Results 101 to 110 of about 723,628 (294)
Bioscience Journal, 2016 The bush dog (Speothos venaticus) is a Neotropical canid with a wide geographic distribution. Although globally listed as Near Threatened, this species was listed as Vulnerable in a recent assessment by the Brazilian government.
Fernanda Cavalcanti Azevedo +4 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Determinants of International Fragmentation of Production in the European Union [PDF]
The last decades were characterized by large increases in world trade, not only in absolute terms, but also in relation to world GDP. This was in large parts caused by increasing exchanges of parts and components between countries as a consequence of ...
Götz Zeddies
core
Consequences of asteroid fragmentation during impact hazard mitigation [PDF]
, 2009 The consequences of the fragmentation of an Earth-threatening asteroid due to an attempted deflection are examined in this paper. The minimum required energy for a successful impulsive deflection of a threatening object is computed and compared to the ...
Vasile, M. +9 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Journal of Landscape Ecology, 2017 The study assessed the patterns of spatio-temporal configuration imposed on a forest landscape in Southwestern Nigeria due to fragmentation for the period 1986 – 2010 in order to understand the relationship between landscape patterns and the ecological ...
Adepoju Kayode Adewale +1 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Crushed Aid: Fragmentation in Sectoral Aid [PDF]
This paper measures and compares fragmentation in aid sectors. Past studies focused on aggregate country data but a sector analysis provides a better picture of fragmentation.
Santiso, Javier, Frot, Emmanuel
core
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source