Results 71 to 80 of about 164 (114)

Cell-Free DNA Fragmentome Dynamics as a Biomarker for Immune-Checkpoint Inhibition in Advanced Carcinoma

International audienceEarly prediction of resistance to immunotherapy is a major challenge in oncology. The ongoing SChISM (Size Cell-fre DNA (cfDNA) Immunotherapies Signature Monitoring) clinical study proposes an innovative approach based on patented ...
Boutonnet, Audrey, Fina, Frederic, Della-Negra, Lucie, Nguyen Phuong, Linh, Tomasini, Pascale, Greillier, Laurent, Garcia, Jean-Charles, Salas, Sébastien, Ginot, Frédéric, Zakrajsek, Romain, Deville, Jean-Laurent, Benzekry, Sébastien   +11 more
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Holistic Integration of Deep Learning Models for Mass Spectrometry-Based Peptide Identification

Tandem mass spectrometry (MS/MS) coupled with liquid chromatography and/or ion mobility separation is an essential experimental technique for high-throughput discovery of the proteome, or the collection of proteins in a biological system.
Yang, Kevin
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-fragmentome

, 2015

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Sinteza nove piridinijeve soli s triazolilidenskim fragmentom

, 2020
This thesis describes the synthesis of a novel pyridinium salt bearing triazolylidene fragment bounded to pyridine nitrogen atom, which has not yet been described in the literature. The synthesized salt represents a potential bidentate dicarbene NHC ligand, useful for the formation of transition metal NHC complexes.
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Combining cell-free DNA fragmentomes and total tumour volume improves prognostication and tumour response evaluation in patients with colorectal cancer liver metastases

Background: Treatment decisions in patients with unresectable colorectal liver metastases (CRLM) are largely guided by radiological response to induction systemic therapy.
Stoker, Jaap, Verpalen, Inez, van 't Erve, Iris, van den Bergh, Janneke, Kok, Niels F.M., Moos, Shira, Kemna, Ruby, van Waesberghe, Jan Hein, Bond, Marinde J.G., Lumbard, Keith, Huiskens, Joost, van Steijn, Denise, Alipanahi, Bahar, Huitink, Iris, Zeeuw, J. Michiel, Ali, Mahsoem, Giovannetti, Elisa, Dracopoli, Nicholas C., Wesdorp, Nina J., Rinaldi, Lorenzo, Meiqari, Lana, Epi Kanker Team B, Fijneman, Remond J.A., Kazemier, Geert, Punt, Cornelis J.A., Nota, Irena, Leal, Alessandro, Skidmore, Zachary L., Velculescu, Victor E., van den Broek, Daan, Scharpf, Robert B., Meijer, Gerrit A., Swijnenburg, Rutger Jan, Crnovrsanin, Nerma, Cancer   +34 more
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Mechanistic Modeling of Joint Circulating Cell-free DNA Concentration—Tumor Size Kinetics under Immune-Checkpoint Inhibitors in Advanced Cancer

International audienceObjectivesIn cancer patients, the plasmatic concentration of global cfDNA — shed by both tumor and wild-type (especially immune) cells — rises and fluctuates with tumor size, number of metastases, and treatment[1].
Boutonnet, Audrey, Della-Negra, Lucie, Nguyen Phuong, Linh, Greillier, Laurent, Garcia, Jean-Charles, Benzekry, Sébastien, Fina, Frederic, Tomasini, Pascale, Gaudy-Marqueste, Caroline, Salas, Sébastien, Ginot, Frédéric, Zakrajsek, Romain, Deville, Jean-Laurent   +12 more
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Moving Forward Liquid Biopsy in Early Liver Cancer Detection

, 2023
Christian Rolfo, Alessandro Russo
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Characterization of global cfDNA fragmentomics in Melanoma Patients

EJC Skin Cancer
J.L. Villanueva-Cañas, D. Rizo-Potau, A. Fornies, M. Aguilar, C. Sanchez-Cardenas, C. Carrera, S. Puig, J. Malvehy, J.A. Puig-Butille   +8 more
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Detection and characterization of hepatocellular carcinoma using cfDNA fragmentomes

Cell Press Blue
Hope Orjuela, Carter Norton, Shashikant Koul, Daniel C. Bruhm, Akshaya V. Annapragada, Jason Zavras, Sarah Short, Keerti Boyapati, Adrianna Bartolomucci, Vilmos Adleff, Nicholas A. Vulpescu, Kaui Patricio Lebarbenchon, Jacob Carey, Carter Portwood, Andrei Sorop, Razvan Iacob, Speranta Iacob, Liana Gheorghe, Simona Dima, Manuel Ramírez-Zea, Katherine A. McGlynn, Jillian Phallen, Robert B. Scharpf, John Groopman, Victor E. Velculescu, Zachariah H. Foda   +25 more
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Peptide MS/MS-fragmentome

, 2015

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