Results 81 to 90 of about 417,831 (266)
Ecology and Society, 2005 Urbanization is one of the most extreme and rapidly growing anthropogenic pressures on the natural world. Urban development has led to substantial fragmentation of areas of natural habitat, resulting in significant impacts on biodiversity and disruptions
Fiona J. Christie, Dieter F. Hochuli
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Nature and Science of Sleep, 2020 Jihui Wang,1 Xiaodong Chen,2 Xuejiao Men,2 Minhua Chen,1 Jiong Tao,1 Zhengqi Lu2 1Department of Psychiatry, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, People’s Republic of China; 2Department of Neurology, the Third ...
Wang J +5 more
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A Systematic Comparison of Cultural and Ecological Landscape Corridors in Europe
Land, 2019 Landscape corridors are narrow strips of land that differ from the matrix on either side. In addition to providing connectivity between fragmented landscapes, these corridors serve scenic, cultural, social, ecological, and recreational purposes.
Haiyun Xu +2 more
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Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
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Bioscience Journal, 2016 The bush dog (Speothos venaticus) is a Neotropical canid with a wide geographic distribution. Although globally listed as Near Threatened, this species was listed as Vulnerable in a recent assessment by the Brazilian government.
Fernanda Cavalcanti Azevedo +4 more
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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Journal of Landscape Ecology, 2017 The study assessed the patterns of spatio-temporal configuration imposed on a forest landscape in Southwestern Nigeria due to fragmentation for the period 1986 – 2010 in order to understand the relationship between landscape patterns and the ecological ...
Adepoju Kayode Adewale +1 more
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FRAGMENTATION AND HADRONIZATION [PDF]
International Journal of Modern Physics A, 2000 31 pages, 33 figures. Plenary talk at XIX International Symposium on Lepton and Photon Interactions at High Energies, Stanford, August ...
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