comparison of Cultural and Ecological Landscape Corridors in Europe

open access: yesLand, 2019
Landscape corridors are narrow strips of land that differ from the matrix on either side. In addition to providing connectivity between fragmented landscapes, these corridors serve scenic, cultural, social, ecological, and recreational purposes.
Haiyun Xu   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

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