Results 61 to 70 of about 222 (118)
Cell-Free DNA Fragmentomics: The New “Omics” on the Block [PDF]
Rossa W K Chiu +4 more
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Cell-free DNA fragmentomics for preeclampsia risk assessment
Abstract Preeclampsia (PE) is a pregnancy-specific hypertensive disorder that could lead to serious maternal and fetal complications, yet early identification of women at risk remains challenging because reliable biomarkers are limited.
Wenqiu Xu +39 more
openaire +1 more source
Seminal plasma cfDNA fragmentomics landscape delineates male infertility subtypes
Abstract Background While cell-free DNA (cfDNA) fragmentomics has transformed liquid biopsy applications in prenatal screening and oncology, its potential in male reproductive health remains uncharted. Methods Through integrated whole-genome sequencing and jagged end sequencing (Jag-Seq) coupled with non-CpG methylation analysis, we ...
Wu, Xiaoyu +4 more
openaire +2 more sources
Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA
ABSTRACT Cell‐free DNA (cfDNA) in plasma consists of short DNA fragments resulting from a non‐random fragmentation process, with distinct fragmentomic characteristics that are related with their cellular origins. Here, we report that somatic variant signatures in cfDNA markedly differ between non‐cancerous controls and cancer patients,
Zhenyu Zhang +12 more
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Leveraging cfDNA fragmentomic features for the early detection of colorectal cancer
Background Early detection of colorectal cancer (CRC) is crucial for improving patient outcomes. Cell-free DNA (cfDNA) analysis has emerged as a promising non-invasive approach for cancer detection. This study aims to develop a machine learning algorithm leveraging cfDNA fragmentomic features to accurately ...
Shan, Lina +11 more
openaire +2 more sources
Commentary: Techniques for removal of posteriorly dislocated lens fragment. [PDF]
Babu N, Kohli P.
europepmc +1 more source
Sinteza nove piridinijeve soli s triazolilidenskim fragmentom
This thesis describes the synthesis of a novel pyridinium salt bearing triazolylidene fragment bounded to pyridine nitrogen atom, which has not yet been described in the literature. The synthesized salt represents a potential bidentate dicarbene NHC ligand, useful for the formation of transition metal NHC complexes.
openaire +1 more source

