Results 11 to 20 of about 222 (122)

A method of comprehensive sequencing analysis of the small RNA fragmentome (RiboMarker) [PDF]

Rna
Circulating cell-free nucleic acids (cfDNA and cfRNA) found in blood and other biofluids are promising biomarkers for cancer. However, current methods exploiting tumor-derived cfDNA (ctDNA) are not sensitive enough in detecting minimal residual disease and early stages of cancer when it is more treatable.
Aidan C Manning, Sérgio Barberán-Soler, Sergei A Kazakov   +2 more
exaly   +4 more sources

Circulating DNA fragmentomics and cancer screening. [PDF]

Cell Genom, 2023
The high fragmentation of nuclear circulating DNA (cirDNA) relies on chromatin organization and protection or packaging within mononucleosomes, the smallest and the most stabilized structure in the bloodstream. The detection of differing size patterns, termed fragmentomics, exploits information about the nucleosomal packing of DNA.
Thierry AR.
europepmc   +5 more sources

Quantitative fragmentomics allow affinity mapping of interactomes [PDF]

Nature Communications, 2021
Abstract Human protein networks have been widely explored but most binding affinities remain unknown, hindering quantitative interactome-function studies. Yet interactomes rely on minimal interacting fragments displaying quantifiable affinities.
Gogl, Gergo, Zambo, Boglarka, Kostmann, Camille, Cousido-Siah, Alexandra, Morlet, Bastien, Durbesson, Fabien, Negroni, Luc, Eberling, Pascal, Jané, Pau, Nominé, Yves, Zeke, Andras, Østergaard, Søren, Monsellier, Élodie, Vincentelli, Renaud, Travé, Gilles   +14 more
openaire   +4 more sources

Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection [PDF]

Cancer Discovery
Peter Bach, Joseph Catallini, Kwok Kin Wong   +2 more
exaly   +2 more sources

Predicting disease recurrence in limited disease small cell lung cancer using cell-free DNA-based mutation and fragmentome analyses [PDF]

Translational Lung Cancer Research
Park S, Kang JK, Lee N, Lee SH, Kim HP, Kim SY, Kim TY, Kim H, Jung HA, Sun JM, Ahn JS, Ahn MJ, Park K.   +12 more
exaly   +2 more sources

Detecting Liver Cancer Using Cell-Free DNA Fragmentomes. [PDF]

Cancer Discov, 2023
Abstract Liver cancer is a major cause of cancer mortality worldwide. Screening individuals at high risk, including those with cirrhosis and viral hepatitis, provides an avenue for improved survival, but current screening methods are inadequate.
Foda ZH, Annapragada AV, Boyapati K, Bruhm DC, Vulpescu NA, Medina JE, Mathios D, Cristiano S, Niknafs N, Luu HT, Goggins MG, Anders RA, Sun J, Sun J, Meta SH, Thomas DL, Kirk GD, Adleff V, Phallen J, Scharpf RB, Kim AK, Velculescu VE.   +21 more
europepmc   +3 more sources

Multimodal analysis of cell-free DNA whole-methylome sequencing for cancer detection and localization

Nature Communications, 2023
Multimodal epigenetic characterization of cell-free DNA (cfDNA) could improve the performance of blood-based early cancer detection. However, integrative profiling of cfDNA methylome and fragmentome has been technologically challenging. Here, we adapt an
Fenglong Bie, Zhijie Wang, Yulong Li, Wei Guo, Yuanyuan Hong, Tiancheng Han, Fang Lv, Shunli Yang, Suxing Li, Xi Li, Peiyao Nie, Shun Xu, Ruochuan Zang, Moyan Zhang, Peng Song, Feiyue Feng, Jianchun Duan, Guangyu Bai, Yuan Li, Qilin Huai, Bolun Zhou, Yu S. Huang, Weizhi Chen, Fengwei Tan, Shugeng Gao   +24 more
doaj   +1 more source

Identification of ᴅ-amino acid-containing peptides in human serum. [PDF]

PLoS ONE, 2017
Biologically uncommon d-aspartate (d-Asp) residues have been shown to accumulate in proteins associated with age-related human disorders, such as cataract and Alzheimer disease.
Seongmin Ha, Ingu Kim, Takumi Takata, Tadatoshi Kinouchi, Masaharu Isoyama, Minoru Suzuki, Noriko Fujii   +6 more
doaj   +1 more source

Cell-Free DNA Fragmentomics in Liquid Biopsy

Diagnostics, 2022
Cell-free DNA (cfDNA) in bodily fluids has rapidly transformed the development of noninvasive prenatal testing, cancer liquid biopsy, and transplantation monitoring. Plasma cfDNA consists of a mixture of molecules originating from various bodily tissues.
Spencer C. Ding, Y.M. Dennis Lo
openaire   +3 more sources

Emerging frontiers of cell-free DNA fragmentomics

Extracellular Vesicles and Circulating Nucleic Acids, 2022
Analysis of cell-free DNA (cfDNA) in the blood has shown promise for monitoring a variety of biological processes. Plasma cfDNA is a mixture comprising DNA molecules released from various bodily tissues, mediated by characteristic DNA fragmentations occurring during cell death.
Hu, Xi, Ding, Spencer C., Jiang, Peiyong
openaire   +2 more sources