Results 101 to 110 of about 1,331,169 (299)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

The non-singlet kaon fragmentation function from e^+e^- kaon production

open access: yes, 2010
We perform fits to the available charged and neutral kaon production data in $e^++e^-\to K+X$, $K=K^\pm and K^0_S$, and determine the non-singlet combination of kaon fragmentation functions $D_u^{K^\pm}-D_d^{K^\pm}$ in a model independent way and without
Albino, S., Christova, E.
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Elevated Levels of Herbivory in Urban Landscapes: Are Declines in Tree Health More Than an Edge Effect?

open access: yesEcology and Society, 2005
Urbanization is one of the most extreme and rapidly growing anthropogenic pressures on the natural world. Urban development has led to substantial fragmentation of areas of natural habitat, resulting in significant impacts on biodiversity and disruptions
Fiona J. Christie, Dieter F. Hochuli
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Chronic Insomnia Is Associated with Higher Circulating Interleukin-8 in Patients with Atherosclerotic Cerebral Small Vessel Disease

open access: yesNature and Science of Sleep, 2020
Jihui Wang,1 Xiaodong Chen,2 Xuejiao Men,2 Minhua Chen,1 Jiong Tao,1 Zhengqi Lu2 1Department of Psychiatry, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, People’s Republic of China; 2Department of Neurology, the Third ...
Wang J   +5 more
doaj  

A Systematic Comparison of Cultural and Ecological Landscape Corridors in Europe

open access: yesLand, 2019
Landscape corridors are narrow strips of land that differ from the matrix on either side. In addition to providing connectivity between fragmented landscapes, these corridors serve scenic, cultural, social, ecological, and recreational purposes.
Haiyun Xu   +2 more
doaj   +1 more source

Production of neutron-rich nuclei in fragmentation reactions of 132Sn projectiles at relativistic energies

open access: yes, 2011
The fragmentation of neutron-rich 132Sn nuclei produced in the fission of 238U projectiles at 950 MeV/u has been investigated at the FRagment Separator (FRS) at GSI. This work represents the first investigation of fragmentation of medium-mass radioactive
A. Heinz   +47 more
core   +3 more sources

Fragments, fragmentations

open access: yesCalenda, 2019
Le topique du fragment est transversal à l’ensemble des sciences humaines et sociales. Il s’y décline diversement comme autant de modalités d’une incomplétude et souvent, par extension, d’une déficience. Les séances de ce séminaire viseront à identifier les potentialités du fragment en tant que tel pour l’investigation scientifique.
openaire   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

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