Results 71 to 80 of about 303 (142)

Next-generation MRD assays: do we have the tools to evaluate them properly?

, 2023
Circulating tumour DNA (ctDNA) detection of molecular residual disease (MRD) in solid tumours correlates strongly with patient outcomes and is being adopted as a new clinical standard.
Abbosh, Chris, Dougherty, Brian, Labrousse, Paul, Hodgson, Darren, Russell, Hugh, Stetson, Dan, Barrett, J. Carl, Shera, David, Hadfield, James   +8 more
core  

Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA

Advanced Science
ABSTRACT Cell‐free DNA (cfDNA) in plasma consists of short DNA fragments resulting from a non‐random fragmentation process, with distinct fragmentomic characteristics that are related with their cellular origins. Here, we report that somatic variant signatures in cfDNA markedly differ between non‐cancerous controls and cancer patients,
Zhenyu Zhang, Yunyun An, Mengqi Yang, Yuqi Pan, Xiaoyi Liu, Fanglei Gong, Huizhen Lin, Bianbian Tang, Yunxia Bai, Xin Zhao, Yu Zhao, Changzheng Du, Kun Sun   +12 more
openaire   +2 more sources

Cell-Free DNA Fragmentome Dynamics as a Biomarker for Immune-Checkpoint Inhibition in Advanced Carcinoma

International audienceEarly prediction of resistance to immunotherapy is a major challenge in oncology. The ongoing SChISM (Size Cell-fre DNA (cfDNA) Immunotherapies Signature Monitoring) clinical study proposes an innovative approach based on patented ...
Boutonnet, Audrey, Fina, Frederic, Della-Negra, Lucie, Nguyen Phuong, Linh, Tomasini, Pascale, Greillier, Laurent, Garcia, Jean-Charles, Salas, Sébastien, Ginot, Frédéric, Zakrajsek, Romain, Deville, Jean-Laurent, Benzekry, Sébastien   +11 more
core   +1 more source

Circulating cell-free DNA size distribution as a prediction marker for early progression undergoing immune checkpoint inhibitors

International audienceIntroduction: Despite a significant proportion (20 to 40%)[1] of advanced cancer patients having long-term response to treatment with immune checkpoint inhibitors (ICI), many of them do not respond at all and experience early ...
Boutonnet, Audrey, Fina, Frederic, Nguyen Phuong, Linh, Greillier, Laurent, Gaudy-Marqueste, Caroline, Salas, Sébastien, Ginot, Frédéric, Deville, Jean-Laurent, Benzekry, Sébastien   +8 more
core   +3 more sources

pyfraglib : An integrated cfDNA fragmentomics platform

Abstract Summary Cell-free DNA (cfDNA) fragmentomics is the analysis of a diverse set of cfDNA fragment features, e.g. fragment length profiles, windowed protection scores, and end motifs. As such it requires software tooling for fragment extraction, statistical feature modeling,
Daniel Schuette, Laura K. Godfrey, Jessica Schneider, Sven Borchmann, Jan-Michel Heger, Roland F. Schwarz   +5 more
openaire   +1 more source

Sizing and concentration analysis of cfDNA using Biabooster technology: Results from a prospective plasma‐based collection of 77 patients with locally advanced unresectable esophageal cancer

International audienceAbstract Locally advanced esophageal carcinoma remains of poor prognosis correlated with tumor stage. Albeit liquid biopsy approach offers promising results to monitor high‐risk patients in various solid tumors, the lack of specific
Le Sourd, Samuel, Jouve, Ariane Darut, Gibert, Sophie, Taillez, Alexandre, Modesto, Anouchka, Vendrely, Véronique, Seva, Catherine, Delmas, Caroline, Ronchin, Philippe, Leignel, Delphine Argo, Guimbaud, Rosine, Moyal, Elizabeth, Riou, Olivier, Delord, Jean Pierre, Cordelier, Pierre, Pezzella, Veronica, Paumier, Amaury, Martin-Babau, Jérôme, Tougeron, David, Leroy, Thomas, Quéro, Laurent, Hanoun, Naïma   +21 more
core   +1 more source

Integrating tumor kinetics and circulating cell-free DNA markers through mechanistic modeling for early prediction of immunotherapy response

International audienceMany cancer patients undergoing immune-checkpoint inhibition (ICI) experience early progression(EP), defined as progression at the first imaging evaluation.
Fina, Frederic, Nguyen Phuong, Linh, Greillier, Laurent, Gaudy-Marqueste, Caroline, Garcia, Jean-Charles, Salas, Sébastien, Deville, Jean-Laurent, Benzekry, Sébastien   +7 more
core   +1 more source

qMAP decodes RNA fragmentation dynamics in development and disease

Noncanonical small RNAs, such as tRNA-derived (tsRNAs) and rRNA-derived (rsRNAs) fragments, are more abundant than microRNAs and arise from selective cleavage events rather than random degradation.
Chen Cai, Tong Zhou, Jiancheng Yu, Hukam C Rawal, Xudong Zhang, Qi Chen   +5 more
core   +1 more source

Commentary: Techniques for removal of posteriorly dislocated lens fragment. [PDF]

Indian J Ophthalmol, 2023
Babu N, Kohli P.
europepmc   +1 more source

Peptide MS/MS-fragmentome

, 2015

core   +1 more source