Results 121 to 130 of about 291 (138)
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Fragmentomics of proteins and natural oligopeptides
Biophysics, 2008The term fragmentomics is grounded and defined. Theoretical structure-function analysis of all possible fragments of a protein molecule was performed under the concept of fragmentomics to determine the regions that could be potential sources of regulatory oligopeptides.
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Quantitative Fragmentome Mapping Reveals Novel, Domain-specific Partners for the Modular Protein RepoMan (Recruits PP1 Onto Mitotic Chromatin at Anaphase) [PDF]
Molecular and Cellular Proteomics, 2013 RepoMan is a protein phosphatase 1 (PP1) regulatory subunit that targets the phosphatase to key substrates throughout the cell cycle. Most work to date has focused on the mitotic roles of RepoMan/PP1, although equally important interphase role(s) have ...
Delphine Chamousset +2 more
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Multidimensional Fragmentomics Enables Early and Accurate Detection of Colorectal Cancer
Cancer ResearchAbstract Colorectal cancer is frequently diagnosed in advanced stages, highlighting the need for developing approaches for early detection. Liquid biopsy using cell-free DNA (cfDNA) fragmentomics is a promising approach, but the clinical application is hindered by complexity and cost.
Yuepeng Cao +20 more
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cfDNA fragmentomics for preeclampsia prediction
To investigate whether cfDNA fragmentomic features have the potential to predict early-onset or late-onset PE, we performed WGS of plasma cfDNA (>10X final read depth) from pregnant women with PE (n=109 for early-onset PE, n=333 for late-onset PE) and sampling-gestation-matched healthy controls (n=476).openaire +1 more source
Integration of cfDNA fragmentomics for early biliary tract cancer detection.
Journal of Clinical Oncology4131 Background: Biliary Tract Cancer (BTC) is a highly aggressive malignancy with poor survival outcomes, primarily due to the lack of effective early detection methods and late-stage diagnoses.
Jiwen Wang +19 more
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Cell-free DNA fragmentomics and methylomics for thymic epithelial tumors.
Journal of Clinical Oncology8118 Background: Development of circulating cell-free (cf) DNA assays for cancer detection and monitoring is an area of active research. Limited data are available on the utility of cfDNA for thymic epithelial tumors (TETs).
Michael Daniels +12 more
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Prospective Evaluation of cfDNA Fragmentomes for Lung Cancer Detection
C99. ADVANCES IN BIOMARKERS ACROSS THE LUNG CANCER CONTINUUM, 2023P.J. Mazzone +13 more
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Plasma cell-free DNA fragmentomic bioinformatics development
Cell-free DNA (cfDNA) liquid biopsy technology is widely applied in non-invasive prenatal testing (NIPT). Traditional NIPT approaches that only utilize single genetic markers frequently yield inaccurate and unstable testing results, particularly in clinical samples with lower fetal fetal fraction, which limits diagnostic reliability.openaire +1 more source
METHODS AND COMPOSITIONS FOR DETECTING CANCER USING FRAGMENTOMICS
2022KRUGLYAK KRISTINA +2 more
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