Results 121 to 130 of about 1,654,002 (384)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

High Pt hadron-hadron correlations

, 2004
We propose the formulation of a dihadron fragmentation function in terms of parton matrix elements. Under the collinear factorization approximation and facilitated by the cut-vertex technique, the two hadron inclusive cross section at leading order (LO ...
A Majumder, Collins J C, Di Nezza P, Dokshitzer Yu L, Gribov V N, Majumder A Wang E Wang X N, Majumder A Wang X N, Mueller A H, Xin-Nian Wang   +8 more
core   +1 more source

Propagating annotations of molecular networks using in silico fragmentation

PLoS Comput. Biol., 2018
The annotation of small molecules is one of the most challenging and important steps in untargeted mass spectrometry analysis, as most of our biological interpretations rely on structural annotations.
Ricardo R. da Silva, Mingxun Wang, Louis-Félix Nothias, J. J. Hooft, A. Caraballo-Rodríguez, E. Fox, Marcy J. Balunas, J. Klassen, N. Lopes, P. Dorrestein   +9 more
semanticscholar   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Florística de lianas em um fragmento de floresta estacional semidecidual, Parque Estadual de Vassununga, Santa Rita do Passa Quatro, SP, Brasil Floristic of lianas in a fragment of seasonal semidecidual forest State Park of Vassununga, Santa Rita do Passa Quatro, São Paulo State, Brazil

Acta Botânica Brasílica, 2006
Embora o conhecimento sobre a florística dos fragmentos de florestas estacionais semideciduais tenha crescido nos últimos anos, ainda sabe-se pouco sobre a comunidade de lianas (lenhosas ou herbáceas) nesses fragmentos.
Yara Junqueira de Azevedo Tibiriçá, Luis Francisco Mello Coelho, Leila Cunha de Moura   +2 more
doaj   +1 more source

Systematic study of the jet fragmentation function for inclusive jet-production in p+p collisions at sqrt{s}=200 GeV in STAR

, 2008
Jet fragmentation functions measured in e^+e^- and p+\bar{p} experiments are well-described on an inclusive hadron level by QCD-based calculations.
B. Abelev, B. Abelev, B. Abelev, D. Acosta, J. Adams, J. Adams, M. Cacciari, Mark Heinz, S. Sapeta, T. Sjostrand, Y.L. Dokshitzer, Y.L. Dokshitzer   +11 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Donor fragmentation [PDF]

This chapter explains the incentives facing donors that lead them to fragment their foreign aid effortis over a large number of recipients, sectros, and projects.
Knack, Stephen, Rahman, Aminur
core   +1 more source