Results 61 to 70 of about 222 (118)

Cell-Free DNA Fragmentomics: The New “Omics” on the Block [PDF]

open access: yesClinical Chemistry, 2020
Rossa W K Chiu   +4 more
openaire   +1 more source

Cell-free DNA fragmentomics for preeclampsia risk assessment

open access: yesNature Communications
Abstract Preeclampsia (PE) is a pregnancy-specific hypertensive disorder that could lead to serious maternal and fetal complications, yet early identification of women at risk remains challenging because reliable biomarkers are limited.
Wenqiu Xu   +39 more
openaire   +1 more source

Poster Sessions

open access: yes
HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Seminal plasma cfDNA fragmentomics landscape delineates male infertility subtypes

open access: yesClinical Epigenetics
Abstract Background While cell-free DNA (cfDNA) fragmentomics has transformed liquid biopsy applications in prenatal screening and oncology, its potential in male reproductive health remains uncharted. Methods Through integrated whole-genome sequencing and jagged end sequencing (Jag-Seq) coupled with non-CpG methylation analysis, we ...
Wu, Xiaoyu   +4 more
openaire   +2 more sources

Abstracts

open access: yes
Cancer Science, Volume 116, Issue S1, Page 1-1975, January 2025.
wiley   +1 more source

Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA

open access: yesAdvanced Science
ABSTRACT Cell‐free DNA (cfDNA) in plasma consists of short DNA fragments resulting from a non‐random fragmentation process, with distinct fragmentomic characteristics that are related with their cellular origins. Here, we report that somatic variant signatures in cfDNA markedly differ between non‐cancerous controls and cancer patients,
Zhenyu Zhang   +12 more
openaire   +2 more sources

Leveraging cfDNA fragmentomic features for the early detection of colorectal cancer

open access: yesFrontiers in Immunology
Background Early detection of colorectal cancer (CRC) is crucial for improving patient outcomes. Cell-free DNA (cfDNA) analysis has emerged as a promising non-invasive approach for cancer detection. This study aims to develop a machine learning algorithm leveraging cfDNA fragmentomic features to accurately ...
Shan, Lina   +11 more
openaire   +2 more sources

Sinteza nove piridinijeve soli s triazolilidenskim fragmentom

open access: yes, 2020
This thesis describes the synthesis of a novel pyridinium salt bearing triazolylidene fragment bounded to pyridine nitrogen atom, which has not yet been described in the literature. The synthesized salt represents a potential bidentate dicarbene NHC ligand, useful for the formation of transition metal NHC complexes.
openaire   +1 more source

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