Results 31 to 40 of about 303 (142)
Fragmentomic cfDNA Patterns in Noninvasive Prenatal Testing and Beyond
Journal of Biomedicine and Translational Research, 2021 The release of fetoplacental cell-free DNA (cfDNA) into the maternal bloodstream opened up new avenues towards noninvasive prenatal testing (NIPT) for aneuploidies, hereditary DNA mutations and other pregnancy-related developmental disorders. Increasingly, cfDNA catches interest for its noninvasive screening value in other areas as well, including ...
Kavish Kohabir +2 more
openaire +4 more sources
, 2022 HemaSphere, Volume 6, Issue S3, Page 126-127, June 2022.
M. C. Pirosa +41 more
wiley +1 more source
Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection. [PDF]
Nat Rev CancerGenomic analyses of cell-free DNA (cfDNA) in plasma are enabling noninvasive blood-based biomarker approaches to cancer detection and disease monitoring. Current approaches for identification of circulating tumour DNA typically use targeted tumour-specific mutations or methylation analyses.
Bruhm DC +5 more
europepmc +4 more sources
Detection and characterization of lung cancer using cell-free DNA fragmentomes [PDF]
Nature Communications, 2021 AbstractNon-invasive approaches for cell-free DNA (cfDNA) assessment provide an opportunity for cancer detection and intervention. Here, we use a machine learning model for detecting tumor-derived cfDNA through genome-wide analyses of cfDNA fragmentation in a prospective study of 365 individuals at risk for lung cancer. We validate the cancer detection
Dimitrios Mathios +37 more
openaire +6 more sources
Fragmentomics of natural peptide structures
Biochemistry (Moscow), 2009 Natural fragmentation of peptide and other chemical structures is well known. They are a significant object of biochemical investigations. In this connection, the bases and determination are given for the notion of the "fragmentome" as a set of all fragments of a single substance, as well as for global fragmentome of all chemical components of living ...
openaire +4 more sources
AGE-ASSOCIATED VARIABILITY OF CIRCULATING FREE DNA CHARACTERISTICS: GENOME-WIDE ANALYSIS
Journal of Bioinformatics and GenomicsThe fragments of circulating free DNA (cfDNA) found in plasma are formed due to the genomic DNA degradation during cellular death. The present study is the first research of age-associated variability of cfDNA characteristics performed on the group of ...
Meshkov I.O. +13 more
doaj +1 more source
Fragmentomics features of ovarian cancer
International Journal of CancerAbstractOvarian cancer (OC) is a major cause of cancer mortality in women worldwide. Due to the occult onset of OC, its nonspecific clinical symptoms in the early phase, and a lack of effective early diagnostic tools, most OC patients are diagnosed at an advanced stage.
Xiaopei Chao +11 more
openaire +2 more sources
Fragmentomics features of cell free DNA in eating disorders. [PDF]
Transl PsychiatryBurova A +8 more
europepmc +2 more sources
Cancer treatment monitoring using cell-free DNA fragmentomes. [PDF]
Nat CommunAbstractCirculating cell-free DNA (cfDNA) assays for monitoring individuals with cancer typically rely on prior identification of tumor-specific mutations. Here, we develop a tumor-independent and mutation-independent approach (DELFI-tumor fraction, DELFI-TF) using low-coverage whole genome sequencing to determine the cfDNA tumor fraction and validate ...
van 't Erve I +21 more
europepmc +4 more sources
International Journal of Cancer, Volume 158, Issue 10, Page 2771-2783, 15 May 2026.What's New? Circulating nuclear DNA (cir‐nDNA)‐based assessment of minimal residual disease (MRD) offers powerful post‐surgery prognostic insight for stage III colon cancer (CC). Sparse knowledge of post‐surgical variations and origins in cir‐nDNA, however, has limited its clinical application.
Andrei Kudriavtsev +17 more
wiley +1 more source