Results 121 to 130 of about 261 (136)

Longitudinal Noninvasive Surveillance & Fragmentomic Characterization of Follicular Lymphoma

Blood, 2023
Introduction While cell-free DNA (cfDNA) plays an increasingly defined role in aggressive lymphomas, its characteristics in indolent lymphomas are less established. Many follicular lymphoma (FL) patients experience durable remissions and late relapses ( Fig A).
Schroers-Martin, Joseph G., Mutter, Jurik, Rossi, Cédric, Liu, Chih Long, Shahrokh Esfahani, Mohammad, Sugio, Takeshi, Tessoulin, Benoit, Scherer, Florian Paul, Soo, Joanne, Alig, Stefan, Kurtz, David M., Olsen, Mari, Diehn, Maximilian, Alizadeh, Ash A.   +13 more
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Multidimensional Fragmentomics Enables Early and Accurate Detection of Colorectal Cancer

Cancer Research
Abstract Colorectal cancer is frequently diagnosed in advanced stages, highlighting the need for developing approaches for early detection. Liquid biopsy using cell-free DNA (cfDNA) fragmentomics is a promising approach, but the clinical application is hindered by complexity and cost.
Yuepeng Cao, Nannan Wang, Xuxiaochen Wu, Wanxiangfu Tang, Hua Bao, Chengshuai Si, Peng Shao, Dongzheng Li, Xin Zhou, Dongqin Zhu, Shanshan Yang, Fufeng Wang, Guoqing Su, Ke Wang, Qifan Wang, Yao Zhang, Qiangcheng Wang, Dongsheng Yu, Qian Jiang, Jun Bao, Liu Yang   +20 more
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Abstract 1125: Characterizing the cfDNA fragmentome in patients with hepatocellular carcinoma

Cancer Research
Abstract Hepatocellular carcinoma (HCC) is the third leading cause of cancer death globally and is one of the most rapidly increasing causes of cancer mortality in North America and Europe due to metabolic and emerging risk factors. Here, we show that cell-free DNA (cfDNA) fragmentation profiles reflected underlying disease biology ...
Jillian Phallen, Robert B Scharpf
exaly   +2 more sources

cfDNA fragmentomics for preeclampsia prediction

To investigate whether cfDNA fragmentomic features have the potential to predict early-onset or late-onset PE, we performed WGS of plasma cfDNA (>10X final read depth) from pregnant women with PE (n=109 for early-onset PE, n=333 for late-onset PE) and sampling-gestation-matched healthy controls (n=476).
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Abstract 3505: Classification of cancer subtypes by cfDNA fragmentomics analysis

Cancer Research
Abstract Introduction Fragmentation patterns of cell-free DNA (cfDNA) from whole genome sequencing offer insights into nucleosome occupancy, providing a tool to infer epigenomic and transcriptomic information. The nucleosome complex, the primary protector of cfDNA, is reflected in the size distribution of cfDNA fragments, with a mode ...
Lisha Zhu, Chao Dai, Shuang Gan, Shidong Jia, Pan Du   +4 more
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Integration of cfDNA fragmentomics for early biliary tract cancer detection.

Journal of Clinical Oncology
4131 Background: Biliary Tract Cancer (BTC) is a highly aggressive malignancy with poor survival outcomes, primarily due to the lack of effective early detection methods and late-stage diagnoses.
Jiwen Wang, Xiaojian Ni, Yuxuan Zheng, Qingxin Xie, Hua Bao, Kun Fan, Dongqin Zhu, Hairong Bao, Ruowei Yang, Chunyan Wang, Bohao Zheng, Shuang Chang, Xiuxiu Xu, Haimeng Tang, Xiaoling Ni, Tao Suo, Xue Wu, Sheng Shen, Han Liu, Houbao Liu   +19 more
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Prospective Evaluation of cfDNA Fragmentomes for Lung Cancer Detection

C99. ADVANCES IN BIOMARKERS ACROSS THE LUNG CANCER CONTINUUM, 2023
P.J. Mazzone, K.-K. Wong, J.J. Tsay, A. Vachani, A. Ryan, J. Carey, D. Jakubowski, K. Lumbard, J. Catallini, T. Maddala, P.B. Bach, R. Scharpf, N. Dracopoli, V. Velculescu   +13 more
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Abstract 3772: Leveraging the cfDNA fragmentome to predict immunotherapy response

Cancer Research
Abstract Background: Assessing immunotherapy response presents unique challenges, driven by the heterogeneity of clinical responses that are inadequately captured by conventional imaging. Early changes in circulating tumor DNA (ctDNA), captured by mutation-based next generation sequencing (NGS), have ...
Noushin Niknafs, Lavanya Sivapalan, Bahar Alipanahi, Daniel Rabizadeh, Mimi Najjar, Zachary L. Skidmore, Gavin Pereira, Caitlin Schonewolf, Bryan Chesnick, Peter Bach, Nicholas C. Dracopoli, Robert Scharpf, Joseph Murray, Victor Velculescu, Valsamo (Elsa) K. Anagnostou   +14 more
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Impact of Clinical Variables on cfDNA Fragmentomic Signatures and Their Potential as Confounders in Cancer Detection

Clinical Chemistry
Abstract Background Circulating cell-free DNA (cfDNA) fragmentomic features, such as fragment size and end motifs, have emerged as promising noninvasive biomarkers for cancer detection. However, the influence of nonmalignant clinical factors on these features remains unclear, potentially ...
Tae-Rim Lee, Eun Hye Cho, Jin Mo Ahn, Junnam Lee, Chang-Seok Ki, Byeong-Ho Jeong, Min-Jung Kwon, Eun-Hae Cho   +7 more
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Abstract 5884: Cancer subtype classification by cfDNA fragmentomics analysis

Cancer Research
Introduction: Nucleosome occupancy patterns at transcription factor binding sites (TFBS) exhibit differences between circulating tumor DNA (ctDNA) in cancer patients and normal plasma controls, as well as among different tumor subtypes.
Lisha Zhu, Chao Dai, Shuang Gan, Shidong Jia, Pan Du   +4 more
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