Results 61 to 70 of about 416,094 (266)
Fragmentation and Integration [PDF]
, 2021 Abstract This chapter is a response to the previous three chapters, in which it is argued that the relative weight of the Roman Empire was different between the West and the Abbasid caliphate, meaning that the categories of Sameness and Otherness that developed in the wake of the rise of Christendom in the West are not readily applicable
openaire +2 more sources
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Компьютерная оптикаOptimization of open-pit mining is one of significant tasks to date, with the blasting quality estimation being a key factor. The blasting quality is determined through evaluating the number of fragments and block size distribution, the so-called ...
K. Reshetnikov, M. Ronkin , S. Porshnev
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Spatio-temporal variation in snow cover area and its fragmentation in Northeast China
Frontiers in Earth ScienceUnder the backdrop of climate warming and changes in snow cover area, the spatial fragmentation characteristics of snow cover need to be studied in depth.
Jiakai Gu +7 more
doaj +1 more source
Fragmentation, Orality and Magic Realism in Kezilahabi's Novel Nagona
Nordic Journal of African Studies, 2003 This article is a response to Gromov's article entitled Nagona and Mzingile: Novel, Tale or Parable? Contrary to Gromov's thesis on the structural ambiguity of the novel, we posit that the structure of this novel is discernible if we consider the ...
Said A. M. Khamis
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source