Results 81 to 90 of about 222 (122)

Mechanistic Modeling of cfDNA Fragmentome Dynamics Predicts Progression to Immunotherapy

BackgroundPlasma cell-free DNA (cfDNA) shows promise as predictive cancer biomarker, but mechanisms governing cfDNA production/fragmentation/elimination dynamics, and their relationships with tumor burden and disease progression, remain poorly understood.Methods We developed a mechanistic model jointly describing short (75-<580 bp) and long (≥580 ...
Nguyen Phuong, Linh, Fina, Frédéric, Greillier, Laurent, Tomasini, Pascale, Deville, Jean-Laurent, Boutonnet, Audrey, Ginot, Frédéric, Garcia, Jean-Charles, Salas, Sebastien, Benzekry, Sébastien   +9 more
openaire   +1 more source

Large language model produces high accurate diagnosis of cancer from end-motif profiles of cell-free DNA. [PDF]

Brief Bioinform
Liu J, Shen H, Chen K, Li X.
europepmc   +1 more source

Liquid Biopsy in Early Screening of Cancers: Emerging Technologies and New Prospects. [PDF]

Biomedicines
Zhu H, Li Z, Xie K, Kassim SH, Cao C, Huang K, Lu Z, Ma C, Li Y, Jiang K, Yin L.   +10 more
europepmc   +1 more source

Development of a deep learning model for cancer diagnosis by inspecting cell-free DNA end-motifs. [PDF]

NPJ Precis Oncol
Shen H, Yang M, Liu J, Chen K, Li X.
europepmc   +1 more source

Fragmentomics features of cell free DNA in eating disorders

Translational Psychiatry
Alisa Burova, Camille Verebi, Nicolas Lebrun, Juliette Nectoux, Audrey Boutonnet, Philibert Duriez, Philip Gorwood, Nicolas Ramoz, Thierry Bienvenu   +8 more
openaire   +1 more source

Clinical Variables and Cell-Free DNA Fragmentomics: Biological and Clinical Insights

Clinical Chemistry
Yasine, Malki, Y M Dennis, Lo
openaire   +2 more sources

Novel Biomarkers in Hepatocellular Carcinoma from Embryogenic Antigens to cfDNA. [PDF]

Biomedicines
Ghantus R, Ciocan RA, Schlanger D, Popa C, Gherman CD, Vaida C, Gherman B, Pîslă D, Al Hajjar N, Ciocan A.   +9 more
europepmc   +1 more source

Cell-free DNA methylome and fragmentome analysis for disease relapse monitoring in patients with Ewing Sarcoma

Richardson SA, Gulati G, Harker PJ, Redfern A, Pearce SP, Karimpour M, Hill SM, Makeev VJ, Brennan B, Lee AT, Clipson A, Dive C, Rothwell DG, McCabe MG, Mouliere F.   +14 more
europepmc   +1 more source

Genome-wide analyses of cell-free DNA for therapeutic monitoring of patients with pancreatic cancer. [PDF]

Sci Adv
Hruban C, Bruhm DC, Chen IM, Koul S, Annapragada AV, Vulpescu NA, Short S, Theile S, Boyapati K, Alipanahi B, Skidmore ZL, Leal A, Cristiano S, Adleff V, Johannsen JS, Scharpf RB, Foda ZH, Phallen J, Velculescu VE.   +18 more
europepmc   +1 more source

Early Changes in Tumor-Naive Cell-Free Methylomes and Fragmentomes Predict Outcomes in Pembrolizumab-Treated Solid Tumors. [PDF]

Cancer Discov
Stutheit-Zhao EY, Sanz-Garcia E, Liu ZA, Wong D, Marsh K, Abdul Razak AR, Spreafico A, Bedard PL, Hansen AR, Lheureux S, Torti D, Lam B, Yang SYC, Burgener J, Luo P, Zeng Y, Cheng N, Awadalla P, Bratman SV, Ohashi PS, Pugh TJ, Siu LL.   +21 more
europepmc   +1 more source