Results 101 to 110 of about 222 (121)

Multidimensional Fragmentomics Enables Early and Accurate Detection of Colorectal Cancer

Cancer Research
Abstract Colorectal cancer is frequently diagnosed in advanced stages, highlighting the need for developing approaches for early detection. Liquid biopsy using cell-free DNA (cfDNA) fragmentomics is a promising approach, but the clinical application is hindered by complexity and cost.
Yuepeng Cao, Nannan Wang, Xuxiaochen Wu, Wanxiangfu Tang, Hua Bao, Chengshuai Si, Peng Shao, Dongzheng Li, Xin Zhou, Dongqin Zhu, Shanshan Yang, Fufeng Wang, Guoqing Su, Ke Wang, Qifan Wang, Yao Zhang, Qiangcheng Wang, Dongsheng Yu, Qian Jiang, Jun Bao, Liu Yang   +20 more
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cfDNA fragmentomics for preeclampsia prediction

To investigate whether cfDNA fragmentomic features have the potential to predict early-onset or late-onset PE, we performed WGS of plasma cfDNA (>10X final read depth) from pregnant women with PE (n=109 for early-onset PE, n=333 for late-onset PE) and sampling-gestation-matched healthy controls (n=476).
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Integration of cfDNA fragmentomics for early biliary tract cancer detection.

Journal of Clinical Oncology
4131 Background: Biliary Tract Cancer (BTC) is a highly aggressive malignancy with poor survival outcomes, primarily due to the lack of effective early detection methods and late-stage diagnoses.
Jiwen Wang, Xiaojian Ni, Yuxuan Zheng, Qingxin Xie, Hua Bao, Kun Fan, Dongqin Zhu, Hairong Bao, Ruowei Yang, Chunyan Wang, Bohao Zheng, Shuang Chang, Xiuxiu Xu, Haimeng Tang, Xiaoling Ni, Tao Suo, Xue Wu, Sheng Shen, Han Liu, Houbao Liu   +19 more
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Cell-free DNA fragmentomics and methylomics for thymic epithelial tumors.

Journal of Clinical Oncology
8118 Background: Development of circulating cell-free (cf) DNA assays for cancer detection and monitoring is an area of active research. Limited data are available on the utility of cfDNA for thymic epithelial tumors (TETs).
Michael Daniels, Elizabeth R. Francis, Ling Su, Xiaolin Wu, Elsa Bahiru, Shannon Swift, Christine Feierabend, Susan Sansone, Laercio Lopes DaSilva, Eva Szabo, Chen Zhao, Meredith Jo McAdams, Arun Rajan   +12 more
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Abstract 3505: Classification of cancer subtypes by cfDNA fragmentomics analysis

Cancer Research
Abstract Introduction Fragmentation patterns of cell-free DNA (cfDNA) from whole genome sequencing offer insights into nucleosome occupancy, providing a tool to infer epigenomic and transcriptomic information. The nucleosome complex, the primary protector of cfDNA, is reflected in the size distribution of cfDNA fragments, with a mode ...
Lisha Zhu, Chao Dai, Shuang Gan, Shidong Jia, Pan Du   +4 more
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Prospective Evaluation of cfDNA Fragmentomes for Lung Cancer Detection

C99. ADVANCES IN BIOMARKERS ACROSS THE LUNG CANCER CONTINUUM, 2023
P.J. Mazzone, K.-K. Wong, J.J. Tsay, A. Vachani, A. Ryan, J. Carey, D. Jakubowski, K. Lumbard, J. Catallini, T. Maddala, P.B. Bach, R. Scharpf, N. Dracopoli, V. Velculescu   +13 more
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A method for early diagnosis of lung cancer from tumor originated DNA fragments using plasma cfDNA methylome and fragmentome profiles

Molecular and Cellular Probes, 2022
Hyun Ju Cho
exaly  

METHODS AND COMPOSITIONS FOR DETECTING CANCER USING FRAGMENTOMICS

2022
KRUGLYAK KRISTINA, MARASS FRANCESCO, TSUI WAI YI   +2 more
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Quantitative Fragmentome Mapping Reveals Novel, Domain-specific Partners for the Modular Protein RepoMan (Recruits PP1 Onto Mitotic Chromatin at Anaphase)

Molecular and Cellular Proteomics, 2013
Delphine Chamousset, Isha Nasa, Laura Trinkle-Mulcahy   +2 more
exaly  

Sa1916 INTEGRATING FRAGMENTOMICS AND PROTEOMICS FOR EARLY DETECTION OF CHOLANGIOCARCINOMA

Gastroenterology
Vishruth Girish, Matthew A. Cooley, Caitlin J. VanLith, Adrianna Bartolomucci, Akshaya Annapragada, Daniel C. Bruhm, Sarah Short, Julia Velculescu, Sofia Velculescu, Shashikant Koul, Jillian Phallen, Lewis R. Roberts, Victor Velculescu, Robert B. Scharpf, Zachariah Foda   +14 more
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