Results 81 to 90 of about 164 (114)

Clinical Variables and Cell-Free DNA Fragmentomics: Biological and Clinical Insights

Clinical Chemistry
Yasine, Malki, Y M Dennis, Lo
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Fragmentomics features of cell free DNA in eating disorders

Translational Psychiatry
Alisa Burova, Camille Verebi, Nicolas Lebrun, Juliette Nectoux, Audrey Boutonnet, Philibert Duriez, Philip Gorwood, Nicolas Ramoz, Thierry Bienvenu   +8 more
openaire   +1 more source

Exploring global cfDNA fragmentomics as a biomarker in real-world patients with melanoma

Journal of Investigative Dermatology
Daniel Rizo-Potau, Anton Forniés-Mariné, José Luis Villanueva-Cañas, Michelle Aguilar, Cristina Sánchez-Cárdenas, Teresa Torres, Sebastian Podlipnik, Cristina Carrera, Susana Puig, Josep Malvehy, Joan Anton Puig-Butillé   +10 more
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Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection [PDF]

Cancer Discovery
Lung cancer screening via annual low-dose computed tomography (LDCT) has poor adoption. We conducted a prospective case-control study among 958 individuals eligible for lung cancer screening to develop a blood-based lung cancer detection test that when ...
Peter Bach, Joseph L Catallini, Kwok Kin Wong   +2 more
exaly   +5 more sources

Cell-free DNA fragmentome analysis informs pregnancy outcome in patients with immune-mediated disease.

Science Translational Medicine
Pregnancy complications contribute substantially to maternal and fetal morbidity and mortality. If complications are suspected early in pregnancy, individuals could be triaged to escalate care and ideally reduce adverse outcomes.
Erika Souche, Kristel van Calsteren, Kate E Stanley   +2 more
exaly   +2 more sources

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Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies

Science, 2021
Enhancing liquid biopsies Liquid biopsies, analyses of cell-free DNA that circulates in the blood, can be used in prenatal testing, oncology, and to monitor organ transplant recipients. Lo et al. review the nongenetic information that can be gleaned from analyses of cell-free DNA, which offers additional ...
Y. M. Dennis Lo, Diana S. C. Han, Peiyong Jiang, Rossa W. K. Chiu   +3 more
openaire   +2 more sources

Fragmentomic analysis of circulating tumor DNA-targeted cancer panels

Annals of Oncology, 2023
The isolation of cell-free DNA (cfDNA) from the bloodstream can be used to detect and analyze somatic alterations in circulating tumor DNA (ctDNA), and multiple cfDNA-targeted sequencing panels are now commercially available for Food and Drug Administration (FDA)-approved biomarker indications to guide treatment.
K T, Helzer, M N, Sharifi, J M, Sperger, Y, Shi, M, Annala, M L, Bootsma, S R, Reese, A, Taylor, K R, Kaufmann, H K, Krause, J L, Schehr, N, Sethakorn, D, Kosoff, C, Kyriakopoulos, M E, Burkard, N R, Rydzewski, M, Yu, P M, Harari, M, Bassetti, G, Blitzer, J, Floberg, M, Sjöström, D A, Quigley, S M, Dehm, A J, Armstrong, H, Beltran, R R, McKay, F Y, Feng, R, O'Regan, K B, Wisinski, H, Emamekhoo, A W, Wyatt, J M, Lang, S G, Zhao   +33 more
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Fragmentomics of proteins and natural oligopeptides

Biophysics, 2008
The term fragmentomics is grounded and defined. Theoretical structure-function analysis of all possible fragments of a protein molecule was performed under the concept of fragmentomics to determine the regions that could be potential sources of regulatory oligopeptides.
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A method of comprehensive sequencing analysis of the small RNA fragmentome (RiboMarker).

Rna
Circulating cell-free nucleic acids (cfDNA and cfRNA) found in blood and other biofluids are promising biomarkers for cancer. However, current methods exploiting tumor-derived cfDNA (ctDNA) are not sensitive enough in detecting minimal residual disease and early stages of cancer when it is more treatable.
Sergio Barberan-Soler, Sergei A Kazakov
exaly   +3 more sources

Multidimensional Fragmentomics Enables Early and Accurate Detection of Colorectal Cancer

Cancer Research
Abstract Colorectal cancer is frequently diagnosed in advanced stages, highlighting the need for developing approaches for early detection. Liquid biopsy using cell-free DNA (cfDNA) fragmentomics is a promising approach, but the clinical application is hindered by complexity and cost.
Yuepeng Cao, Nannan Wang, Xuxiaochen Wu, Wanxiangfu Tang, Hua Bao, Chengshuai Si, Peng Shao, Dongzheng Li, Xin Zhou, Dongqin Zhu, Shanshan Yang, Fufeng Wang, Guoqing Su, Ke Wang, Qifan Wang, Yao Zhang, Qiangcheng Wang, Dongsheng Yu, Qian Jiang, Jun Bao, Liu Yang   +20 more
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