Results 21 to 30 of about 222 (121)

Methodology for Biological Sample Collection, Processing, and Storage in the Newcastle 1000 Pregnancy Cohort: Protocol for a Longitudinal, Prospective Population-Based Study in Australia [PDF]

JMIR Research Protocols
BackgroundResearch in the developmental origins of health and disease provides compelling evidence that adverse events during the first 1000 days of life from conception can impact life course health.
Joshua J Fisher, Tegan Grace, Nathan A Castles, Elizabeth A Jones, Sarah J Delforce, Alexandra E Peters, Gabrielle K Crombie, Emily C Hoedt, Kirby E Warren, Richard GS Kahl, Jonathan J Hirst, Kirsty G Pringle, Craig E Pennell   +12 more
doaj   +2 more sources

Quantitative fragmentomics allow affinity mapping of interactomes [PDF]

Nature Communications, 2021
Abstract Human protein networks have been widely explored but most binding affinities remain unknown, hindering quantitative interactome-function studies. Yet interactomes rely on minimal interacting fragments displaying quantifiable affinities.
Gogl, Gergo, Zambo, Boglarka, Kostmann, Camille, Cousido-Siah, Alexandra, Morlet, Bastien, Durbesson, Fabien, Negroni, Luc, Eberling, Pascal, Jané, Pau, Nominé, Yves, Zeke, Andras, Østergaard, Søren, Monsellier, Élodie, Vincentelli, Renaud, Travé, Gilles   +14 more
openaire   +4 more sources

Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection [PDF]

Cancer Discovery
Peter Bach, Joseph Catallini, Kwok Kin Wong   +2 more
exaly   +2 more sources

Predicting disease recurrence in limited disease small cell lung cancer using cell-free DNA-based mutation and fragmentome analyses [PDF]

Translational Lung Cancer Research
Park S, Kang JK, Lee N, Lee SH, Kim HP, Kim SY, Kim TY, Kim H, Jung HA, Sun JM, Ahn JS, Ahn MJ, Park K.   +12 more
exaly   +2 more sources

Multimodal analysis of cell-free DNA whole-methylome sequencing for cancer detection and localization

Nature Communications, 2023
Multimodal epigenetic characterization of cell-free DNA (cfDNA) could improve the performance of blood-based early cancer detection. However, integrative profiling of cfDNA methylome and fragmentome has been technologically challenging. Here, we adapt an
Fenglong Bie, Zhijie Wang, Yulong Li, Wei Guo, Yuanyuan Hong, Tiancheng Han, Fang Lv, Shunli Yang, Suxing Li, Xi Li, Peiyao Nie, Shun Xu, Ruochuan Zang, Moyan Zhang, Peng Song, Feiyue Feng, Jianchun Duan, Guangyu Bai, Yuan Li, Qilin Huai, Bolun Zhou, Yu S. Huang, Weizhi Chen, Fengwei Tan, Shugeng Gao   +24 more
doaj   +1 more source

Cell-free epigenomes enhanced fragmentomics-based model for early detection of lung cancer. [PDF]

Clin Transl Med
Lung cancer‐related changes in fragmentomic features were unevenly distributed across the genome, showing significant enrichment in epigenetically regulated regions of specific genes. The cfDNA fragmentomics‐based model demonstrated superior detection capability, especially for early‐stage lung cancer.
Wang Y, Guo Q, Huang Z, Song L, Zhao F, Gu T, Feng Z, Wang H, Li B, Wang D, Zhou B, Guo C, Xu Y, Song Y, Zheng Z, Bing Z, Li H, Yu X, Fung KL, Xu H, Shi J, Chen M, Hong S, Jin H, Tong S, Zhu S, Zhu C, Song J, Liu J, Li S, Li H, Sun X, Liang N.   +32 more
europepmc   +2 more sources

Identification of ᴅ-amino acid-containing peptides in human serum. [PDF]

PLoS ONE, 2017
Biologically uncommon d-aspartate (d-Asp) residues have been shown to accumulate in proteins associated with age-related human disorders, such as cataract and Alzheimer disease.
Seongmin Ha, Ingu Kim, Takumi Takata, Tadatoshi Kinouchi, Masaharu Isoyama, Minoru Suzuki, Noriko Fujii   +6 more
doaj   +1 more source

Cell-Free DNA Fragmentomics in Liquid Biopsy

Diagnostics, 2022
Cell-free DNA (cfDNA) in bodily fluids has rapidly transformed the development of noninvasive prenatal testing, cancer liquid biopsy, and transplantation monitoring. Plasma cfDNA consists of a mixture of molecules originating from various bodily tissues.
Spencer C. Ding, Y.M. Dennis Lo
openaire   +3 more sources

Emerging frontiers of cell-free DNA fragmentomics

Extracellular Vesicles and Circulating Nucleic Acids, 2022
Analysis of cell-free DNA (cfDNA) in the blood has shown promise for monitoring a variety of biological processes. Plasma cfDNA is a mixture comprising DNA molecules released from various bodily tissues, mediated by characteristic DNA fragmentations occurring during cell death.
Hu, Xi, Ding, Spencer C., Jiang, Peiyong
openaire   +2 more sources

Epigenetic analysis of cell-free DNA by fragmentomic profiling

Proceedings of the National Academy of Sciences, 2022
Cell-free DNA (cfDNA) fragmentation patterns contain important molecular information linked to tissues of origin. We explored the possibility of using fragmentation patterns to predict cytosine-phosphate-guanine (CpG) methylation of cfDNA, obviating the use of bisulfite treatment and associated risks of DNA degradation.
Qing Zhou, Guannan Kang, Peiyong Jiang, Rong Qiao, W. K. Jacky Lam, Stephanie C. Y. Yu, Mary-Jane L. Ma, Lu Ji, Suk Hang Cheng, Wanxia Gai, Wenlei Peng, Huimin Shang, Rebecca W. Y. Chan, Stephen L. Chan, Grace L. H. Wong, Linda T. Hiraki, Stefano Volpi, Vincent W. S. Wong, John Wong, Rossa W. K. Chiu, K. C. Allen Chan, Y. M. Dennis Lo   +21 more
openaire   +2 more sources